PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22516788-9 2012 Blockade of the H(2)R by famotidine enhanced histamine-induced chemotaxis but not rises in [Ca(2+)](i). Histamine 45-54 histamine receptor H2 Homo sapiens 16-21 23677734-7 2013 But recent studies show that histamine antagonists against H3R and regulation of H2R can be more efficient in AD therapy. Histamine 29-38 histamine receptor H2 Homo sapiens 81-84 22516788-12 2012 In conclusion, histamine is only an incomplete eosinophil activator with the H(2)R blunting the small chemotactic response to H(4)R activation. Histamine 15-24 histamine receptor H2 Homo sapiens 77-82 19825989-1 2009 Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). Histamine 0-9 histamine receptor H2 Homo sapiens 56-60 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Histamine 4-13 histamine receptor H2 Homo sapiens 159-162 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Histamine 4-13 histamine receptor H2 Homo sapiens 159-162 22304689-10 2012 These results suggest that histamine down-regulates NKG2D ligands through the activation of an H1R- and H2R-mediated ubiquitin-proteasome pathway and consequently reduces susceptibility to NK cells. Histamine 27-36 histamine receptor H2 Homo sapiens 104-107 20722760-8 2011 When stimulated with lipopolysaccharide in the presence of histamine, slanDC produced substantially lower levels of the pro-inflammatory cytokines tumour necrosis factor-alpha and IL-12, mediated solely via the H(4) R and via the combined action of H(2) R and H(4) R, respectively. Histamine 59-68 histamine receptor H2 Homo sapiens 249-255 21956435-8 2012 IF double-labelling experiments showed a strong correlation of increased histamine expression with expression of H1R and H2R on intestinal enterocytes (histamine/H1R, rho = 0.841, p < 0.0001 and histamine/H2R, rho = 0.806, p < 0.0001). Histamine 73-82 histamine receptor H2 Homo sapiens 121-124 21956435-8 2012 IF double-labelling experiments showed a strong correlation of increased histamine expression with expression of H1R and H2R on intestinal enterocytes (histamine/H1R, rho = 0.841, p < 0.0001 and histamine/H2R, rho = 0.806, p < 0.0001). Histamine 73-82 histamine receptor H2 Homo sapiens 208-211 21956435-8 2012 IF double-labelling experiments showed a strong correlation of increased histamine expression with expression of H1R and H2R on intestinal enterocytes (histamine/H1R, rho = 0.841, p < 0.0001 and histamine/H2R, rho = 0.806, p < 0.0001). Histamine 152-161 histamine receptor H2 Homo sapiens 121-124 20136675-3 2010 In addition, histamine has immunomodulatory functions, some of which are related to the histamine H2 receptor. Histamine 13-22 histamine receptor H2 Homo sapiens 88-109 11898002-8 2002 Stimulation of dendritic cells with histamine resulted in F-actin polymerization and cyclic adenosine monophosphate production through H2R. Histamine 36-45 histamine receptor H2 Homo sapiens 135-138 14744809-7 2004 The suppressive effect of histamine on LT biosynthesis was abrogated by the histamine H(2) receptor antagonists cimetidine, ranitidine, and tiotidine. Histamine 26-35 histamine receptor H2 Homo sapiens 76-99 10837353-3 2000 Histamine induced an increase in c-jun mRNA in human embryonic kidney cells stably transfected with the hH(2)R (maximal effect: 554.6 +/- 86.8% of control). Histamine 0-9 histamine receptor H2 Homo sapiens 104-110 11723228-3 2001 The potencies and efficacies of small H2R agonists in the GTPase assay and the potencies of antagonists at inhibiting histamine-stimulated GTP hydrolysis by hH2R-GsalphaS and gpH2R-GsalphaS were similar. Histamine 118-127 histamine receptor H2 Homo sapiens 157-161 11728449-4 2001 This histamine effect on LOX-1 gene expression, via the histamine H2 receptor-mediated cAMP signal transduction pathway, was reduced after differentiation of the cells into macrophages, even though forskolin and Bt2-cAMP still enhanced the gene expression. Histamine 5-14 histamine receptor H2 Homo sapiens 56-77 11678636-7 2001 Histamine-induced surface expression of P-selectin was blocked by the histamine H2 receptor antagonist cimetidine. Histamine 0-9 histamine receptor H2 Homo sapiens 70-91 8951654-6 1996 Recently, we have shown that histamine binds to the histamine H2 receptor as a monocation in its proximal tautomeric form, and, moreover, we suggested that a proton is donated from the receptor towards the tele-position of the agonist, thereby triggering the biological effect [Nederkoorn et al., J. Mol. Histamine 29-38 histamine receptor H2 Homo sapiens 52-73 10329833-2 1999 Histamine H2 receptor (H2R) stimulation controls histamine release and mediates mucus secretion, suggesting that H2R might play some role in allergic rhinitis. Histamine 49-58 histamine receptor H2 Homo sapiens 0-21 10329833-2 1999 Histamine H2 receptor (H2R) stimulation controls histamine release and mediates mucus secretion, suggesting that H2R might play some role in allergic rhinitis. Histamine 49-58 histamine receptor H2 Homo sapiens 23-26 10329833-2 1999 Histamine H2 receptor (H2R) stimulation controls histamine release and mediates mucus secretion, suggesting that H2R might play some role in allergic rhinitis. Histamine 49-58 histamine receptor H2 Homo sapiens 113-116 8982295-4 1996 The effect of histamine was completely blocked by the histamine H2-receptor (H2R) antagonist ranitidine but not by its chemical control AH20399AA. Histamine 14-23 histamine receptor H2 Homo sapiens 54-75 8951655-10 1996 The earlier suggested three-point interaction of histamine with the histamine H2 receptor can be explored. Histamine 49-58 histamine receptor H2 Homo sapiens 68-89 7915087-4 1994 In THP-1 macrophages, histamine inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-induced H2O2 formation via the activation of H2 receptors. Histamine 22-31 histamine receptor H2 Homo sapiens 132-144 8711434-3 1996 The protective effect of histamine was blocked by the H2-receptor (H2R) antagonist ranitidine but not by AH202399 A, a chemical control to ranitidine devoid of H2R affinity. Histamine 25-34 histamine receptor H2 Homo sapiens 54-70 8616026-4 1996 The effect of histamine was apparently mediated by H2-type histamine receptors (H2R), since the H2R antagonist ranitidine completely blocked the response. Histamine 14-23 histamine receptor H2 Homo sapiens 51-78 8616026-4 1996 The effect of histamine was apparently mediated by H2-type histamine receptors (H2R), since the H2R antagonist ranitidine completely blocked the response. Histamine 14-23 histamine receptor H2 Homo sapiens 80-83 8616026-4 1996 The effect of histamine was apparently mediated by H2-type histamine receptors (H2R), since the H2R antagonist ranitidine completely blocked the response. Histamine 14-23 histamine receptor H2 Homo sapiens 96-99 7696215-1 1994 The historical model for the agonistic binding site on the histamine H2-receptor is based on a postulated activation mechanism: it has been suggested that the histamine monocation binds to the histamine H2-receptor via the formation of three hydrogen bonds. Histamine 59-68 histamine receptor H2 Homo sapiens 193-214 7879707-6 1994 Histamine induced increase in IL-5 production was inhibited by histamine H2-receptor antagonists, but remained unaffected by H1- or H3-receptor antagonists. Histamine 0-9 histamine receptor H2 Homo sapiens 63-84 8800567-18 1996 Histamine may stimulate tumour growth through the histamine H2-receptor, while the dominant effect of 5-HT is 5-HT1-receptor inhibition. Histamine 0-9 histamine receptor H2 Homo sapiens 50-71 1358393-8 1992 The contractile response to histamine was antagonized by the histamine H1-receptor antagonist, clemizole (0.1 microM) but was potentiated by the histamine H2-receptor antagonist, ranitidine (10 microM). Histamine 28-37 histamine receptor H2 Homo sapiens 145-166 8120456-7 1994 The indirect effect of histamine on ADCC of NK cells and the effect of histamine on ADCC of monocytes/neutrophils were completely antagonized by the specific H2 receptor (H2R) blocker ranitidine. Histamine 23-32 histamine receptor H2 Homo sapiens 158-169 8120456-7 1994 The indirect effect of histamine on ADCC of NK cells and the effect of histamine on ADCC of monocytes/neutrophils were completely antagonized by the specific H2 receptor (H2R) blocker ranitidine. Histamine 23-32 histamine receptor H2 Homo sapiens 171-174 8120456-7 1994 The indirect effect of histamine on ADCC of NK cells and the effect of histamine on ADCC of monocytes/neutrophils were completely antagonized by the specific H2 receptor (H2R) blocker ranitidine. Histamine 71-80 histamine receptor H2 Homo sapiens 158-169 8120456-7 1994 The indirect effect of histamine on ADCC of NK cells and the effect of histamine on ADCC of monocytes/neutrophils were completely antagonized by the specific H2 receptor (H2R) blocker ranitidine. Histamine 71-80 histamine receptor H2 Homo sapiens 171-174 8288442-8 1993 The inhibitory effects of histamine on [Ca2+]i accumulation in differentiated cells were partially reversed by histamine H2 receptor antagonist ranitidine, whereas in undifferentiated cells, the effects of histamine on Ca2+ mobilization were not affected by ranitidine. Histamine 26-35 histamine receptor H2 Homo sapiens 111-132 1356984-0 1992 Molecular basis for the interaction of histamine with the histamine H2 receptor. Histamine 39-48 histamine receptor H2 Homo sapiens 58-79 1905105-6 1991 We have extended these studies on HL-60 cells to investigate whether histamine-bovine serum albumin conjugates (HA-BSA) specifically recognize H2R and activate phospholipase C pathways. Histamine 69-78 histamine receptor H2 Homo sapiens 143-146 1356815-5 1992 Furthermore, the cAMP-enhancing effects of isoprenaline, salbutamol and histamine appeared to be mediated via beta 2-adrenoceptors and histamine H2-receptor subtypes respectively. Histamine 72-81 histamine receptor H2 Homo sapiens 135-156 1905105-7 1991 Both histamine (HA) and HA-BSA increased intracellular concentrations of calcium in a H2R specific manner. Histamine 5-14 histamine receptor H2 Homo sapiens 86-89 34769080-6 2021 Histamine increased the cytokine-induced upregulation of CCL18 mRNA expression by stimulating the H2R. Histamine 0-9 histamine receptor H2 Homo sapiens 98-101 1682955-5 1991 In the presence of 100 mumol/l histamine the Ki values (mumol/l) for the histamine H2 receptor antagonists averaged 1.45 (cimetidine), 0.10 (ranitidine), and 0.02 (famotidine). Histamine 31-40 histamine receptor H2 Homo sapiens 73-94 2042038-1 1991 Histamine H2-receptor antagonists inhibit basal and all kinds of stimulated acid secretion with about the same effectiveness, and hence, local release of histamine is thought to be necessary for the stimulation of parietal cells. Histamine 154-163 histamine receptor H2 Homo sapiens 0-21 1693229-4 1990 The development of NKCC in response to histamine was time-dependent with (i) an induction phase, dependent on the presence of accessory monocytes and ongoing histamine H2-receptor activation (half-maximal response required approximately 30 min treatment of large granular lymphocyte (LGL)-enriched lymphocytes and monocytes with histamine), and (ii) an effector phase, independent of the presence of monocytes or histamine receptor activation. Histamine 39-48 histamine receptor H2 Homo sapiens 158-179 35343587-2 2022 Histamine receptor type 2, which is expressed in the nucleus accumbens, couple to Galphas/off proteins which elevate cyclic adenosine monophosphate levels and activate protein kinase A. Whole-cell patch-clamp recordings revealed that H2R activation increased the evoked firing in medium spiny neurons of the nucleus accumbens via protein kinase A-dependent mechanisms. Histamine 0-9 histamine receptor H2 Homo sapiens 234-237 34576210-3 2021 The histamine H2 and H4 receptors (H2R and H4R) are prominent members of Gs- and Gi-coupled GPCRs. Histamine 4-13 histamine receptor H2 Homo sapiens 35-38 34576210-7 2021 Compared to H2R-mGs expressing cells, histamine responses were weaker (pEC50, Emax) for H2R-mGsi and -mGsq. Histamine 38-47 histamine receptor H2 Homo sapiens 88-91 35343587-15 2022 Abstract figure legend Pharmacological activation of histamine receptor type 2 (H2R) elevates the frequency of evoked firing in medium spiny neurons (MSNs) of the nucleus accumbens (NAc).The mechanism underling this effect requires PKA-dependent phosphorylation and downregulation of Kv4.2 channels, the molecular determinant of A-type K+ currents. Histamine 53-62 histamine receptor H2 Homo sapiens 80-83 7214199-10 1980 Part of the chronotropic response to both histamine and 4-MH is due to histamine H2-receptor stimulation. Histamine 42-51 histamine receptor H2 Homo sapiens 71-92 35548336-7 2022 Histamine activates H2R signaling, while famotidine specifically blocks H2R activation. Histamine 0-9 histamine receptor H2 Homo sapiens 20-23 35548336-10 2022 Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine. Histamine 38-47 histamine receptor H2 Homo sapiens 248-251 35548336-10 2022 Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine. Histamine 52-61 histamine receptor H2 Homo sapiens 248-251 2770397-4 1989 By blocking histamine receptors with H1 and H2 antagonists which were used either separately or together before cumulative histamine concentrations, it has been concluded that histamine actions are exerted not exclusively by H1-receptors but also histamine H2-receptor antagonists can significantly decrease the tonicizing effect of histamine. Histamine 12-21 histamine receptor H2 Homo sapiens 247-268 2770397-4 1989 By blocking histamine receptors with H1 and H2 antagonists which were used either separately or together before cumulative histamine concentrations, it has been concluded that histamine actions are exerted not exclusively by H1-receptors but also histamine H2-receptor antagonists can significantly decrease the tonicizing effect of histamine. Histamine 123-132 histamine receptor H2 Homo sapiens 247-268 2770397-4 1989 By blocking histamine receptors with H1 and H2 antagonists which were used either separately or together before cumulative histamine concentrations, it has been concluded that histamine actions are exerted not exclusively by H1-receptors but also histamine H2-receptor antagonists can significantly decrease the tonicizing effect of histamine. Histamine 123-132 histamine receptor H2 Homo sapiens 247-268 2897711-2 1988 The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine. Histamine 14-23 histamine receptor H2 Homo sapiens 130-151 2897711-2 1988 The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine. Histamine 81-90 histamine receptor H2 Homo sapiens 130-151 2897711-2 1988 The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine. Histamine 81-90 histamine receptor H2 Homo sapiens 130-151 2451645-5 1988 The enhanced release of histamine and LTC4 from basophils challenged with allergen was suppressed by Dimaprit, a histamine H2 receptor agonist, at a concentration required to inhibit the release by 50% of 5 X 10(-5) M for histamine and 10(-5) M for LTC4. Histamine 24-33 histamine receptor H2 Homo sapiens 113-134 3722819-6 1986 The histamine-induced enhancement was mimicked by dimaprit, a specific histamine H2-receptor agonist, but not by N-methyldimaprit, a chemical control for H2-receptor agonist activity of dimaprit. Histamine 4-13 histamine receptor H2 Homo sapiens 71-92 2942011-1 1986 Histamine produced a time-dependent (half-life: 20 min at 37 degrees C), temperature-dependent (no effect at 20 degrees C) and homologous desensitization of histamine H2 receptor activity (H2 R) in HGT-1 cells. Histamine 0-9 histamine receptor H2 Homo sapiens 157-193 3706047-7 1986 In addition, they suggest that highly histamine-responsive clones may be useful models to study the gastric histamine H2-receptor and its specific antagonists in the human. Histamine 38-47 histamine receptor H2 Homo sapiens 108-129 6094245-1 1984 Short-term treatment of cultured HGT-1 cells with histamine produced a time-dependent (half-life: 20 min) and homologous desensitization of histamine H2 receptor activity mediating cAMP generation in HGT-1 cells and gastric acid secretion in normal gastric mucosa. Histamine 50-59 histamine receptor H2 Homo sapiens 140-161 6084413-1 1984 Histamine H2-receptor antagonists must be used with caution to define the pharmacology of histamine effects on lymphocyte mitogenesis induced by PHA, because they can enhance and/or suppress in their own right, because these effects are similar to those of histamine itself, because mitogenic doses of PHA can release significant amounts of histamine from supposedly pure mononuclear cell preparations. Histamine 90-99 histamine receptor H2 Homo sapiens 0-21 6131126-2 1983 This process, when applied to histamine, leads to the competitive histamine H2-receptor antagonist prototype 3-amino-5-(2-amino-4-pyridyl)-1,2,4-triazole (7). Histamine 30-39 histamine receptor H2 Homo sapiens 66-87 32719-0 1978 [Histamine and its role in peptic gastric diseases: the discovery of histamine-H2-receptor antagonists]. Histamine 1-10 histamine receptor H2 Homo sapiens 69-90 6159765-1 1980 The fact that histamine H2-receptor antagonists strongly inhibit basal and nocturnal gastric secretion and acid secretion stimulated by histamine, pentagastrin, caffeine, insulin, sham feeding and food indicate that histamine plays a physiological role in gastric acid secretion. Histamine 136-145 histamine receptor H2 Homo sapiens 14-35 6266368-3 1980 The present study is concerned with the effect of histamine on the ability of T lymphocytes for E rosette formation after blockade of the histamine H2 receptor with its inhibitor cimetidine. Histamine 50-59 histamine receptor H2 Homo sapiens 138-159 6266368-4 1980 It has been found that histamine effect is expressed by the histamine H2 receptor, as its blockade with cimetidine leads to the failure of histamine to inhibit rosette formation by T lymphocytes. Histamine 23-32 histamine receptor H2 Homo sapiens 60-81 445880-0 1979 Histamine H2-receptor antagonists inhibit enzymic histamine degradation in human skin. Histamine 50-59 histamine receptor H2 Homo sapiens 0-21 200414-5 1977 This stimulatory effect of histamine was blocked by metiamide, a histamine H2-receptor antagonist, but not by chlorpheniramine, a histamine H1-receptor antagonist. Histamine 27-36 histamine receptor H2 Homo sapiens 65-86 19347-1 1977 Histamine H2-receptor antagonists (Burimamide, Metiamide and Cimetidine as the most recent generation) may drastically inhibit gastric acid secretion stimulated by histamine, pentagastrin, insulin, 2-deoxyglucose or an intragastrically instilled meal, respectively. Histamine 164-173 histamine receptor H2 Homo sapiens 0-21 33548637-6 2021 Most of the compounds presented here exhibited an excellent selectivity profile towards the hH2R, e.g. 157 being at least 3800-fold selective within the histamine receptor family. Histamine 153-162 histamine receptor H2 Homo sapiens 92-96 901705-0 1977 Vascular reactions to histamine and compound 48/80 in human skin: suppression by a histamine H2-receptor blocking agent. Histamine 22-31 histamine receptor H2 Homo sapiens 83-104 10467-1 1976 Histamine H2-receptor antagonists, including burimamide, metiamide and cimetidine, are effective antagonists of histamine-stimulated acid secretion from mammalian, avian or reptilian gastric mucosa. Histamine 112-121 histamine receptor H2 Homo sapiens 0-21 33931709-1 2021 Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Histamine 0-9 histamine receptor H2 Homo sapiens 22-25 191246-5 1976 This stimulatory effect of histamine was blocked by metiamide, a histamine H2-receptor antagonist, but not by chlorpheniramine, a histamine H1-receptor antagonist. Histamine 27-36 histamine receptor H2 Homo sapiens 65-86 964868-2 1976 Histamine-H2-receptor antagonists (Burimamide, Metiamide, Cimetidine) may inhibit histamine-stimulated gastric secretion in various species including man; in constrast, conventional antihistaminics (H1-antagonists) do not do so. Histamine 82-91 histamine receptor H2 Homo sapiens 0-21 60836-0 1976 [Proceedings: Effect of histamine-H2-receptor-blockaders on biosynthesis and catabolism of histamin e in gastric mucosa]. Histamine 91-101 histamine receptor H2 Homo sapiens 24-45 33625558-1 2021 We have previously shown that histamine (2-(1H-imidazol-4-yl)ethanamine) exerted concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic (H2R-TG) mice that overexpress the human H2 histamine receptor (H2R) in the heart; however, the effects were not seen in their wild-type (WT) littermates. Histamine 30-39 histamine receptor H2 Homo sapiens 280-306 33625558-1 2021 We have previously shown that histamine (2-(1H-imidazol-4-yl)ethanamine) exerted concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic (H2R-TG) mice that overexpress the human H2 histamine receptor (H2R) in the heart; however, the effects were not seen in their wild-type (WT) littermates. Histamine 41-71 histamine receptor H2 Homo sapiens 280-306 32333821-6 2021 Histamine, through histamine H2 receptor, increases i-cAMP levels and induces MRP4 transcript and protein levels in U937, KG1a, and HL-60 cells. Histamine 0-9 histamine receptor H2 Homo sapiens 19-40 32333821-7 2021 Moreover, histamine induces MRP4 promoter activity in HEK293T cells transfected with histamine H2 receptor (HEK293T-H2 R). Histamine 10-19 histamine receptor H2 Homo sapiens 85-106 30462522-8 2019 The bimodal functions of histamine include protumorigenic effects through H1R and antitumorigenic effects via H2R, and these results were supported by gene expression profiling studies on tumor specimens of patients with colorectal cancer. Histamine 25-34 histamine receptor H2 Homo sapiens 110-113 32764823-8 2020 Histamine increased the expression of H1R, H2R and H4R as well as of interleukin-6, cyclooxygenase-2, and prostaglandin-E2 secretion even without pressure application and induced receptor activator of NF-kB ligand (RANKL) protein expression with unchanged osteoprotegerin secretion. Histamine 0-9 histamine receptor H2 Homo sapiens 43-46 32932742-4 2020 Therefore, we created a model of the histamine-H2R-Gs complex based on the structure of the ternary complex of the beta2-adrenoceptor and investigated the conformational stability of this active GPCR conformation. Histamine 37-46 histamine receptor H2 Homo sapiens 47-50 32932742-9 2020 The cMD and GaMD simulations demonstrate that the active conformation is retained on a mus-timescale in the ternary histamine-H2R-Gs complex and in a truncated complex that contains only Gs helix alpha5 instead of the entire G protein. Histamine 116-125 histamine receptor H2 Homo sapiens 126-129 31718622-8 2019 RESULTS: The expression of four histamine receptors was significantly elevated in BPS/IC (H1R, P < 0.001; H2R, P = 0.031; H3R, P = 0.008; H4R, P = 0.048). Histamine 32-41 histamine receptor H2 Homo sapiens 109-112 30635130-8 2019 The memory recovery was mediated by the disinhibition of histamine release in the perirhinal cortex, which activated the histamine H2 receptor. Histamine 57-66 histamine receptor H2 Homo sapiens 121-142 30742585-3 2019 The pleiotropic effects of histamine are mediated by four types of receptors that belong to the G-protein-coupled receptor family: histamine H1 receptor (HRH-1), histamine H2 receptor, histamine H3 receptor, and histamine H4 receptor. Histamine 27-36 histamine receptor H2 Homo sapiens 162-183 29181106-4 2017 The enzyme activity of ALDH was upregulated by histamine and agonists of histamine H1 receptor (H1R) and histamine H2 receptor (H2R). Histamine 47-56 histamine receptor H2 Homo sapiens 105-126 28817204-2 2018 Recently, a number of H2 R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. Histamine 93-102 histamine receptor H2 Homo sapiens 22-26 28332048-5 2017 Histamine released from mast cells and basophils exerts its biological activities by activating four G protein-coupled receptors, namely H1R, H2R, H3R (expressed mainly in the brain), and the recently identified H4R. Histamine 0-9 histamine receptor H2 Homo sapiens 142-145 27316323-1 2016 BACKGROUND: Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Histamine 12-21 histamine receptor H2 Homo sapiens 31-52 27316323-1 2016 BACKGROUND: Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Histamine 12-21 histamine receptor H2 Homo sapiens 54-57 26989676-2 2016 However, the relevance of polymorphisms in histamine-related genes, such as HRH2, HRH3, DAO, and HNMT, with CHF remains largely neglected. Histamine 43-52 histamine receptor H2 Homo sapiens 76-80 27358232-3 2016 The four histamine receptor subtypes (H1R, H2R, H3R, and H4R) respond to the ligand histamine by activating three canonical heterotrimeric G-protein-mediated signaling pathways with a reported high degree of specificity. Histamine 9-18 histamine receptor H2 Homo sapiens 43-46 27271490-1 2016 BACKGROUND: Histamine is a key immunoregulatory mediator in immediate-type hypersensitivity reactions and chronic inflammatory responses, in particular histamine suppresses proinflammatory responses to bacterial ligands, through histamine receptor 2 (H2R). Histamine 12-21 histamine receptor H2 Homo sapiens 251-254 27271490-1 2016 BACKGROUND: Histamine is a key immunoregulatory mediator in immediate-type hypersensitivity reactions and chronic inflammatory responses, in particular histamine suppresses proinflammatory responses to bacterial ligands, through histamine receptor 2 (H2R). Histamine 152-161 histamine receptor H2 Homo sapiens 251-254 25725698-9 2015 Indeed, histamine elicited a sigmoid dose-response curve for IP3 production, shifted to the right by chlorpheniramine maleate, and elicited a double bell-shaped curve for cAMP production, partially suppressed by the selective H2R, H3R and H4R antagonists when each added alone, and completely ablated when combined together. Histamine 8-17 histamine receptor H2 Homo sapiens 226-229