PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1993899-2	1991	Nicotine, histamine, and vasoactive intestinal peptide each enhanced the rate of proenkephalin synthesis approximately 10-fold when examined between 16 and 32 h after the drug or hormone addition.	Histamine	10-19	proenkephalin	Bos taurus	81-94	
7693872-4	1993	Combinations of IBMX plus nicotine, VIP, or histamine also synergistically enhanced proenkephalin synthesis, with no further elevation when the cells were also pretreated with pertussis toxin.	Histamine	44-53	proenkephalin	Bos taurus	84-97	
1861155-5	1991	Pretreatment of the cells with nicotine, histamine, or vasoactive intestinal peptide to enhance the rate of proenkephalin synthesis failed to alter the time course of processing and had minimal effects on the distribution of products formed.	Histamine	41-50	proenkephalin	Bos taurus	108-121	
3681292-3	1987	Moreover, histamine also produced a profound compensatory increase in cellular peptide content after 48 h of exposure, most likely caused by a four- to fivefold increase in the mRNA levels coding for the proenkephalin A precursor.	Histamine	10-19	proenkephalin	Bos taurus	204-219	
2229066-1	1990	Stimulation of cultured bovine chromaffin cells with histamine (10(-5) M), nicotine (10(-6) M), and veratridine (2 x 10(-6) M) results in a time-dependent up to 5-fold increase in proenkephalin (Penk) mRNA levels.	Histamine	53-62	proenkephalin	Bos taurus	180-193	
2229066-1	1990	Stimulation of cultured bovine chromaffin cells with histamine (10(-5) M), nicotine (10(-6) M), and veratridine (2 x 10(-6) M) results in a time-dependent up to 5-fold increase in proenkephalin (Penk) mRNA levels.	Histamine	53-62	proenkephalin	Bos taurus	195-199	
2229066-3	1990	Similarly, incubation of chromaffin cells with cycloheximide (10(-6) M), given at 0-6 h, blocks the increase in Penk mRNA after stimulation with histamine and nicotine indicating that ongoing protein synthesis is necessary for the delayed rise of Penk mRNA.	Histamine	145-154	proenkephalin	Bos taurus	112-116	
2229066-4	1990	Nuclear run-off experiments revealed high transcription levels of the Penk gene (3-fold at 2 h) and the tyrosine hydroxylase gene (7-fold at 20 min) following stimulation with histamine, which was not observed in the presence of cycloheximide (10(-5) M).	Histamine	176-185	proenkephalin	Bos taurus	70-74	
2767138-0	1989	Histamine activates proenkephalin A mRNA but not phenylethanolamine N-methyltransferase mRNA expression in cultured bovine adrenal chromaffin cells.	Histamine	0-9	proenkephalin	Bos taurus	20-35	
2767138-1	1989	The effects of histamine on the regulation of proenkephalin A (ProEnk A) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression were examined in cultures of bovine adrenal chromaffin cells.	Histamine	15-24	proenkephalin	Bos taurus	46-61	
2767138-1	1989	The effects of histamine on the regulation of proenkephalin A (ProEnk A) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression were examined in cultures of bovine adrenal chromaffin cells.	Histamine	15-24	proenkephalin	Bos taurus	63-71	
2767138-2	1989	Prolonged incubation with histamine resulted in a concentration-dependent increase in the levels of ProEnk A mRNA with little effect on the levels of PNMT mRNA.	Histamine	26-35	proenkephalin	Bos taurus	100-108	
2767138-3	1989	The activation of ProEnK A mRNA by histamine followed a slow time course, reaching 2-3 fold basal levels after 48 h incubation.	Histamine	35-44	proenkephalin	Bos taurus	18-26	
2767138-6	1989	In the presence of the calcium channel blocker D600, the histamine-induced increase in ProEnk A mRNA was greatly reduced, though not abolished.	Histamine	57-66	proenkephalin	Bos taurus	87-95	
2767138-9	1989	The differential effects of histamine on ProEnk A mRNA and PNMT mRNA expression suggest that different regulatory mechanisms are called upon to regulate the synthesis of opioid peptides and adrenaline in response to stimulation of the chromaffin cells.	Histamine	28-37	proenkephalin	Bos taurus	41-49	
3681292-4	1987	All the histamine-induced effects (acute release, changes in peptide cell content, proenkephalin A mRNA levels) are antagonized by the H1-receptor antagonist, clemastine, whereas the H2-receptor antagonists, ranitidine and cimetidine, were less effective (approximately 20% inhibition).	Histamine	8-17	proenkephalin	Bos taurus	83-98	
2441311-1	1987	The effect of histamine on messenger ribonucleic acid levels encoding proenkephalin A (mRNA(enk)) was studied in serum-free cultures of bovine adrenal chromaffin cells.	Histamine	14-23	proenkephalin	Bos taurus	70-85