PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16491014-8 2006 Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8. Histamine 107-116 mitogen-activated protein kinase 1 Homo sapiens 70-73 18682391-0 2008 Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cdelta-dependent ERK activation pathway. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 130-133 18682391-5 2008 Histamine also rapidly and transiently activates protein kinase C-delta (PKCdelta), extracellular signal-regulated kinase (ERK)1/2, p38 kinase, and c-Jun N-terminal kinase (JNK) prior to Egr-1 induction. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 123-126 18682391-5 2008 Histamine also rapidly and transiently activates protein kinase C-delta (PKCdelta), extracellular signal-regulated kinase (ERK)1/2, p38 kinase, and c-Jun N-terminal kinase (JNK) prior to Egr-1 induction. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 132-135 18682391-6 2008 Using specific pharmacological inhibitors and small interfering RNA technology, we determined that PKCdelta and ERK, but not p38 and JNK, mediate histamine-induced Egr-1 expression. Histamine 146-155 mitogen-activated protein kinase 1 Homo sapiens 112-115 18682391-8 2008 The present study reveals the following regulatory mechanism: histamine up-regulates Egr-1 expression in primary HAECs via the H1 receptor and the PKCdelta-dependent ERK activation pathway. Histamine 62-71 mitogen-activated protein kinase 1 Homo sapiens 166-169 16491014-8 2006 Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8. Histamine 107-116 mitogen-activated protein kinase 1 Homo sapiens 125-128 16491014-12 2006 CONCLUSIONS: The H1R-PKC-ERK pathway may play crucial roles in eliciting cytokine production from bronchial epithelial cells stimulated by histamine, leading to airway inflammation. Histamine 139-148 mitogen-activated protein kinase 1 Homo sapiens 25-28 16009787-8 2005 Histamine induced a time-dependent, H1 receptor-mediated activation of p38 MAP kinase (p38), p44/42 MAP kinase (ERK), and c-jun terminal NH2 kinase (JNK). Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 112-115 16491014-0 2006 Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C. BACKGROUND: Histamine stimulates the release of several cytokines, such as interleukin (IL)-8 and granulocyte macrophage colony-stimulating factor, from bronchial epithelial cells. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 150-187 15652235-11 2005 Furthermore, in addition to the above cytokines, histamine stimulated the biosynthesis and/or release of numerous keratinocyte-derived mediators, which are probably regulated by the ERK or NF-kappa B cascades. Histamine 49-58 mitogen-activated protein kinase 1 Homo sapiens 182-185 15652235-0 2005 Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/I kappa B/NF-kappa B signal cascades. Histamine 40-49 mitogen-activated protein kinase 1 Homo sapiens 157-160 15652235-12 2005 Our study suggests that histamine activates Ca(2+)-dependent PKC isoforms that play crucial roles in the activation of Raf/MEK/ERK and IKK/I kappa B/NF-kappa B cascades, leading to up-regulation of cytokine expression. Histamine 24-33 mitogen-activated protein kinase 1 Homo sapiens 127-130 33148907-6 2020 Dexamethasone suppressed basal levels of H1R mRNA, and histamine-induced up-regulation of H1R mRNA and ERK phosphorylation in HeLa cells. Histamine 55-64 mitogen-activated protein kinase 1 Homo sapiens 103-106 15652235-6 2005 Histamine activated the phosphorylation of protein kinase C (PKC), c-Raf, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), I kappa B kinase (IKK), inhibitory kappa B (I kappa B)-alpha and nuclear factor-KB (NF-kappa B) p65, which was inhibited by Ro-31-8220, a PKC inhibitor. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 100-137 15652235-6 2005 Histamine activated the phosphorylation of protein kinase C (PKC), c-Raf, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), I kappa B kinase (IKK), inhibitory kappa B (I kappa B)-alpha and nuclear factor-KB (NF-kappa B) p65, which was inhibited by Ro-31-8220, a PKC inhibitor. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 191-194 35107584-6 2022 By using G protein inhibitors, we observed that Gq mediated the ERK and Akt responses to histamine. Histamine 89-98 mitogen-activated protein kinase 1 Homo sapiens 64-67 14534235-0 2003 Improvement in fear memory by histamine-elicited ERK2 activation in hippocampal CA3 cells. Histamine 30-39 mitogen-activated protein kinase 1 Homo sapiens 49-53 33148907-7 2020 These data suggested that corticosteroid inhibited both basal transcription and histamine-induced transcriptional activation of H1R through its suppression of ERK phosphorylation in the signaling pathway involved in H1R gene transcription. Histamine 80-89 mitogen-activated protein kinase 1 Homo sapiens 159-162 25374757-11 2014 The p38 inhibitor strongly attenuated IL-6 production in histamine-stimulated nasal fibroblasts. Histamine 57-66 mitogen-activated protein kinase 1 Homo sapiens 4-7 27871651-5 2016 Live cell imaging, FRET and FRAP measurements along with functional analysis reveal that pERK generated by histamine activation is physically and functionally restricted in the cytosol and the findings report a spatial regulation of MAPK cascade activated non-canonically through GPCRs unlike its canonical activation by EGF. Histamine 107-116 mitogen-activated protein kinase 1 Homo sapiens 233-237 26440050-8 2016 We further demonstrate that several intracellular signaling pathways are involved in histamine-induced TR3 transcript variants, including histamine receptor H1-mediated phospholipase C (PLC)/calcium /calcineurin/protein kinase C (PKC)/protein kinase D (PKD) pathway and ERK pathway, as well as histamine receptor H3-mediated PKC-ERK pathway. Histamine 85-94 mitogen-activated protein kinase 1 Homo sapiens 270-273 26440050-8 2016 We further demonstrate that several intracellular signaling pathways are involved in histamine-induced TR3 transcript variants, including histamine receptor H1-mediated phospholipase C (PLC)/calcium /calcineurin/protein kinase C (PKC)/protein kinase D (PKD) pathway and ERK pathway, as well as histamine receptor H3-mediated PKC-ERK pathway. Histamine 85-94 mitogen-activated protein kinase 1 Homo sapiens 329-332 25374757-0 2014 Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-kappaB Pathways in Nasal Fibroblasts. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 60-63 25374757-9 2014 Histamine increased the expression level of phosphorylated p38 (pp38), pERK, and pJNK, as well as NF-kappaB induction. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 59-62 30021868-6 2018 Histamine-induced migration of mast cells was also sensitive to PD98059, an inhibitor of the mitogen-activated protein kinase kinase, indicating that the Rac-ERK pathway was involved in chemotaxis through the H4 receptor. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 158-161 27316323-1 2016 BACKGROUND: Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Histamine 12-21 mitogen-activated protein kinase 1 Homo sapiens 160-163 24477236-8 2014 Histamine-induced ERK activation was also inhibited by atorvastatin pretreatment, while simvastatin further inhibited histamine-induced vascular endothelial cadherin phosphorylation as well as altered HUVEC morphology and inhibited actin polymerization. Histamine 0-9 mitogen-activated protein kinase 1 Homo sapiens 18-21 23782309-9 2014 It was also observed that the ability of BPA to enhance histamine and CysLT release was inhibited by blocking the extracellular signal-regulated kinase (ERK) pathway with U0126 or by chelating extracellular calcium (Ca(2+)) using EGTA. Histamine 56-65 mitogen-activated protein kinase 1 Homo sapiens 114-151 23782309-9 2014 It was also observed that the ability of BPA to enhance histamine and CysLT release was inhibited by blocking the extracellular signal-regulated kinase (ERK) pathway with U0126 or by chelating extracellular calcium (Ca(2+)) using EGTA. Histamine 56-65 mitogen-activated protein kinase 1 Homo sapiens 153-156 21730054-16 2011 These results suggest the involvement of the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells. Histamine 109-118 mitogen-activated protein kinase 1 Homo sapiens 54-57 19734018-3 2009 We previously showed that histamine enhanced transcriptional activity of activator protein-1 (AP-1) in human keratinocytes by inducing the expression of AP-1 component c-Fos via the activation of extracellular signal-regulated kinase (ERK) through H1 receptors. Histamine 26-35 mitogen-activated protein kinase 1 Homo sapiens 196-233 19734018-3 2009 We previously showed that histamine enhanced transcriptional activity of activator protein-1 (AP-1) in human keratinocytes by inducing the expression of AP-1 component c-Fos via the activation of extracellular signal-regulated kinase (ERK) through H1 receptors. Histamine 26-35 mitogen-activated protein kinase 1 Homo sapiens 235-238 19734018-14 2009 CONCLUSION: It is suggested that histamine induces hBD-3 production in human keratinocytes through H1 receptors by activating STAT3 and AP-1 via JAK2 and MEK/ERK. Histamine 33-42 mitogen-activated protein kinase 1 Homo sapiens 158-161