PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16936117-12 2006 The histamine-induced MLC phosphorylation was reduced by pre-exposure to either ML-7 (50 microM), an MLCK (MLC kinase) inhibitor, or chelerythrine (10 microM), an inhibitor of PKC. Histamine 4-13 myosin light chain kinase, smooth muscle Bos taurus 101-105 16936117-12 2006 The histamine-induced MLC phosphorylation was reduced by pre-exposure to either ML-7 (50 microM), an MLCK (MLC kinase) inhibitor, or chelerythrine (10 microM), an inhibitor of PKC. Histamine 4-13 myosin light chain kinase, smooth muscle Bos taurus 107-117 16936117-15 2006 CONCLUSIONS: Histamine induces MLC phosphorylation by activating MLCK and partly inhibiting MLC phosphatase. Histamine 13-22 myosin light chain kinase, smooth muscle Bos taurus 65-69 16936117-19 2006 Last, elevated cAMP prevents histamine-induced loss of the barrier integrity, not only by blocking inactivation of MLC phosphatase but also by inactivating MLCK. Histamine 29-38 myosin light chain kinase, smooth muscle Bos taurus 156-160