PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 45-54 interleukin 18 Homo sapiens 18-23 17716784-4 2008 Under certain conditions, however, stress hormones, substance P, ATP and the activation of the corticotropin-releasing hormone/substance P-histamine axis may actually facilitate inflammation, through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor (TNF)-alpha and CRP production. Histamine 139-148 interleukin 18 Homo sapiens 245-250 15207779-0 2004 Histamine inhibits lipopolysaccharide-induced interleukin (IL)-18 production in human monocytes. Histamine 0-9 interleukin 18 Homo sapiens 46-65 15207779-3 2004 In the present study, we found that LPS at relatively high concentrations (10-1000 ng/ml) induced IL-18 production in a concentration-dependent manner both in monocytes isolated from PBMC, and that histamine (10(-7) to 10(-4) M) inhibited IL-18 production induced by LPS. Histamine 198-207 interleukin 18 Homo sapiens 98-103 14527086-3 2003 Somewhat paradoxically, IL-18 also has the capacity to induce allergic responses via induction of IL-4 production by T helper cells and to activate mast cells and basophils to release atopic effector molecules such as histamine. Histamine 218-227 interleukin 18 Homo sapiens 24-29 12829919-10 2003 In the previous study, histamine inhibited ICAM-1 expression in the presence of IL-18 but had no effect in the absence of IL-18. Histamine 23-32 interleukin 18 Homo sapiens 80-85 17509061-5 2007 However, in ASST-positive patients, IL-18 levels paralleled clinical severity scores and showed a tendency to correlate with in vitro histamine release. Histamine 134-143 interleukin 18 Homo sapiens 36-41 12364868-0 2002 Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18. Histamine 10-19 interleukin 18 Homo sapiens 167-181 12364868-4 2002 We also investigated the modulatory effects of histamine on IL-18 action because histamine has been demonstrated to be a modulator of IL-18 effect and a mediator of inflammation. Histamine 81-90 interleukin 18 Homo sapiens 134-139 12364868-9 2002 Histamine concentration-dependently inhibited ICAM-1 expression and cytokine production in MLR stimulated with IL-18, whereas histamine alone did not show any effects on these responses in the absence of IL-18. Histamine 0-9 interleukin 18 Homo sapiens 111-116 12364868-12 2002 The fact that histamine could inhibit the IL-18-stimulated MLR implies that immunomodulation by histamine and selective H2-receptor agonists may have an important role in future immunosuppressive strategies. Histamine 14-23 interleukin 18 Homo sapiens 42-47 12364868-12 2002 The fact that histamine could inhibit the IL-18-stimulated MLR implies that immunomodulation by histamine and selective H2-receptor agonists may have an important role in future immunosuppressive strategies. Histamine 96-105 interleukin 18 Homo sapiens 42-47 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interleukin 18 Homo sapiens 108-113 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 116-125 interleukin 18 Homo sapiens 18-23 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 15-24 interleukin 18 Homo sapiens 64-69 11496824-4 2001 Using human PBMC culture, it was demonstrated that histamine was a potent inducer of IL-18, IFN-gamma in human PBMC. Histamine 51-60 interleukin 18 Homo sapiens 85-90 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 15-24 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 15-24 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 64-69 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 64-69 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11174201-2 2001 Recently, it was reported that histamine induced IL-18 and that IL-18 might act as a coinducer of TH1 and TH2 cytokines. Histamine 31-40 interleukin 18 Homo sapiens 49-54 11174201-2 2001 Recently, it was reported that histamine induced IL-18 and that IL-18 might act as a coinducer of TH1 and TH2 cytokines. Histamine 31-40 interleukin 18 Homo sapiens 64-69 10843724-0 2000 Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells. Histamine 0-9 interleukin 18 Homo sapiens 33-38 10843724-1 2000 Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine 0-9 interleukin 18 Homo sapiens 82-87 10843724-5 2000 The EC50 values of histamine, 4-methylhistamine, and dimaprit for the production of IL-18 were 1.5, 1.0, and 3.8 microM, respectively. Histamine 19-28 interleukin 18 Homo sapiens 84-89 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 15-24 interleukin 18 Homo sapiens 98-103 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 15-24 interleukin 18 Homo sapiens 218-223 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 15-24 interleukin 18 Homo sapiens 218-223 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 178-187 interleukin 18 Homo sapiens 98-103 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 178-187 interleukin 18 Homo sapiens 218-223 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 178-187 interleukin 18 Homo sapiens 218-223 10843724-9 2000 IFN-gamma production induced by IL-18 was inhibited by anti-IL-12 Ab, showing the marked contrast of the effect of histamine. Histamine 115-124 interleukin 18 Homo sapiens 32-37 10843724-10 2000 Thus histamine is a very important modulator of Th1 cytokine production in PBMCs and is quite unique in triggering IL-18-initiating cytokine cascade without inducing IL-12 production. Histamine 5-14 interleukin 18 Homo sapiens 115-120 30717382-6 2019 Furthermore, together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Histamine 130-139 interleukin 18 Homo sapiens 33-38 29731751-8 2018 Together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Histamine 117-126 interleukin 18 Homo sapiens 20-25