PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15099528-8	2004	These results suggest that (i) in liver, lung and spleen, either the major cells supplying histamine via HDC induction in response to LPS and IL-1 are not mast cells, or mast cells are not a prerequisite for the induction of HDC; (ii) the cells in which HDC is induced by LPS and IL-1 are similar or identical in a given organ; and (iii) neither IL-1 nor TNF-alpha is a prerequisite for the induction of HDC by LPS.	Histamine	91-100	interleukin 1 complex	Mus musculus	142-146	
16203021-0	2006	Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate.	Histamine	44-53	interleukin 1 complex	Mus musculus	138-142	
2165034-0	1990	Possible involvement of adenosine 3":5"-cyclic monophosphate and extracellular calcium ions in histamine stimulation of interleukin-1 release from macrophage-like P388D1 cells.	Histamine	95-104	interleukin 1 complex	Mus musculus	120-133	
7712016-2	1995	Our previous work has shown that injection into mice of lipopolysaccharide (LPS) and the cytokines interleukin 1 (IL-1) and tumour necrosis factor (TNF) induces histidine decarboxylase (HDC), the enzyme forming histamine, in various tissues such as liver, lung, spleen and bone marrow, but not in the blood.	Histamine	211-220	interleukin 1 complex	Mus musculus	99-118	
2312155-4	1990	IL-1 production was significantly blocked by either an H1 anti-histamine, diphenhydramine, or H2 anti-histamine ranitidine, in the absence of any exogenous histamine.	Histamine	63-72	interleukin 1 complex	Mus musculus	0-4	
2312155-4	1990	IL-1 production was significantly blocked by either an H1 anti-histamine, diphenhydramine, or H2 anti-histamine ranitidine, in the absence of any exogenous histamine.	Histamine	102-111	interleukin 1 complex	Mus musculus	0-4	
2312155-5	1990	Addition of exogenous histamine accentuated the IL-1 production by macrophages as a function of its dose.	Histamine	22-31	interleukin 1 complex	Mus musculus	48-52	
2312155-6	1990	These results suggest that IL-1 production by mouse peritoneal macrophages is regulated by histamine synthesized in the system per se and that the effect of histamine is dependent on both H1 and H2 histamine receptors located on the surface of the cells.	Histamine	91-100	interleukin 1 complex	Mus musculus	27-31	
2784963-6	1989	These results suggest that the syntheses of histamine and putrescine are regulated by IL-1 and/or TNF alpha in inflammatory or immune responses.	Histamine	44-53	interleukin 1 complex	Mus musculus	86-90