PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6379050-15 1984 Lymphocytes incubated with histamine and diphenhydramine produced LCF but neither LyMIF, whereas cells incubated with histamine in the presence of cimetidine produced both LyMIF but not LCF. Histamine 27-36 interleukin 16 Homo sapiens 66-69 12235264-0 2002 Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. Histamine 42-51 interleukin 16 Homo sapiens 60-74 12235264-1 2002 Histamine is known to trigger the release of interleukin (IL)-16 from human CD8(+) cells. Histamine 0-9 interleukin 16 Homo sapiens 45-64 12235264-3 2002 Histamine stimulation of human CD8(+) T lymphocytes purified from peripheral blood led to a 5- to 8-fold increase in the basal release of IL-16 within 24 h, and this increase was significantly blocked by the H(2)-selective antagonist, cimetidine, or by thioperamide, an antagonist of H(3) and H(4) receptors, respectively. Histamine 0-9 interleukin 16 Homo sapiens 138-143 11264709-8 2001 Histamine induces IL-16 production by CD8+ cells and airway epithelial cells; IL-16 is an important early chemotactic factor for CD4+ lymphocytes. Histamine 0-9 interleukin 16 Homo sapiens 18-23 10572065-5 1999 BEAS-2B constitutively expressed IL-16 messenger RNA (mRNA) and protein; IL-16 expression was significantly upregulated in a concentration-dependent manner within 24 h by stimulation with histamine, IL-1beta, or tumor necrosis factor (TNF)-alpha whereas interferon-gamma did not significantly increase IL-16. Histamine 188-197 interleukin 16 Homo sapiens 33-38 10572065-5 1999 BEAS-2B constitutively expressed IL-16 messenger RNA (mRNA) and protein; IL-16 expression was significantly upregulated in a concentration-dependent manner within 24 h by stimulation with histamine, IL-1beta, or tumor necrosis factor (TNF)-alpha whereas interferon-gamma did not significantly increase IL-16. Histamine 188-197 interleukin 16 Homo sapiens 73-78 10572065-5 1999 BEAS-2B constitutively expressed IL-16 messenger RNA (mRNA) and protein; IL-16 expression was significantly upregulated in a concentration-dependent manner within 24 h by stimulation with histamine, IL-1beta, or tumor necrosis factor (TNF)-alpha whereas interferon-gamma did not significantly increase IL-16. Histamine 188-197 interleukin 16 Homo sapiens 73-78 10572065-10 1999 This combination of cytokines also had a priming effect on histamine-induced IL-16 mRNA expression, which was observed within 24 h and which increased to at least 48 h after stimulation. Histamine 59-68 interleukin 16 Homo sapiens 77-82 10572065-11 1999 The IL-16 expression induced by histamine and combined cytokines was significantly inhibited by pretreatment with the protein synthesis inhibitor cycloheximide (10 microg/ml). Histamine 32-41 interleukin 16 Homo sapiens 4-9 10572065-14 1999 These findings suggest that bronchial epithelial cells have the capacity to produce IL-16 after stimulation with histamine, IL-1beta, and TNF-alpha, and raise the possibility that epithelium-derived IL-16 may play a role in recruitment of eosinophils and CD4(+) T lymphocytes in the airways. Histamine 113-122 interleukin 16 Homo sapiens 84-89 9648706-0 1998 Identification of IL-16 as the lymphocyte chemotactic activity in the bronchoalveolar lavage fluid of histamine-challenged asthmatic patients. Histamine 102-111 interleukin 16 Homo sapiens 18-23 9648706-2 1998 Because IL-16 is released in vitro after histamine stimulation of CD8+ T cells and epithelial cells, we evaluated the potential role of histamine in the release of IL-16 into the airways of allergic asthmatics in vivo. Histamine 136-145 interleukin 16 Homo sapiens 164-169 9648706-5 1998 In six of the eight atopic asthmatic subjects, the histamine-challenged but not saline-challenged segment contained IL-16 chemotactic activity but no other identifiable lymphocyte chemoattractant activities at 6 hours. Histamine 51-60 interleukin 16 Homo sapiens 116-121 9648706-6 1998 CONCLUSIONS: IL-16 appears in the airways after histamine challenge and therefore could contribute to the earliest infiltration of CD4+ T cells and eosinophils observed after antigen challenge due to histamine release from mast cells. Histamine 48-57 interleukin 16 Homo sapiens 13-18 9648706-6 1998 CONCLUSIONS: IL-16 appears in the airways after histamine challenge and therefore could contribute to the earliest infiltration of CD4+ T cells and eosinophils observed after antigen challenge due to histamine release from mast cells. Histamine 200-209 interleukin 16 Homo sapiens 13-18 7673707-0 1995 Histamine-induced secretion of lymphocyte chemoattractant factor from CD8+ T cells is independent of transcription and translation. Histamine 0-9 interleukin 16 Homo sapiens 31-64 7673707-2 1995 We have reported previously that histamine induces the release of the CD4+ cell-specific lymphocyte chemoattractant factor (LCF) into the culture supernatants of CD8+ cells between 1 and 4 h following stimulation. Histamine 33-42 interleukin 16 Homo sapiens 89-122 7673707-2 1995 We have reported previously that histamine induces the release of the CD4+ cell-specific lymphocyte chemoattractant factor (LCF) into the culture supernatants of CD8+ cells between 1 and 4 h following stimulation. Histamine 33-42 interleukin 16 Homo sapiens 124-127 7673707-3 1995 To determine the mechanism of histamine-induced secretion of LCF, we evaluated the effects of inhibitors of gene transcription and translation on LCF production, and determined the effects of histamine stimulation on LCF mRNA induction and stability. Histamine 30-39 interleukin 16 Homo sapiens 61-64 7673707-4 1995 The histamine-induced secretion of LCF from CD8+ cells was not associated with de novo synthesis of protein, nor did histamine have an effect on the induction or stability of LCF mRNA. Histamine 4-13 interleukin 16 Homo sapiens 35-38 7673707-6 1995 The only detectable lymphocyte chemoattractant present in unstimulated cells was LCF, and histamine induced the secretion of LCF, but no other lymphocyte chemoattractant activities, within 4 h. These studies demonstrate that histamine can act as a secretagogue for the protein LCF, which is constitutively synthesized and present in a biologically active form in CD8+ T cells. Histamine 90-99 interleukin 16 Homo sapiens 125-128 7673707-6 1995 The only detectable lymphocyte chemoattractant present in unstimulated cells was LCF, and histamine induced the secretion of LCF, but no other lymphocyte chemoattractant activities, within 4 h. These studies demonstrate that histamine can act as a secretagogue for the protein LCF, which is constitutively synthesized and present in a biologically active form in CD8+ T cells. Histamine 90-99 interleukin 16 Homo sapiens 125-128 7673707-6 1995 The only detectable lymphocyte chemoattractant present in unstimulated cells was LCF, and histamine induced the secretion of LCF, but no other lymphocyte chemoattractant activities, within 4 h. These studies demonstrate that histamine can act as a secretagogue for the protein LCF, which is constitutively synthesized and present in a biologically active form in CD8+ T cells. Histamine 225-234 interleukin 16 Homo sapiens 81-84 7673707-6 1995 The only detectable lymphocyte chemoattractant present in unstimulated cells was LCF, and histamine induced the secretion of LCF, but no other lymphocyte chemoattractant activities, within 4 h. These studies demonstrate that histamine can act as a secretagogue for the protein LCF, which is constitutively synthesized and present in a biologically active form in CD8+ T cells. Histamine 225-234 interleukin 16 Homo sapiens 125-128 7673707-6 1995 The only detectable lymphocyte chemoattractant present in unstimulated cells was LCF, and histamine induced the secretion of LCF, but no other lymphocyte chemoattractant activities, within 4 h. These studies demonstrate that histamine can act as a secretagogue for the protein LCF, which is constitutively synthesized and present in a biologically active form in CD8+ T cells. Histamine 225-234 interleukin 16 Homo sapiens 125-128 7673707-7 1995 The rapid appearance of LCF induced by histamine may represent a mechanism for recruitment and activation for CD4+ cells in diseases such as asthma. Histamine 39-48 interleukin 16 Homo sapiens 24-27