PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24118885-0 2014 Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial. AZD7687 49-56 diacylglycerol O-acyltransferase 1 Homo sapiens 0-32 24118885-9 2014 CONCLUSIONS: Altered lipid handling and hormone secretion in the gut were demonstrated during 1-week treatment with the DGAT1 inhibitor AZD7687. AZD7687 136-143 diacylglycerol O-acyltransferase 1 Homo sapiens 120-125 24118885-2 2014 This randomized, placebo-controlled, phase 1 study in 62 overweight or obese men explored the effects and tolerability of AZD7687, a reversible and selective DGAT1 inhibitor. AZD7687 122-129 diacylglycerol O-acyltransferase 1 Homo sapiens 158-163 23116186-0 2012 Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). AZD7687 197-204 diacylglycerol O-acyltransferase 1 Homo sapiens 67-99 22950654-0 2013 Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study. AZD7687 43-50 diacylglycerol O-acyltransferase 1 Homo sapiens 27-32 22950654-2 2013 This first-time-in-human single ascending dose study explored the safety, tolerability, pharmacokinetics and pharmacodynamics of the selective DGAT1 inhibitor AZD7687. AZD7687 159-166 diacylglycerol O-acyltransferase 1 Homo sapiens 143-148 22950654-12 2013 CONCLUSIONS: The attenuating effect of AZD7687 on postprandial TAG excursion provides proof of mechanism with respect to gut DGAT1 inhibition. AZD7687 39-46 diacylglycerol O-acyltransferase 1 Homo sapiens 125-130 23116186-0 2012 Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). AZD7687 197-204 diacylglycerol O-acyltransferase 1 Homo sapiens 101-106