PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16403819-12 2006 The insulin secretion measured in the supernatant was the same whether INS-1 cells were treated by dopamine or Lodosyn or untreated. Carbidopa 111-118 insulin Homo sapiens 4-11 15258132-0 2004 Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle. Carbidopa 14-23 insulin Homo sapiens 91-98 15258132-1 2004 We hypothesized that levodopa with carbidopa, a common therapy for patients with Parkinson"s disease, might contribute to the high prevalence of insulin resistance reported in patients with Parkinson"s disease. Carbidopa 35-44 insulin Homo sapiens 145-152 15258132-5 2004 Levodopa-carbidopa also inhibited the insulin-stimulated increase in glycogen synthase activity, whereas propranolol attenuated this effect. Carbidopa 9-18 insulin Homo sapiens 38-45 15258132-6 2004 Insulin-stimulated tyrosine phosphorylation of insulin receptor substrate (IRS)-1 was reduced by levodopa-carbidopa, although Akt phosphorylation was unaffected by levodopa-carbidopa. Carbidopa 106-115 insulin Homo sapiens 0-7 15258132-6 2004 Insulin-stimulated tyrosine phosphorylation of insulin receptor substrate (IRS)-1 was reduced by levodopa-carbidopa, although Akt phosphorylation was unaffected by levodopa-carbidopa. Carbidopa 173-182 insulin Homo sapiens 0-7 15258132-11 2004 The data demonstrate beta-adrenergic-dependent inhibition of insulin action by levodopa-carbidopa and suggest that unrecognized insulin resistance may exist in chronically treated patients with Parkinson"s disease. Carbidopa 88-97 insulin Homo sapiens 61-68