PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12015979-2 2002 An unusual sequence arrangement of two AG dinucleotides and an intervening polypyrimidine (Py)-tract at the 3" end of intron 2 is important for Sxl autoregulation. polypyrimidine 75-89 Sex lethal Drosophila melanogaster 144-147 7680770-5 1993 Here we show that Sxl inhibits splicing to the non-sex-specific (default) site by specifically binding to its polypyrimidine tract, blocking the binding of the essential splicing factor U2AF. polypyrimidine 110-124 Sex lethal Drosophila melanogaster 18-21 12554879-0 2003 Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF65) recognize polypyrimidine tracts using multiple modes of binding. polypyrimidine 86-100 Sex lethal Drosophila melanogaster 0-10 11565743-2 2001 We have previously shown that SXL blocks the binding of U2 auxiliary factor (U2AF) to the polypyrimidine (Py)-tract associated with the 3" splice site of the regulated intron. polypyrimidine 90-104 Sex lethal Drosophila melanogaster 30-33 10617208-2 1999 Here we report that splicing inhibition of msl-2 requires a binding site for SXL at the polypyrimidine (poly(Y)) tract associated with the 3" splice site, and an unusually long distance between the poly(Y) tract and the conserved AG dinucleotide at the 3" end of the intron. polypyrimidine 88-102 Sex lethal Drosophila melanogaster 77-80 10217141-1 1999 The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative splicing of the transformer (tra) messenger RNA precursor by binding to the tra polypyrimidine tract during the sex-determination process. polypyrimidine 158-172 Sex lethal Drosophila melanogaster 4-14 10217141-1 1999 The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative splicing of the transformer (tra) messenger RNA precursor by binding to the tra polypyrimidine tract during the sex-determination process. polypyrimidine 158-172 Sex lethal Drosophila melanogaster 16-19 7556096-2 1995 In part, Sxl functions by regulating the splicing of the transformer pre-mRNA by binding to a 3" splice site polypyrimidine tract. polypyrimidine 109-123 Sex lethal Drosophila melanogaster 9-12 7556096-10 1995 Interestingly, in vitro Sxl bound with equal affinity to polypyrimidine tracts of pre-mRNAs that it does not regulate in vivo. polypyrimidine 57-71 Sex lethal Drosophila melanogaster 24-27 7556096-11 1995 We discuss the implications of this finding for the mechanism through which Sxl may gain selectivity for particular polypyrimidine tracts in vivo. polypyrimidine 116-130 Sex lethal Drosophila melanogaster 76-79