PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33481175-1 2021 PURPOSE: To assess in healthy volunteers the whole-body distribution and dosimetry of [11C]metoclopramide, a new positron emission tomography (PET) tracer to measure P-glycoprotein activity at the blood-brain barrier. Metoclopramide 91-105 ATP binding cassette subfamily B member 1 Homo sapiens 166-180 32200996-4 2020 Three radiolabeled substrates of the P-gp have been developed for clinical use: [11C]verapamil, [11C]-N-desmethyl-loperamide and [11C]metoclopramide. Metoclopramide 134-148 ATP binding cassette subfamily B member 1 Homo sapiens 37-41 31853677-1 2019 BACKGROUND: [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. Metoclopramide 12-31 ATP binding cassette subfamily B member 1 Homo sapiens 87-101 29748235-2 2018 Many drugs, such as metoclopramide, are weak ABCB1 substrates and distribute into the brain even when ABCB1 is fully functional. Metoclopramide 20-34 ATP binding cassette subfamily B member 1 Homo sapiens 45-50 29748235-2 2018 Many drugs, such as metoclopramide, are weak ABCB1 substrates and distribute into the brain even when ABCB1 is fully functional. Metoclopramide 20-34 ATP binding cassette subfamily B member 1 Homo sapiens 102-107 26585058-0 2016 Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide. Metoclopramide 83-97 ATP binding cassette subfamily B member 1 Homo sapiens 26-40 26585058-0 2016 Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide. Metoclopramide 83-97 ATP binding cassette subfamily B member 1 Homo sapiens 42-47