PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33014856-0	2020	Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway.	cordycepin	15-25	AKT serine/threonine kinase 1	Homo sapiens	105-108	
34953496-14	2021	CONCLUSIONS: In brief, this study provides comprehensive evidence that cordycepin inhibits osteosarcoma cell growth and invasion and induces osteosarcoma cell apoptosis by activating AMPK and inhibiting the AKT/mTOR signaling pathway and enhances the sensitivity of osteosarcoma cells to cisplatin, suggesting that cordycepin is a promising treatment for osteosarcoma.	cordycepin	71-81	AKT serine/threonine kinase 1	Homo sapiens	207-210	
33520990-0	2020	Cordycepin Reverses Cisplatin Resistance in Non-small Cell Lung Cancer by Activating AMPK and Inhibiting AKT Signaling Pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	105-108	
33014856-7	2020	The VEGF/PI3K/Akt pathway was inhibited after treatment with cordycepin and apatinib.	cordycepin	61-71	AKT serine/threonine kinase 1	Homo sapiens	14-17	
33014856-8	2020	Conclusion: Our findings demonstrated that the combination of cordycepin and apatinib has synergistically anticancer effect on NSCLC cells by down-regulating VEGF/PI3K/Akt signaling pathway.	cordycepin	62-72	AKT serine/threonine kinase 1	Homo sapiens	168-171	
28962164-5	2017	Cordycepin significantly inhibited the TNF-alpha-induced mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF-alpha-induced expression level of nuclear factor (NF)-kappaB p65 and markedly prevented the TNF-alpha-associated degradation of IkappaBalpha in HA-VSMCs.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	119-122	
31527329-0	2019	Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	108-111	
31527329-6	2019	Moreover, cordycepin effectively inactivated the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, while LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of cordycepin.	cordycepin	10-20	AKT serine/threonine kinase 1	Homo sapiens	82-85	
31527329-6	2019	Moreover, cordycepin effectively inactivated the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, while LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of cordycepin.	cordycepin	10-20	AKT serine/threonine kinase 1	Homo sapiens	128-131	
31527329-7	2019	Cordycepin further enhanced the intracellular levels of reactive oxygen species (ROS), while the addition of N-acetyl cysteine (NAC), a ROS inhibitor, significantly diminished cordycepin-induced mitochondrial dysfunction and growth inhibition, and also blocked the inactivation of PI3K/Akt signaling pathway.	cordycepin	176-186	AKT serine/threonine kinase 1	Homo sapiens	286-289	
31527329-9	2019	Collectively, the data indicate that cordycepin induces apoptosis through the activation of extrinsic and intrinsic apoptosis pathways and the ROS-dependent inactivation of PI3K/Akt signaling in human bladder cancer T24 cells.	cordycepin	37-47	AKT serine/threonine kinase 1	Homo sapiens	178-181	
30336060-0	2018	Cordycepin Augments the Chemosensitivity of Human Glioma Cells to Temozolomide by Activating AMPK and Inhibiting the AKT Signaling Pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	117-120	
30336060-13	2018	Moreover, we also demonstrated that cordycepin effectively enhanced the activation of AMPK and suppressed the activity of AKT, whose activation was only induced by TMZ.	cordycepin	36-46	AKT serine/threonine kinase 1	Homo sapiens	122-125	
28912858-0	2017	Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	99-102	
29844932-0	2018	Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-kappaB signaling pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	87-90	
29844932-6	2018	In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.	cordycepin	50-60	AKT serine/threonine kinase 1	Homo sapiens	106-109	
29844932-6	2018	In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.	cordycepin	50-60	AKT serine/threonine kinase 1	Homo sapiens	179-182	
29844932-11	2018	Thus, these results indicate that cordycepin inhibits CCL5-mediated Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells, supporting the potential of cordycepin as a therapeutic agent for ovarian cancer.	cordycepin	34-44	AKT serine/threonine kinase 1	Homo sapiens	68-71	
28197639-0	2017	Cordycepin induces apoptosis in SGC-7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	103-106	
28714368-4	2017	Cordyceps militaris hot water extracts containing cordycepin was used to treat human T24 bladder carcinoma cells, and we found that Cordyceps militaris hot water extracts containing cordycepin decreased T24 cell survival in a dose-dependent manner, which was seemingly mediated by activation of A3 adenosine receptor and the subsequent inactivation of Akt pathways, resulting in increases in cleaved Caspase-3 and apoptosis.	cordycepin	50-60	AKT serine/threonine kinase 1	Homo sapiens	352-355	
28197639-4	2017	Cordycepin incorporates mitochondrial-mediated apoptosis in SGC-7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP).	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	224-227	
25282637-4	2015	Cordycepin also attenuated the activation of phosphoinositide-3-kinase (PI3K)/Akt signaling, thereby reducing phosphorylation and nuclear translocation of hTERT.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	78-81