PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	212-216	
22740928-9	2012	MLH1-deficient cells also exhibited reduced susceptibility to apoptosis upon treatment with cordycepin, as demonstrated by the reduced PARP-1 cleavage.	cordycepin	92-102	poly(ADP-ribose) polymerase 1	Homo sapiens	135-141	
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	183-210	
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	275-279	
21607289-8	2011	In a cell-free system, cordycepin inhibited PARP-1 activity at nanomolar concentrations.	cordycepin	23-33	poly(ADP-ribose) polymerase 1	Homo sapiens	44-50	
21607289-9	2011	Similar to PARP inhibitors, cordycepin significantly induced killing of breast cancer susceptibility gene (BRCA1)-deficient MCF-7 cells, supporting its therapeutic use for the treatment of BRCA-deficient breast cancers.	cordycepin	28-38	poly(ADP-ribose) polymerase 1	Homo sapiens	11-15	
21607289-11	2011	Cordycepin, to the best of our knowledge, represents the first natural product possessing PARP inhibitory traits.	cordycepin	0-10	poly(ADP-ribose) polymerase 1	Homo sapiens	90-94	
23543357-5	2014	In cellular mechanism study, co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase (JNK), the expressions of caspase-7, and the cleavage of poly ADP-ribose polymerase (PARP) as compared to cisplatin or cordycepin alone treatment (P <0.05).	cordycepin	45-55	poly(ADP-ribose) polymerase 1	Homo sapiens	192-218	
23543357-5	2014	In cellular mechanism study, co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase (JNK), the expressions of caspase-7, and the cleavage of poly ADP-ribose polymerase (PARP) as compared to cisplatin or cordycepin alone treatment (P <0.05).	cordycepin	45-55	poly(ADP-ribose) polymerase 1	Homo sapiens	220-224	
23543357-6	2014	CONCLUSION: Cisplatin and cordycepin possess synergistically apoptotic effect through the activation of JNK/caspase-7/PARP pathway in human OC3 oral cancer cell line.	cordycepin	26-36	poly(ADP-ribose) polymerase 1	Homo sapiens	118-122	
20961042-0	2010	Cordycepin induces apoptosis of CGTH W-2 thyroid carcinoma cells through the calcium-calpain-caspase 7-PARP pathway.	cordycepin	0-10	poly(ADP-ribose) polymerase 1	Homo sapiens	103-107