PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35525345-0	2022	Arsenic exposure elevated ROS promotes energy metabolic reprogramming with enhanced AKT-dependent HK2 expression.	Arsenic	0-7	hexokinase 2	Homo sapiens	98-101	
35525345-10	2022	Taken together, our results indicated that ROS induced by low-dose arsenic exposure determined energy metabolic reprogramming and acted a critical regulator for AKT-dependent HK2 expression and aerobic glycolysis.	Arsenic	67-74	hexokinase 2	Homo sapiens	175-178	
35525345-5	2022	Here, mtDNA copy number is enhanced in arsenic-exposed populations and a positive correlation between serum HK2 and urinary total arsenic was observed in the individuals with high urine arsenic (>= 0.032 mg/L).	Arsenic	39-46	hexokinase 2	Homo sapiens	108-111	
35525345-5	2022	Here, mtDNA copy number is enhanced in arsenic-exposed populations and a positive correlation between serum HK2 and urinary total arsenic was observed in the individuals with high urine arsenic (>= 0.032 mg/L).	Arsenic	130-137	hexokinase 2	Homo sapiens	108-111	
35525345-5	2022	Here, mtDNA copy number is enhanced in arsenic-exposed populations and a positive correlation between serum HK2 and urinary total arsenic was observed in the individuals with high urine arsenic (>= 0.032 mg/L).	Arsenic	186-193	hexokinase 2	Homo sapiens	108-111	
35525345-7	2022	Subsequently, in a low-dose arsenic exposure cell model we found that 0.2 mumol/L iAs3+ induced aerobic glycolysis to promote L-02 cells proliferation and inhibit apoptosis, in which HK2 played an important role.	Arsenic	28-35	hexokinase 2	Homo sapiens	183-186	
30191986-4	2019	It is in this context that the current study evaluated the effects of long-term arsenic exposure on the cellular response in morphology, and marker genes expression with respect to fibrosis using human kidney 2 (HK-2) epithelial cells.	Arsenic	80-87	hexokinase 2	Homo sapiens	212-216	
30191986-5	2019	Results of this study revealed that in addition to increased growth, HK-2 cells underwent phenotypic, biochemical and molecular changes indicative of epithelial-mesenchymal transition (EMT) in response to the exposure to arsenic.	Arsenic	221-228	hexokinase 2	Homo sapiens	69-73	
14686617-0	2003	Toxicity and metabolism of subcytotoxic inorganic arsenic in human renal proximal tubule epithelial cells (HK-2).	Arsenic	50-57	hexokinase 2	Homo sapiens	107-111	
14686617-3	2003	This study investigates the potential of an immortalized human proximal tubular epithelial cell line, HK-2, to serve as a representative model for low level exposures of the human kidney to arsenic.	Arsenic	190-197	hexokinase 2	Homo sapiens	102-106	
14686617-10	2003	When compared to the activities of these enzymes in other animal tissues, the specific activities of HK-2 cells were indicative of a robust capacity to metabolize arsenic.	Arsenic	163-170	hexokinase 2	Homo sapiens	101-105	
26598702-0	2015	Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.	Arsenic	29-36	hexokinase 2	Homo sapiens	67-79	
26598702-0	2015	Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.	Arsenic	96-103	hexokinase 2	Homo sapiens	67-79	
26598702-5	2015	Detailed biochemical and metabolomics analyses of the highly homologous hexokinase-2 (HK2), which is overexpressed in many cancers, revealed significant inhibition by arsenic.	Arsenic	167-174	hexokinase 2	Homo sapiens	72-84	
26598702-5	2015	Detailed biochemical and metabolomics analyses of the highly homologous hexokinase-2 (HK2), which is overexpressed in many cancers, revealed significant inhibition by arsenic.	Arsenic	167-174	hexokinase 2	Homo sapiens	86-89	
26598702-6	2015	Furthermore, overexpression of HK2 rescued cells from arsenic-induced apoptosis.	Arsenic	54-61	hexokinase 2	Homo sapiens	31-34	
26598702-7	2015	Our results thus strongly implicate glycolysis, and HK2 in particular, as a key target of arsenic.	Arsenic	90-97	hexokinase 2	Homo sapiens	52-55