PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22391311-5	2012	Recent evidence has shown that arsenic can inhibit the Hedgehog pathway by inhibiting GLI proteins.	Arsenic	31-38	GLI family zinc finger 1	Homo sapiens	86-89	
26573582-0	2016	Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner.	Arsenic	0-7	GLI family zinc finger 1	Homo sapiens	19-22	
20624968-3	2010	We report here that arsenicals, in contrast, antagonize the Hh pathway by targeting Gli transcriptional effectors; in the short term, arsenic blocks Hh-induced ciliary accumulation of Gli2, the primary activator of Hh-dependent transcription, and with prolonged incubation arsenic reduces steady-state levels of Gli2.	Arsenic	20-27	GLI family zinc finger 1	Homo sapiens	84-87	
26573582-5	2016	Here we provide in vitro and in vivo evidence that arsenic acts as a modulator of the activity of the HH effector protein glioma-associated oncogene family zinc finger (GLI), activating or inhibiting GLI activity in a context-dependent manner.	Arsenic	51-58	GLI family zinc finger 1	Homo sapiens	122-167	
26573582-5	2016	Here we provide in vitro and in vivo evidence that arsenic acts as a modulator of the activity of the HH effector protein glioma-associated oncogene family zinc finger (GLI), activating or inhibiting GLI activity in a context-dependent manner.	Arsenic	51-58	GLI family zinc finger 1	Homo sapiens	169-172	
26573582-5	2016	Here we provide in vitro and in vivo evidence that arsenic acts as a modulator of the activity of the HH effector protein glioma-associated oncogene family zinc finger (GLI), activating or inhibiting GLI activity in a context-dependent manner.	Arsenic	51-58	GLI family zinc finger 1	Homo sapiens	200-203	
26573582-7	2016	Our results show that arsenic activates GLI signaling when the intrinsic GLI activity is low but inhibits signaling in the presence of high-level GLI activity.	Arsenic	22-29	GLI family zinc finger 1	Homo sapiens	40-43	
26573582-7	2016	Our results show that arsenic activates GLI signaling when the intrinsic GLI activity is low but inhibits signaling in the presence of high-level GLI activity.	Arsenic	22-29	GLI family zinc finger 1	Homo sapiens	73-76	
26573582-7	2016	Our results show that arsenic activates GLI signaling when the intrinsic GLI activity is low but inhibits signaling in the presence of high-level GLI activity.	Arsenic	22-29	GLI family zinc finger 1	Homo sapiens	73-76	
26573582-9	2016	Combining our findings with previous reports, we present an inclusive model in which arsenic plays dual roles in GLI signaling modulation: when GLIs are primarily in their repressor form, arsenic antagonizes their repression capacity, leading to low-level GLI activation, but when GLIs are primarily in their activator form, arsenic attenuates their activity.	Arsenic	85-92	GLI family zinc finger 1	Homo sapiens	113-116	
26573582-9	2016	Combining our findings with previous reports, we present an inclusive model in which arsenic plays dual roles in GLI signaling modulation: when GLIs are primarily in their repressor form, arsenic antagonizes their repression capacity, leading to low-level GLI activation, but when GLIs are primarily in their activator form, arsenic attenuates their activity.	Arsenic	85-92	GLI family zinc finger 1	Homo sapiens	144-147	
26573582-9	2016	Combining our findings with previous reports, we present an inclusive model in which arsenic plays dual roles in GLI signaling modulation: when GLIs are primarily in their repressor form, arsenic antagonizes their repression capacity, leading to low-level GLI activation, but when GLIs are primarily in their activator form, arsenic attenuates their activity.	Arsenic	188-195	GLI family zinc finger 1	Homo sapiens	113-116	
25448440-10	2014	Moreover, additional extracellular SHH rescued the inhibitory effects of arsenic on cellular differentiation due to an increase in GLI binding activity.	Arsenic	73-80	GLI family zinc finger 1	Homo sapiens	131-134