PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34014776-2 2021 Different oxidation and methylation states of arsenic exist in the environment and are formed in vivo via the action of arsenic (+3 oxidation state) methyltransferase (As3MT). Arsenic 46-53 arsenite methyltransferase Mus musculus 120-166 34014776-2 2021 Different oxidation and methylation states of arsenic exist in the environment and are formed in vivo via the action of arsenic (+3 oxidation state) methyltransferase (As3MT). Arsenic 46-53 arsenite methyltransferase Mus musculus 168-173 32779937-0 2020 Arsenic Metabolism in Mice Carrying a BORCS7/AS3MT Locus Humanized by Syntenic Replacement. Arsenic 0-7 arsenite methyltransferase Mus musculus 45-50 28728140-1 2017 BACKGROUND: Arsenic is metabolized through a series of oxidative methylation reactions by arsenic (3) methyltransferase (As3MT) to yield methylated intermediates. Arsenic 12-19 arsenite methyltransferase Mus musculus 121-126 30575732-5 2018 Mice lacking the primary arsenic detoxification enzyme (As3mt) are hypersensitive to arsenic after antibiotic treatment or when derived germ-free, compared to wild-type and/or conventional counterparts. Arsenic 25-32 arsenite methyltransferase Mus musculus 56-61 30575732-5 2018 Mice lacking the primary arsenic detoxification enzyme (As3mt) are hypersensitive to arsenic after antibiotic treatment or when derived germ-free, compared to wild-type and/or conventional counterparts. Arsenic 85-92 arsenite methyltransferase Mus musculus 56-61 30575732-6 2018 Human microbiome (stool) transplants protect germ-free As3mt-KO mice from arsenic-induced mortality, but protection depends on microbiome stability and the presence of specific bacteria, including Faecalibacterium. Arsenic 74-81 arsenite methyltransferase Mus musculus 55-60 28728140-3 2017 OBJECTIVES: Our objective was to define whether methylated arsenic intermediates were proatherogenic and whether arsenic biotransformation by As3MT was required for arsenic-enhanced atherosclerosis. Arsenic 113-120 arsenite methyltransferase Mus musculus 142-147 28728140-3 2017 OBJECTIVES: Our objective was to define whether methylated arsenic intermediates were proatherogenic and whether arsenic biotransformation by As3MT was required for arsenic-enhanced atherosclerosis. Arsenic 113-120 arsenite methyltransferase Mus musculus 142-147 28728140-7 2017 Finally, bone marrow transplantation studies were performed to define the contribution of As3MT-mediated methylation in different cell types to the development of atherosclerosis after inorganic arsenic exposure. Arsenic 195-202 arsenite methyltransferase Mus musculus 90-95 21934131-1 2011 Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes methylation of inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Arsenic 90-97 arsenite methyltransferase Mus musculus 0-46 27591999-1 2016 Arsenic (+3 oxidation state) methyltransferase is the key enzyme in the methylation pathway for inorganic arsenic. Arsenic 106-113 arsenite methyltransferase Mus musculus 0-46 26446802-3 2016 mRNA for AS3mt, the gene responsible for methylation of arsenic, was detected in all embryonic tissue types studied. Arsenic 56-63 arsenite methyltransferase Mus musculus 9-14 22733250-1 2013 Arsenic (+3 oxidation state) methyltransferase (As3mt) plays a central role in the enzymatically catalyzed conversion of inorganic arsenic into methylated metabolites. Arsenic 131-138 arsenite methyltransferase Mus musculus 0-46 22733250-1 2013 Arsenic (+3 oxidation state) methyltransferase (As3mt) plays a central role in the enzymatically catalyzed conversion of inorganic arsenic into methylated metabolites. Arsenic 131-138 arsenite methyltransferase Mus musculus 48-53 22733250-4 2013 Here, we report on the presence of methylated oxy- and thioarsenicals in urine and liver from wild-type mice that efficiently methylate inorganic arsenic and from As3mt knockout mice that lack arsenic methyltransferase activity. Arsenic 59-66 arsenite methyltransferase Mus musculus 163-168 21934131-1 2011 Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes methylation of inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Arsenic 90-97 arsenite methyltransferase Mus musculus 48-53 19167370-5 2009 The metabolism of inorganic arsenic in human is different from rat and mouse in some aspects though the AS3MT has a high degree of similarity in these species. Arsenic 28-35 arsenite methyltransferase Mus musculus 104-109 21385732-1 2011 The enzyme arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes reactions converting inorganic arsenic to methylated metabolites, some of which are highly cytotoxic. Arsenic 11-18 arsenite methyltransferase Mus musculus 59-64 21385732-2 2011 In a previous study, female As3mt knockout (KO) mice treated with diet containing 100 or 150 ppm arsenic as arsenite showed systemic toxicity and significant effects on the urothelium. Arsenic 97-104 arsenite methyltransferase Mus musculus 28-33 20887743-0 2010 Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice. Arsenic 107-114 arsenite methyltransferase Mus musculus 0-46 20887743-1 2010 Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes formation of mono-, di-, and tri-methylated metabolites of inorganic arsenic. Arsenic 134-141 arsenite methyltransferase Mus musculus 0-46 20887743-1 2010 Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes formation of mono-, di-, and tri-methylated metabolites of inorganic arsenic. Arsenic 134-141 arsenite methyltransferase Mus musculus 48-53 20887743-4 2010 At steady state, arsenic body burdens in As3mt knockout mice were 16 to 20 times greater than in wild-type mice. Arsenic 17-24 arsenite methyltransferase Mus musculus 41-46 20887743-5 2010 During the post dosing clearance period, arsenic body burdens declined in As3mt knockout mice to ~35% and in wild-type mice to ~10% of steady-state levels. Arsenic 41-48 arsenite methyltransferase Mus musculus 74-79 20887743-6 2010 Urinary concentration of arsenic was significantly lower in As3mt knockout mice than in wild-type mice. Arsenic 25-32 arsenite methyltransferase Mus musculus 60-65 20887743-9 2010 Inorganic arsenic was the predominant species in tissues of As3mt knockout mice; tissues from wild-type mice contained mixtures of inorganic arsenic and its methylated metabolites. Arsenic 10-17 arsenite methyltransferase Mus musculus 60-65 20887743-10 2010 Diminished capacity for arsenic methylation in As3mt knockout mice prolongs retention of inorganic arsenic in tissues and affects whole body clearance of arsenic. Arsenic 24-31 arsenite methyltransferase Mus musculus 47-52 20887743-10 2010 Diminished capacity for arsenic methylation in As3mt knockout mice prolongs retention of inorganic arsenic in tissues and affects whole body clearance of arsenic. Arsenic 99-106 arsenite methyltransferase Mus musculus 47-52 20887743-10 2010 Diminished capacity for arsenic methylation in As3mt knockout mice prolongs retention of inorganic arsenic in tissues and affects whole body clearance of arsenic. Arsenic 99-106 arsenite methyltransferase Mus musculus 47-52 20887743-11 2010 Altered retention and tissue tropism of arsenic in As3mt knockout mice could affect the toxic or carcinogenic effects associated with exposure to this metalloid or its methylated metabolites. Arsenic 40-47 arsenite methyltransferase Mus musculus 51-56 20423714-2 2010 Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes reactions which convert inorganic arsenic to methylated metabolites. Arsenic 99-106 arsenite methyltransferase Mus musculus 0-46 20423714-2 2010 Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes reactions which convert inorganic arsenic to methylated metabolites. Arsenic 99-106 arsenite methyltransferase Mus musculus 48-53 20423714-3 2010 This study determined whether the As3mt null genotype in the mouse modifies cytotoxic and proliferative effects seen in urinary bladders of wild type mice after exposure to inorganic arsenic. Arsenic 183-190 arsenite methyltransferase Mus musculus 34-39 20423714-11 2010 Thus, diminished arsenic methylation in As3mt KO mice exacerbates systemic toxicity and the effects of As(III) on the bladder epithelium, showing that altered kinetic and dynamic behavior of arsenic can affect its toxicity. Arsenic 17-24 arsenite methyltransferase Mus musculus 40-45 20423714-11 2010 Thus, diminished arsenic methylation in As3mt KO mice exacerbates systemic toxicity and the effects of As(III) on the bladder epithelium, showing that altered kinetic and dynamic behavior of arsenic can affect its toxicity. Arsenic 191-198 arsenite methyltransferase Mus musculus 40-45 19691357-1 2009 The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein that catalyzes methylation of inorganic arsenic. Arsenic 4-11 arsenite methyltransferase Mus musculus 52-57 19691357-7 2009 At 2 and 24 h after dosing, livers of As3mt knockouts contained a greater proportion of inorganic and monomethylated arsenic than did livers of C57BL/6 mice. Arsenic 117-124 arsenite methyltransferase Mus musculus 38-43 19691357-8 2009 A similar predominance of inorganic and monomethylated arsenic was found in the urine of As3mt knockouts. Arsenic 55-62 arsenite methyltransferase Mus musculus 89-94 19691357-9 2009 At 24 h after dosing, As3mt knockouts retained significantly higher percentages of arsenic dose in liver, kidneys, urinary bladder, lungs, heart, and carcass than did C57BL/6 mice. Arsenic 83-90 arsenite methyltransferase Mus musculus 22-27 19691357-13 2009 These data confirm a central role for As3mt in the metabolism of inorganic arsenic and indicate that phenotypes for arsenic retention and distribution are markedly affected by the null genotype for arsenic methylation, indicating a close linkage between the metabolism and retention of arsenicals. Arsenic 75-82 arsenite methyltransferase Mus musculus 38-43 35244730-2 2022 In human and mouse, inorganic arsenic (iAs) is metabolized in a series of methylation steps catalyzed by arsenic (3) methyltransferase (AS3MT), forming methylated arsenite (MAsIII), dimethylarsenite (DMAIII) and the volatile trimethylarsine (TMA). Arsenic 30-37 arsenite methyltransferase Mus musculus 136-141 35244730-2 2022 In human and mouse, inorganic arsenic (iAs) is metabolized in a series of methylation steps catalyzed by arsenic (3) methyltransferase (AS3MT), forming methylated arsenite (MAsIII), dimethylarsenite (DMAIII) and the volatile trimethylarsine (TMA). Arsenic 105-112 arsenite methyltransferase Mus musculus 136-141 35244730-3 2022 The methylation of arsenic is coordinated by four conserved cysteines proposed to participate in catalysis, namely C33, C62, C157, and C207 in mouse AS3MT. Arsenic 19-26 arsenite methyltransferase Mus musculus 149-154