PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25563643-1 2015 BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Phosphorus 88-98 fibroblast growth factor 23 Homo sapiens 24-51 25563643-1 2015 BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Phosphorus 88-98 fibroblast growth factor 23 Homo sapiens 53-58 25563643-6 2015 RESULTS: In multivariable-adjusted models, higher calcium and phosphorus concentrations, lower estimated glomerular filtration rate and higher urine albumin excretion were independently associated with higher FGF23. Phosphorus 62-72 fibroblast growth factor 23 Homo sapiens 209-214 26287973-11 2015 CONCLUSIONS: Aberrant phosphorus homeostasis, reflected by higher phosphorus and FGF23, may be a risk factor for mortality in patients initiating hemodialysis, particularly among African Americans. Phosphorus 22-32 fibroblast growth factor 23 Homo sapiens 81-86 26288017-0 2015 Why Is the Association of Phosphorus and FGF23 with Mortality Stronger in African-American Hemodialysis Patients. Phosphorus 26-36 fibroblast growth factor 23 Homo sapiens 41-46 26693712-1 2015 BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. Phosphorus 107-117 fibroblast growth factor 23 Homo sapiens 12-39 26693712-1 2015 BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. Phosphorus 107-117 fibroblast growth factor 23 Homo sapiens 41-46 24578219-0 2014 Dietary phosphorus restriction by a standard low-protein diet decreased serum fibroblast growth factor 23 levels in patients with early and advanced stage chronic kidney disease. Phosphorus 8-18 fibroblast growth factor 23 Homo sapiens 78-105 24578219-2 2014 Although recent studies demonstrated that FGF23 levels decreased in response to dietary restriction of phosphorus and/or use of phosphate binders, research on the effects of a standard low-protein diet is lacking. Phosphorus 103-113 fibroblast growth factor 23 Homo sapiens 42-47 24578219-5 2014 Changes in FGF23 levels correlated with changes in 24 h urinary phosphorus excretion in the advanced CKD group. Phosphorus 64-74 fibroblast growth factor 23 Homo sapiens 11-16 25132581-9 2014 Univariate analysis showed significant correlations of serum phosphorus with TMP/GFR, alkaline phosphatase, age, lactate dehydrogenase (LDH), and log intact FGF23. Phosphorus 61-71 fibroblast growth factor 23 Homo sapiens 157-162 25132581-12 2014 CONCLUSION: The elevated serum phosphorus concentrations with simultaneously increased TMP/GFR and elevated FGF23 levels collectively suggest that patients with SCD display proximal tubular resistance to the action of FGF23 before any decline in GFR. Phosphorus 31-41 fibroblast growth factor 23 Homo sapiens 218-223 25878777-10 2014 The log-FGF23 strongly correlated with calcium levels at Months 1, 6 and 12, however, this relationship was blunted if serum phosphorus was >6 mg/dL. Phosphorus 125-135 fibroblast growth factor 23 Homo sapiens 8-13 23647316-10 2014 FGF23 increased 50% with a positive correlation with the indexes of metabolic effort and, consequently, phosphorous decreased, although only in the first half. Phosphorus 104-115 fibroblast growth factor 23 Homo sapiens 0-5 24674095-1 2014 Fibroblast growth factor 23 (FGF23) levels in dialysis patients are influenced by various factors, including phosphorus load. Phosphorus 109-119 fibroblast growth factor 23 Homo sapiens 0-27 24674095-1 2014 Fibroblast growth factor 23 (FGF23) levels in dialysis patients are influenced by various factors, including phosphorus load. Phosphorus 109-119 fibroblast growth factor 23 Homo sapiens 29-34 24601885-2 2014 Although these actions are well established in adults and children, the role that FGF23 plays in regulating fetal phosphorus metabolism has not been previously studied. Phosphorus 114-124 fibroblast growth factor 23 Homo sapiens 82-87 24216259-2 2014 From a physiological perspective and supported by some data, phosphorus is the main driver for FGF-23 secretion. Phosphorus 61-71 fibroblast growth factor 23 Homo sapiens 95-101 24216259-3 2014 Therefore, it is conceivable that interventions aiming at restriction of phosphorus uptake from the gastrointestinal tract may lower serum FGF-23 levels and improve cardiovascular risk and subsequently survival. Phosphorus 73-83 fibroblast growth factor 23 Homo sapiens 139-145 24045674-1 2014 OBJECTIVE: GALNT3 gene encodes the glycosyltransferase polypeptide N-acetylgalactosaminyltransferase-3 (ppGalNacT3), which initiates the O-glycosylation of fibroblast growth factor 23 (FGF23) that is important in phosphorous regulation. Phosphorus 213-224 fibroblast growth factor 23 Homo sapiens 156-183 24045674-1 2014 OBJECTIVE: GALNT3 gene encodes the glycosyltransferase polypeptide N-acetylgalactosaminyltransferase-3 (ppGalNacT3), which initiates the O-glycosylation of fibroblast growth factor 23 (FGF23) that is important in phosphorous regulation. Phosphorus 213-224 fibroblast growth factor 23 Homo sapiens 185-190 24669256-2 2014 In addition, the correlation between serum FGF-23 and phosphorus (Pi) levels and the clinical implications were identified. Phosphorus 54-64 fibroblast growth factor 23 Homo sapiens 43-49 24550322-4 2014 Therapy aims at counteracting consequences of FGF23 excess, i.e. oral phosphorus supplementation with multiple daily intakes to compensate for renal phosphate wasting and active vitamin D analogs (alfacalcidol or calcitriol) to counter the 1,25-diOH-vitamin D deficiency. Phosphorus 70-80 fibroblast growth factor 23 Homo sapiens 46-51 24311704-9 2014 Serum phosphorus levels, adjusted for age, were significantly lower at GFR of 60-69 ml/min per 1.73 m(2) than higher GFR, but thereafter they became higher in parallel with fibroblast growth factor 23 as GFR declined. Phosphorus 6-16 fibroblast growth factor 23 Homo sapiens 173-200 24009282-7 2014 While serum phosphorus levels correlated with FGF23 concentrations in each group separately [r=0.522 (P<0.01) and r=0.42 (P<0.01) in short daily and conventional in-center hemodialysis, respectively], FGF23 levels were lower [823 RU/mL (263, 2169)] in the patients receiving short daily hemodialysis than in patients treated with conventional hemodialysis [2521 RU/mL (909, 5556)] (P<0.01 between groups). Phosphorus 12-22 fibroblast growth factor 23 Homo sapiens 46-51 24009282-7 2014 While serum phosphorus levels correlated with FGF23 concentrations in each group separately [r=0.522 (P<0.01) and r=0.42 (P<0.01) in short daily and conventional in-center hemodialysis, respectively], FGF23 levels were lower [823 RU/mL (263, 2169)] in the patients receiving short daily hemodialysis than in patients treated with conventional hemodialysis [2521 RU/mL (909, 5556)] (P<0.01 between groups). Phosphorus 12-22 fibroblast growth factor 23 Homo sapiens 207-212 24425727-8 2014 In our loading test with a low-calcium, high-phosphorus lunch provided to healthy young men, serum PTH concentrations showed peaks at 1 and 6 h, and serum fibroblast growth factor 23 (FGF23) concentrations increased significantly at 8 h after the meal. Phosphorus 45-55 fibroblast growth factor 23 Homo sapiens 184-189 24425727-9 2014 In contrast, the high-calcium, high-phosphorus meal suppressed the second PTH and FGF23 elevations until 8 h after the meal. Phosphorus 36-46 fibroblast growth factor 23 Homo sapiens 82-87 24425727-10 2014 This implies that adequate dietary calcium intake is needed to overcome the interfering effects of high phosphorus intake on PTH and FGF23 secretion. Phosphorus 104-114 fibroblast growth factor 23 Homo sapiens 133-138 24425727-13 2014 These findings suggest that long-term high-phosphorus diets may impair bone health mediated by FGF23 resistance both in chronic kidney disease patients and in the healthy population. Phosphorus 43-53 fibroblast growth factor 23 Homo sapiens 95-100 24854458-7 2014 A significant decline from baseline (10.9%, p < 0.01) in the serum FGF23 concentration was observed in the ERN group compared to placebo, but not in the ERN-L group compared to placebo (p = 0.36 and 0.97 for ERN-L and placebo, respectively), despite equivalent declines in serum phosphorus. Phosphorus 282-292 fibroblast growth factor 23 Homo sapiens 70-75 25088267-4 2014 Calciotropic hormones such as vitamin D and parathyroid hormone, as well as hormones controlling phosphorus homeostasis, such as fibroblast growth factor-23 (FGF-23), are essential in controlling these interactions. Phosphorus 97-107 fibroblast growth factor 23 Homo sapiens 129-156 25088267-4 2014 Calciotropic hormones such as vitamin D and parathyroid hormone, as well as hormones controlling phosphorus homeostasis, such as fibroblast growth factor-23 (FGF-23), are essential in controlling these interactions. Phosphorus 97-107 fibroblast growth factor 23 Homo sapiens 158-164 24164913-10 2014 Younger age, lower prevalence of diabetes, longer dialysis vintage, and higher calcium and phosphorus were independently associated with higher FGF-23 levels. Phosphorus 91-101 fibroblast growth factor 23 Homo sapiens 144-150 23296792-1 2014 Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis. Phosphorus 85-95 fibroblast growth factor 23 Homo sapiens 0-27 23296792-1 2014 Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis. Phosphorus 85-95 fibroblast growth factor 23 Homo sapiens 29-35 24975224-8 2014 Furthermore, rats treated with cinacalcet+human PTH (1-34) showed transiently but significantly higher plasma FGF23 levels at 3 h after oral phosphorus administration compared with cinacalcet-treated rats. Phosphorus 141-151 fibroblast growth factor 23 Homo sapiens 110-115 24864466-6 2014 In patients with different stages of CKD, the increase in FGF-23 levels, as glomerular filtration rate reduced, outstripped that in the serum levels of phosphorus and intact parathyroid hormone. Phosphorus 152-162 fibroblast growth factor 23 Homo sapiens 58-64 25019032-1 2013 The combination of serum 25-hydroxyvitamin D (25D) and fibroblast growth factor 23 (FGF23) levels predict hard renal outcomes in patients with chronic kidney disease (CKD), independent of classical markers of mineral and bone disorders, including serum phosphorus, parathyroid hormone, 1,25-dihydroxyvitamin D levels, and active vitamin D therapy. Phosphorus 253-263 fibroblast growth factor 23 Homo sapiens 84-89 24228204-4 2013 Fibroblast growth factor 23 and Klotho are novel mediators of phosphorus metabolism that are tightly linked to dietary phosphorus intake and show promise as integrated biomarkers of phosphorus excess and its long-term health consequences. Phosphorus 62-72 fibroblast growth factor 23 Homo sapiens 0-27 24228204-4 2013 Fibroblast growth factor 23 and Klotho are novel mediators of phosphorus metabolism that are tightly linked to dietary phosphorus intake and show promise as integrated biomarkers of phosphorus excess and its long-term health consequences. Phosphorus 119-129 fibroblast growth factor 23 Homo sapiens 0-27 24348506-8 2013 RESULTS: FGF-23 was elevated (mean: 4,681 pg/ml, SD: 3,906) and correlated with hsCRP, esRAGE, AOPP, dialysis vintage and phosphorus in univariate analysis. Phosphorus 122-132 fibroblast growth factor 23 Homo sapiens 9-15 24348506-9 2013 In multiple regression analysis, hsCRP, AOPP and phosphorus but not esRAGE were all significantly correlated to FGF-23 (R2 = 0.7, p < 0.001). Phosphorus 49-59 fibroblast growth factor 23 Homo sapiens 112-118 23877588-6 2013 A prolonged oral phosphorus load increases FGF-23 expression by a mechanism that includes local changes in the ratio of inorganic phosphate to pyrophosphate in bone. Phosphorus 17-27 fibroblast growth factor 23 Homo sapiens 43-49 23852336-4 2013 RESULTS: Circulating phosphate concentrations declined more rapidly and the fractional excretion of phosphorus was higher in the first week post-transplantation in subjects with higher FGF23 values. Phosphorus 100-110 fibroblast growth factor 23 Homo sapiens 185-190 24038251-5 2013 One of the hormonal factors acutely affected by dietary phosphorus loading is fibroblast growth factor-23, which may be a key factor responsible for many of the cardiovascular disease (CVD) complications of high phosphorus intake. Phosphorus 56-66 fibroblast growth factor 23 Homo sapiens 78-105 24038251-5 2013 One of the hormonal factors acutely affected by dietary phosphorus loading is fibroblast growth factor-23, which may be a key factor responsible for many of the cardiovascular disease (CVD) complications of high phosphorus intake. Phosphorus 212-222 fibroblast growth factor 23 Homo sapiens 78-105 23719553-5 2013 Although phosphorus is an essential nutrient, in excess it could be linked to tissue damage by a variety of mechanisms involved in the endocrine regulation of extracellular phosphate, specifically the secretion and action of fibroblast growth factor 23 and parathyroid hormone. Phosphorus 9-19 fibroblast growth factor 23 Homo sapiens 225-252 23961477-5 2013 The parathyroid hormone, vitamin D, Fibrogenic growth factor 23 (FGF23) and klotho coreceptor are the key regulators of phosphorus balance in body. Phosphorus 120-130 fibroblast growth factor 23 Homo sapiens 36-63 23961477-5 2013 The parathyroid hormone, vitamin D, Fibrogenic growth factor 23 (FGF23) and klotho coreceptor are the key regulators of phosphorus balance in body. Phosphorus 120-130 fibroblast growth factor 23 Homo sapiens 65-70 23532406-3 2013 FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal renal tubule cells. Phosphorus 22-32 fibroblast growth factor 23 Homo sapiens 0-5 23521343-3 2013 EXPERT OPINION: The initial event in the pathogenesis of secondary hyperparathyroidism is the phosphorus overload per nephron that lead to the secretion of a new phosphaturic hormone, fibroblast growth factor 23 from the bone. Phosphorus 94-104 fibroblast growth factor 23 Homo sapiens 184-211 23611556-2 2013 Through independent and combined effects on renal phosphorus and vitamin D metabolism, alterations in FGF23 and Klotho expression are essential for maintaining mineral homeostasis in kidney disease. Phosphorus 50-60 fibroblast growth factor 23 Homo sapiens 102-107 23520205-0 2013 Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomes. Phosphorus 24-34 fibroblast growth factor 23 Homo sapiens 68-95 23464730-4 2013 Fibroblast growth factor-23 is now considered to be a key regulator of plasma phosphorus concentration in people but has only recently been investigated in companion animal species. Phosphorus 78-88 fibroblast growth factor 23 Homo sapiens 0-27 23413976-12 2013 The relationship between FGF-23 and Ca*P for the older group could be expressed by the exponential model FGF-23= 38.15 e0.4625Ca*P. CONCLUSION: Abnormal values of FGF-23 in adolescents and young adults with CKD correlate with Ca* P in the absence of vascular calcifications, and may serve as a biomarker for the risk of cardiovascular calcifications. Phosphorus 39-40 fibroblast growth factor 23 Homo sapiens 25-31 23413976-12 2013 The relationship between FGF-23 and Ca*P for the older group could be expressed by the exponential model FGF-23= 38.15 e0.4625Ca*P. CONCLUSION: Abnormal values of FGF-23 in adolescents and young adults with CKD correlate with Ca* P in the absence of vascular calcifications, and may serve as a biomarker for the risk of cardiovascular calcifications. Phosphorus 39-40 fibroblast growth factor 23 Homo sapiens 105-111 23413976-12 2013 The relationship between FGF-23 and Ca*P for the older group could be expressed by the exponential model FGF-23= 38.15 e0.4625Ca*P. CONCLUSION: Abnormal values of FGF-23 in adolescents and young adults with CKD correlate with Ca* P in the absence of vascular calcifications, and may serve as a biomarker for the risk of cardiovascular calcifications. Phosphorus 39-40 fibroblast growth factor 23 Homo sapiens 105-111 22959760-1 2013 Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23). Phosphorus 118-128 fibroblast growth factor 23 Homo sapiens 187-214 22959760-1 2013 Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23). Phosphorus 118-128 fibroblast growth factor 23 Homo sapiens 216-222 23748218-4 2013 FGF-23, the humoral factor involved in phosphate metabolism, is strongly associated with serum phosphorus level. Phosphorus 95-105 fibroblast growth factor 23 Homo sapiens 0-6 23774446-2 2013 Studies in individuals without CKD suggest that FGF23 levels are regulated by dietary phosphorus; however, the effect of pharmacologic phosphorus restriction on FGF23 in CKD patients is uncertain. Phosphorus 86-96 fibroblast growth factor 23 Homo sapiens 48-53 23866594-1 2013 AIM: To study the clinical significance of determining the serum concentration of phosphorus and calcium metabolism regulators--the morphogenetic proteins FGF-23 and Klotho in patients with different stages of chronic kidney disease (CKD). Phosphorus 82-92 fibroblast growth factor 23 Homo sapiens 155-161 22997345-1 2012 BACKGROUND AND OBJECTIVE: Fibroblast growth factor 23 (FGF-23), a regulator of phosphorus metabolism, is a risk marker in CKD. Phosphorus 79-89 fibroblast growth factor 23 Homo sapiens 26-53 22997345-1 2012 BACKGROUND AND OBJECTIVE: Fibroblast growth factor 23 (FGF-23), a regulator of phosphorus metabolism, is a risk marker in CKD. Phosphorus 79-89 fibroblast growth factor 23 Homo sapiens 55-61 23146451-0 2012 Role of fibroblast growth factor 23 (FGF23) in the metabolism of phosphorus and calcium immediately after kidney transplantation. Phosphorus 65-75 fibroblast growth factor 23 Homo sapiens 8-35 23146451-0 2012 Role of fibroblast growth factor 23 (FGF23) in the metabolism of phosphorus and calcium immediately after kidney transplantation. Phosphorus 65-75 fibroblast growth factor 23 Homo sapiens 37-42 23146451-9 2012 CONCLUSIONS: Elevated serum levels of FGF23 could explain the deficiency of calcitriol and elevated renal phosphorus wasting in the early posttransplant period. Phosphorus 106-116 fibroblast growth factor 23 Homo sapiens 38-43 22703926-13 2012 CONCLUSIONS: FGF-23, a hormone involved in phosphorous and vitamin D homeostasis, is independently associated with all-cause death and incident HF in community-living older persons. Phosphorus 43-54 fibroblast growth factor 23 Homo sapiens 13-19 22311343-4 2012 RESULTS: In bivariate analyses, C-terminal FGF23 levels were positively related to phosphorus and uric acid levels. Phosphorus 83-93 fibroblast growth factor 23 Homo sapiens 43-48 23214203-5 2012 High phosphorus intake, 1,25-dihydroxyvitamin D3 and PTH are the main stimuli for FGF-23 secretion. Phosphorus 5-15 fibroblast growth factor 23 Homo sapiens 82-88 22025115-8 2012 RRF, serum phosphorus and calcium levels and active vitamin D therapy explain 69% of the variation in FGF-23. Phosphorus 11-21 fibroblast growth factor 23 Homo sapiens 102-108 22362063-2 2012 The aim of this pilot study is to assess whether a very-low-protein diet (0.3 g/kg per day) with a consequent low intake of phosphorus would reduce fibroblast growth factor 23 compared with a low-protein diet (0.6 g/kg per day) in CKD patients not yet on dialysis. Phosphorus 124-134 fibroblast growth factor 23 Homo sapiens 148-175 21825304-11 2012 Phosphorus overload was associated with higher serum FGF-23 levels and Runx-2, as well as myocardial hypertrophy. Phosphorus 0-10 fibroblast growth factor 23 Homo sapiens 53-59 22360923-0 2012 FGF23/Klotho axis: phosphorus, mineral metabolism and beyond. Phosphorus 19-29 fibroblast growth factor 23 Homo sapiens 0-5 21730210-7 2012 In multivariate regression analyses, changes from baseline in serum FGF23 were associated with changes in serum calcium and phosphorus but not with intact PTH at each time point of measurements (Week-12, Week-24 and Week-52). Phosphorus 124-134 fibroblast growth factor 23 Homo sapiens 68-73 22396166-3 2012 Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Phosphorus 46-56 fibroblast growth factor 23 Homo sapiens 0-27 22396166-3 2012 Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Phosphorus 46-56 fibroblast growth factor 23 Homo sapiens 29-34 22246283-1 2012 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Phosphorus 73-83 fibroblast growth factor 23 Homo sapiens 27-54 22246283-1 2012 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Phosphorus 73-83 fibroblast growth factor 23 Homo sapiens 56-61 22099949-5 2012 Independent predictors (estimate standard error) of log-transformed FGF-23 concentrations included phosphorus (0.75 [0.237], P = 0.002) and cardiac troponin T (1.04 [0.41], P = 0.01). Phosphorus 99-109 fibroblast growth factor 23 Homo sapiens 68-74 22701173-2 2012 Decreased glomerular filtration of phosphorus is initially compensated by decreased tubular reabsorption, regulated by PTH and FGF23, maintaining normal serum phosphorus concentrations. Phosphorus 35-45 fibroblast growth factor 23 Homo sapiens 127-132 22701173-8 2012 Phosphorus binders lower serum phosphorus and also FGF23 levels, without decreasing diet protein content. Phosphorus 0-10 fibroblast growth factor 23 Homo sapiens 51-56 22034506-1 2011 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Phosphorus 73-83 fibroblast growth factor 23 Homo sapiens 27-54 22034506-1 2011 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Phosphorus 73-83 fibroblast growth factor 23 Homo sapiens 56-61 22034506-4 2011 RESULTS: In multivariable-adjusted analyses, each 5-year increase in age was associated with 2.1 RU/ml higher FGF23, each 500-mg increase in phosphorus intake was associated with 3.4 RU/ml higher FGF23, and each 0.1-mg/dl increase in creatinine was associated with 3.4 RU/ml higher FGF23. Phosphorus 141-151 fibroblast growth factor 23 Homo sapiens 196-201 22034506-4 2011 RESULTS: In multivariable-adjusted analyses, each 5-year increase in age was associated with 2.1 RU/ml higher FGF23, each 500-mg increase in phosphorus intake was associated with 3.4 RU/ml higher FGF23, and each 0.1-mg/dl increase in creatinine was associated with 3.4 RU/ml higher FGF23. Phosphorus 141-151 fibroblast growth factor 23 Homo sapiens 196-201 22034506-8 2011 CONCLUSIONS: In community-dwelling adults with largely preserved kidney function, established cardiovascular risk factors and higher phosphorus intake were associated with higher FGF23. Phosphorus 133-143 fibroblast growth factor 23 Homo sapiens 179-184 21855188-2 2011 Fibroblast growth factor 23 (FGF-23) is a hormone originating from bone that regulates urine phosphorus excretion. Phosphorus 93-103 fibroblast growth factor 23 Homo sapiens 0-27 21855188-2 2011 Fibroblast growth factor 23 (FGF-23) is a hormone originating from bone that regulates urine phosphorus excretion. Phosphorus 93-103 fibroblast growth factor 23 Homo sapiens 29-35 21855188-14 2011 In the context of prior literature, these data suggest that postmenopausal phosphorus retention may stimulate higher FGF-23 concentrations after menopause. Phosphorus 75-85 fibroblast growth factor 23 Homo sapiens 117-123 21519253-4 2011 RECENT FINDINGS: Higher levels of serum phosphorus (including those within the normal range) and its regulatory hormone, fibroblast growth factor 23 (FGF-23), are associated with increased mortality in patients with all stages of CKD. Phosphorus 40-50 fibroblast growth factor 23 Homo sapiens 121-148 21519253-4 2011 RECENT FINDINGS: Higher levels of serum phosphorus (including those within the normal range) and its regulatory hormone, fibroblast growth factor 23 (FGF-23), are associated with increased mortality in patients with all stages of CKD. Phosphorus 40-50 fibroblast growth factor 23 Homo sapiens 150-156 20146335-2 2011 Fibroblast growth factor 23 (FGF-23) mRNA is overexpressed in the tumor tissue, leading to impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia. Phosphorus 116-126 fibroblast growth factor 23 Homo sapiens 0-27 20146335-2 2011 Fibroblast growth factor 23 (FGF-23) mRNA is overexpressed in the tumor tissue, leading to impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia. Phosphorus 116-126 fibroblast growth factor 23 Homo sapiens 29-35 21389978-1 2011 Fibroblast growth factor 23 (FGF23) regulates phosphorus metabolism and is a strong predictor of mortality in dialysis patients. Phosphorus 46-56 fibroblast growth factor 23 Homo sapiens 0-27 21389978-1 2011 Fibroblast growth factor 23 (FGF23) regulates phosphorus metabolism and is a strong predictor of mortality in dialysis patients. Phosphorus 46-56 fibroblast growth factor 23 Homo sapiens 29-34 21731867-12 2011 Both PTH and FGF23 were positively correlated with phosphorus and negatively with hemoglobin levels. Phosphorus 51-61 fibroblast growth factor 23 Homo sapiens 13-18 20813767-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphorus-regulating substance. Phosphorus 54-64 fibroblast growth factor 23 Homo sapiens 12-39 20813767-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphorus-regulating substance. Phosphorus 54-64 fibroblast growth factor 23 Homo sapiens 41-47 21406294-7 2011 Phosphorus stimulates FGF-23 secretion by osteocytes and expression of the osteoblastic transcriptome, thereby increasing extracellular matrix mineralization in atherosclerotic plaques, hypertrophic cartilage, and skeletal osteoblast surfaces. Phosphorus 0-10 fibroblast growth factor 23 Homo sapiens 22-28 21292848-9 2011 Directly treating phosphorus may be the most beneficial approach because this can reduce serum phosphorus, PTH, and FGF-23. Phosphorus 18-28 fibroblast growth factor 23 Homo sapiens 116-122 20631407-0 2011 Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease. Phosphorus 23-33 fibroblast growth factor 23 Homo sapiens 79-106 20631407-0 2011 Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease. Phosphorus 50-60 fibroblast growth factor 23 Homo sapiens 79-106 20631407-2 2011 Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD. Phosphorus 17-27 fibroblast growth factor 23 Homo sapiens 42-47 20946192-2 2011 Although previously considered to be caused by tertiary hyperparathyroidism, recent evidence suggests a primary role for persistently elevated circulating levels of the phosphorus-regulating hormone, FGF23. Phosphorus 169-179 fibroblast growth factor 23 Homo sapiens 200-205 21135546-10 2011 CONCLUSION: We confirmed the high prevalence of LVH in nondialyzed CKD patients and showed that FGF23, an early marker of phosphorus load, was an important factor associated with LVH in these patients. Phosphorus 122-132 fibroblast growth factor 23 Homo sapiens 96-101 21865755-4 2011 This review summarizes the role of the FGF-23 axis on phosphorus metabolism, and presents the clinical entities that arise from activation or inactivation of the FGF-23 axis. Phosphorus 54-64 fibroblast growth factor 23 Homo sapiens 39-45 22145450-1 2011 BACKGROUND: Children with growth hormone deficiency (GHD) have increased renal phosphorus reabsorption during rhGH therapy, Fibroblast growth factor 23 (FGF23) is a known regulator of serum phosphorus and may be responsible for this effect. Phosphorus 79-89 fibroblast growth factor 23 Homo sapiens 124-151 22145450-1 2011 BACKGROUND: Children with growth hormone deficiency (GHD) have increased renal phosphorus reabsorption during rhGH therapy, Fibroblast growth factor 23 (FGF23) is a known regulator of serum phosphorus and may be responsible for this effect. Phosphorus 79-89 fibroblast growth factor 23 Homo sapiens 153-158 22145450-1 2011 BACKGROUND: Children with growth hormone deficiency (GHD) have increased renal phosphorus reabsorption during rhGH therapy, Fibroblast growth factor 23 (FGF23) is a known regulator of serum phosphorus and may be responsible for this effect. Phosphorus 190-200 fibroblast growth factor 23 Homo sapiens 124-151 22145450-1 2011 BACKGROUND: Children with growth hormone deficiency (GHD) have increased renal phosphorus reabsorption during rhGH therapy, Fibroblast growth factor 23 (FGF23) is a known regulator of serum phosphorus and may be responsible for this effect. Phosphorus 190-200 fibroblast growth factor 23 Homo sapiens 153-158 22145450-7 2011 The C-FGF23 rise persisted after adjusting for age, gender, sex, total calcium, and phosphorus (p < 0.01) but attenuated after adjusting for TmP/GFR or IGF-1. Phosphorus 84-94 fibroblast growth factor 23 Homo sapiens 6-11 21959717-2 2011 Recently, new factors such as FGF-23 have been added to the classic list of regulators of bone metabolism, which include calcium, phosphorus, PTH and calcitriol. Phosphorus 130-140 fibroblast growth factor 23 Homo sapiens 30-36 20707671-1 2010 UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism. Phosphorus 160-170 fibroblast growth factor 23 Homo sapiens 33-60 20707671-1 2010 UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism. Phosphorus 160-170 fibroblast growth factor 23 Homo sapiens 62-68 20507957-3 2010 The primary systemic stimuli of FGF23 secretion are increased 1,25(OH)(2)D levels and increased dietary phosphorus intake. Phosphorus 104-114 fibroblast growth factor 23 Homo sapiens 32-37 20507957-4 2010 In kidney failure, FGF23 levels increase early and steadily rise with progression of kidney disease, likely as an appropriate physiologic adaptation to maintain normal phosphorus balance by helping to augment urinary phosphate excretion in conjunction with increased parathyroid hormone levels and by decreasing gut phosphorus absorption through decreased 1,25(OH)(2)D. In the long term, this compensation may become maladaptive by causing a progressive decline in 1,25(OH)(2)D levels with attendant consequences such as secondary hyperparathyroidism. Phosphorus 168-178 fibroblast growth factor 23 Homo sapiens 19-24 20507957-4 2010 In kidney failure, FGF23 levels increase early and steadily rise with progression of kidney disease, likely as an appropriate physiologic adaptation to maintain normal phosphorus balance by helping to augment urinary phosphate excretion in conjunction with increased parathyroid hormone levels and by decreasing gut phosphorus absorption through decreased 1,25(OH)(2)D. In the long term, this compensation may become maladaptive by causing a progressive decline in 1,25(OH)(2)D levels with attendant consequences such as secondary hyperparathyroidism. Phosphorus 316-326 fibroblast growth factor 23 Homo sapiens 19-24 20507943-2 2010 Excessive production of FGF23 by osteocytes is an appropriate compensation to help maintain normal phosphorus metabolism in these patients. Phosphorus 99-109 fibroblast growth factor 23 Homo sapiens 24-29 20507943-3 2010 Beginning in early CKD, progressive increases in levels of FGF23 enhance phosphaturia on a per-nephron basis and inhibit calcitriol production, thereby contributing centrally to the predominant phosphorus phenotype of predialysis kidney disease: normal serum phosphate, increased fractional excretion of phosphate, and calcitriol deficiency. Phosphorus 194-204 fibroblast growth factor 23 Homo sapiens 59-64 20571400-5 2010 In-vivo and in-vitro experiments demonstrated that FGF23 positively correlated, also in a dose-dependent manner, with the dose of estrogens and with the observed changes in calcitriol and phosphorus. Phosphorus 188-198 fibroblast growth factor 23 Homo sapiens 51-56 20583336-6 2010 Emerging data highlight the potential of FGF23 as a novel diagnostic to identify CKD patients at the highest risk for disease progression, cardiovascular disease, and death, and those who might benefit from early phosphorus-related therapies before the onset of overt hyperphosphatemia. Phosphorus 213-223 fibroblast growth factor 23 Homo sapiens 41-46 20558539-9 2010 Three loci were near genes encoding the kidney-specific type IIa sodium phosphate co-transporter (SLC34A1), the calcium-sensing receptor (CASR), and fibroblast growth factor 23 (FGF23), proteins that contribute to phosphorus metabolism. Phosphorus 214-224 fibroblast growth factor 23 Homo sapiens 149-176 20558539-9 2010 Three loci were near genes encoding the kidney-specific type IIa sodium phosphate co-transporter (SLC34A1), the calcium-sensing receptor (CASR), and fibroblast growth factor 23 (FGF23), proteins that contribute to phosphorus metabolism. Phosphorus 214-224 fibroblast growth factor 23 Homo sapiens 178-183 20628536-1 2010 The mechanism of FGF23 action in calcium/phosphorus metabolism of patients with chronic kidney disease (CKD) was studied using a mathematical model and clinical data in a public domain. Phosphorus 41-51 fibroblast growth factor 23 Homo sapiens 17-22 20628536-4 2010 Using the parameters identified from available clinical data, we observed that a transient decrease in the FGF23 level elevated the serum concentrations of PTH, calcitriol, and phosphorus. Phosphorus 177-187 fibroblast growth factor 23 Homo sapiens 107-112 20628536-6 2010 This model-based prediction indicated that the therapeutic reduction of FGF23 by the neutralizing antibody did not reduce phosphorus burden of CKD patients and decreased the urinary phosphorous excretion. Phosphorus 182-193 fibroblast growth factor 23 Homo sapiens 72-77 20628536-7 2010 Thus, the high FGF23 level in CKD patients was predicted to be a failure of FGF23-mediated phosphorous excretion. Phosphorus 91-102 fibroblast growth factor 23 Homo sapiens 15-20 20628536-7 2010 Thus, the high FGF23 level in CKD patients was predicted to be a failure of FGF23-mediated phosphorous excretion. Phosphorus 91-102 fibroblast growth factor 23 Homo sapiens 76-81 20012997-1 2010 Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD). Phosphorus 105-115 fibroblast growth factor 23 Homo sapiens 48-75 20012997-1 2010 Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD). Phosphorus 105-115 fibroblast growth factor 23 Homo sapiens 77-83 20059333-2 2010 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels. Phosphorus 195-205 fibroblast growth factor 23 Homo sapiens 0-27 20059333-2 2010 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels. Phosphorus 195-205 fibroblast growth factor 23 Homo sapiens 29-34 20059333-3 2010 Synthesis and secretion of FGF23 by osteocytes are positively regulated by 1,25(OH)(2)D and serum phosphorus and negatively regulated, through yet unknown mechanisms, by the phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and by dentin matrix protein 1 (DMP1). Phosphorus 98-108 fibroblast growth factor 23 Homo sapiens 27-32 19770756-2 2009 RECENT FINDINGS: FGF23 regulates phosphorus and vitamin D metabolism. Phosphorus 33-43 fibroblast growth factor 23 Homo sapiens 17-22 19615558-1 2009 The calcium sensing receptor (CaSR) and fibroblast growth factor 23 (FGF-23) play central roles in the regulation of calcium and phosphorus metabolism, respectively. Phosphorus 129-139 fibroblast growth factor 23 Homo sapiens 40-67 19615558-1 2009 The calcium sensing receptor (CaSR) and fibroblast growth factor 23 (FGF-23) play central roles in the regulation of calcium and phosphorus metabolism, respectively. Phosphorus 129-139 fibroblast growth factor 23 Homo sapiens 69-75 18854401-1 2009 CONTEXT: Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate. Phosphorus 81-91 fibroblast growth factor 23 Homo sapiens 108-135 18854401-1 2009 CONTEXT: Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate. Phosphorus 81-91 fibroblast growth factor 23 Homo sapiens 137-142 18687639-9 2008 Future studies might investigate whether FGF-23 is a potential biomarker that can be used to guide strategies for the management of phosphorus balance in patients with chronic kidney disease. Phosphorus 132-142 fibroblast growth factor 23 Homo sapiens 41-47 18368510-4 2008 We have reviewed novel data linking fibroblast growth factor 23 (FGF-23) to phosphorus and vitamin D homeostasis. Phosphorus 76-86 fibroblast growth factor 23 Homo sapiens 36-63 18368510-4 2008 We have reviewed novel data linking fibroblast growth factor 23 (FGF-23) to phosphorus and vitamin D homeostasis. Phosphorus 76-86 fibroblast growth factor 23 Homo sapiens 65-71 17506310-0 2007 [Regulation of phosphorus-vitamin D metabolism by FGF23]. Phosphorus 15-25 fibroblast growth factor 23 Homo sapiens 50-55 16735491-1 2006 CONTEXT: Fibroblast growth factor 23 (FGF-23) is important in the regulation of phosphorus and vitamin D metabolism. Phosphorus 80-90 fibroblast growth factor 23 Homo sapiens 9-36 16735491-1 2006 CONTEXT: Fibroblast growth factor 23 (FGF-23) is important in the regulation of phosphorus and vitamin D metabolism. Phosphorus 80-90 fibroblast growth factor 23 Homo sapiens 38-44 16735491-3 2006 Conversely, states of absent or biologically inactive circulating FGF-23 are associated with increased serum phosphorus and 1,25(OH)(2)D concentrations. Phosphorus 109-119 fibroblast growth factor 23 Homo sapiens 66-72 16735491-5 2006 OBJECTIVE: We sought to determine whether serum FGF-23 concentration is regulated by dietary phosphorus and thereby mediates the physiological response of serum 1,25(OH)(2)D to changes in dietary phosphorus. Phosphorus 93-103 fibroblast growth factor 23 Homo sapiens 48-54 16735491-5 2006 OBJECTIVE: We sought to determine whether serum FGF-23 concentration is regulated by dietary phosphorus and thereby mediates the physiological response of serum 1,25(OH)(2)D to changes in dietary phosphorus. Phosphorus 196-206 fibroblast growth factor 23 Homo sapiens 48-54 16735491-10 2006 RESULTS: Serum FGF-23 concentrations decreased significantly from 30.7 +/- 8.7 pg/ml during phosphorus supplementation to 19.6 +/- 7.0 pg/ml during phosphorus restriction. Phosphorus 92-102 fibroblast growth factor 23 Homo sapiens 15-21 16735491-10 2006 RESULTS: Serum FGF-23 concentrations decreased significantly from 30.7 +/- 8.7 pg/ml during phosphorus supplementation to 19.6 +/- 7.0 pg/ml during phosphorus restriction. Phosphorus 148-158 fibroblast growth factor 23 Homo sapiens 15-21 16735491-13 2006 CONCLUSIONS: We conclude that in healthy men, changes in dietary phosphorus within the physiological range of intakes regulate serum FGF-23 concentrations and suggest that dietary phosphorus regulation of 1,25(OH)(2)D production is mediated, at least in part, by changes in circulating FGF-23. Phosphorus 65-75 fibroblast growth factor 23 Homo sapiens 133-139 16735491-13 2006 CONCLUSIONS: We conclude that in healthy men, changes in dietary phosphorus within the physiological range of intakes regulate serum FGF-23 concentrations and suggest that dietary phosphorus regulation of 1,25(OH)(2)D production is mediated, at least in part, by changes in circulating FGF-23. Phosphorus 180-190 fibroblast growth factor 23 Homo sapiens 286-292 16691036-5 2006 RESULTS: Plasma FGF-23 correlated with creatinine clearance (r2 = -0.584, p < 0.0001) and plasma phosphorus (r2 = 0.347, p < 0.001) in CKD patients and with plasma phosphorus (r2 = 0.448, p < 0.001) in end-stage renal disease patients. Phosphorus 170-180 fibroblast growth factor 23 Homo sapiens 16-22 16691036-8 2006 In patients with post-transplant hypophosphatemia, FGF-23 levels correlated inversely with plasma phosphorus (r2 = 0.661, p < 0.05). Phosphorus 98-108 fibroblast growth factor 23 Homo sapiens 51-57 16691036-10 2006 CONCLUSIONS: In CKD, FGF-23 levels rose with decreasing creatinine clearance rates and increasing plasma phosphorus levels, and rapidly decreased post-transplantation suggesting FGF-23 is cleared by the kidney. Phosphorus 105-115 fibroblast growth factor 23 Homo sapiens 21-27 15332221-6 2004 RESULTS: Preoperative FGF-23 levels correlated positively with phosphorus (P < 0.05), calcium-phosphorus product (Ca x P; P < 0.0005), and PTH values (P < 0.05). Phosphorus 63-73 fibroblast growth factor 23 Homo sapiens 22-28 15332221-9 2004 Furthermore, FGF-23 levels days 1 and 3 correlated linearly with serum phosphorus (P < 0.05; P < 0.005, respectively) and Ca x P values (P < 0.01; P < 0.0001, respectively). Phosphorus 71-81 fibroblast growth factor 23 Homo sapiens 13-19 15332221-10 2004 CONCLUSION: FGF-23 levels correlate positively with serum phosphorus, Ca x P, and PTH values in patients with advanced secondary hyperparathyroidism. Phosphorus 58-68 fibroblast growth factor 23 Homo sapiens 12-18 15332221-10 2004 CONCLUSION: FGF-23 levels correlate positively with serum phosphorus, Ca x P, and PTH values in patients with advanced secondary hyperparathyroidism. Phosphorus 75-76 fibroblast growth factor 23 Homo sapiens 12-18 15356053-1 2004 The Identification and characterization of FGF-23 has provided an opportunity to gain new insight into phosphorus metabolism. Phosphorus 103-113 fibroblast growth factor 23 Homo sapiens 43-49 15356053-2 2004 Circulating FGF-23 promotes renal excretion of phosphorus, and FGF-23 is measurable in the serum of normal subjects. Phosphorus 47-57 fibroblast growth factor 23 Homo sapiens 12-18 15356053-10 2004 In conclusion, serum FGF-23 levels are elevated in patients with hyperphosphatemia and chronic hypoparathyroidism, suggesting a feedback system in which serum FGF-23 responds to serum phosphorus and regulates it. Phosphorus 184-194 fibroblast growth factor 23 Homo sapiens 21-27 15356053-10 2004 In conclusion, serum FGF-23 levels are elevated in patients with hyperphosphatemia and chronic hypoparathyroidism, suggesting a feedback system in which serum FGF-23 responds to serum phosphorus and regulates it. Phosphorus 184-194 fibroblast growth factor 23 Homo sapiens 159-165 12854832-10 2003 There was a strong inverse correlation between FGF23 and serum phosphorus (r = -0.60) and calcium and phosphorus (Ca x P) product (r = -0.65) in XLH, and a strong positive relationship between FGF23 and Pi (r = 0.50) and Ca x P product (r = 0.62) in ESRD. Phosphorus 63-73 fibroblast growth factor 23 Homo sapiens 47-52 12419819-2 2003 The hFGF23 mutants (R176Q, R179Q, and R179W) markedly reduced serum phosphorus (6.2-6.9 mg/dl) compared with the plasmid MOCK (8.5 mg/dl). Phosphorus 68-78 fibroblast growth factor 23 Homo sapiens 4-10 24682550-1 2015 BACKGROUND/AIMS: Fibroblast growth factor 23 (FGF23) and soluble alpha-Klotho are emerging potential biomarkers of phosphorus and vitamin D metabolism which change in concentration in early chronic kidney disease (CKD) in order to maintain normal phosphorus levels. Phosphorus 115-125 fibroblast growth factor 23 Homo sapiens 17-44 34930854-1 2021 INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland. Phosphorus 98-108 fibroblast growth factor 23 Homo sapiens 14-41 34930854-1 2021 INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland. Phosphorus 98-108 fibroblast growth factor 23 Homo sapiens 43-48 34659853-7 2021 In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Phosphorus 71-81 fibroblast growth factor 23 Homo sapiens 26-32 34659853-7 2021 In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Phosphorus 124-134 fibroblast growth factor 23 Homo sapiens 26-32 34659853-7 2021 In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Phosphorus 237-247 fibroblast growth factor 23 Homo sapiens 26-32 34268038-20 2021 Interestingly, FGF-23 is shown to have a potential cardiovascular (CV) morbidity and mortality through various mechanisms like activation of myocardial FGF-23 receptors, endothelial dysfunction, inflammation, and altered phosphorus and vitamin D metabolisms. Phosphorus 221-231 fibroblast growth factor 23 Homo sapiens 15-21 34068220-4 2021 Parathyroid hormone (PTH), Vitamin D, Fibroblast Growth Factor (FGF23) and other receptors or ion-transporters, work synergistically and establish a highly regulated signalling circuit between the bone, kidneys, and intestine to ensure the maintenance of Ca and P homeostasis. Phosphorus 262-263 fibroblast growth factor 23 Homo sapiens 64-69 35613118-5 2022 In sex-stratified analyses, we examined the cross-sectional associations between log-transformed sex hormones (per 1 SD) and log-transformed FGF-23 using multiple linear regression adjusted for socio-demographics, CVD risk factors, estimated glomerular filtration rate and mineral metabolites (25-hydroxyvitamin D, calcium, phosphorus and parathyroid hormone). Phosphorus 324-334 fibroblast growth factor 23 Homo sapiens 141-147 34448875-3 2022 OBJECTIVE: To investigate the acute effect of excessive dietary phosphorus administered as sodium-dihydrogen phosphate on the postprandial levels of Pi and FGF23 and the response to food. Phosphorus 64-74 fibroblast growth factor 23 Homo sapiens 156-161 34011663-5 2021 Treatment with burosumab (an anti-FGF23 monoclonal antibody) normalised phosphorus and alkaline phosphatase levels and improved her bowing. Phosphorus 72-82 fibroblast growth factor 23 Homo sapiens 34-39 33471363-2 2021 Phosphorus homeostasis can be affected by diet and certain medications; some intravenous iron formulations can induce renal phosphate excretion and hypophosphatemia, likely through increasing serum concentrations of intact fibroblast growth factor 23. Phosphorus 0-10 fibroblast growth factor 23 Homo sapiens 223-250 33832448-3 2021 In addition, fibroblast growth factor 23 (FGF23), which has been recognized as a phosphorus-regulating hormone, appears to be involved in haematopoietic regulation. Phosphorus 81-91 fibroblast growth factor 23 Homo sapiens 13-40 33832448-3 2021 In addition, fibroblast growth factor 23 (FGF23), which has been recognized as a phosphorus-regulating hormone, appears to be involved in haematopoietic regulation. Phosphorus 81-91 fibroblast growth factor 23 Homo sapiens 42-47 33912412-1 2021 Objective: Homeostasis of serum phosphorus and calcitriol level is regulated mainly by fibroblast growth factor 23 (FGF23). Phosphorus 32-42 fibroblast growth factor 23 Homo sapiens 87-114 33912412-1 2021 Objective: Homeostasis of serum phosphorus and calcitriol level is regulated mainly by fibroblast growth factor 23 (FGF23). Phosphorus 32-42 fibroblast growth factor 23 Homo sapiens 116-121 33308018-8 2021 We demonstrated that the incorporation of FGF23 and the soft tissue compartment is essential for accurate modeling of the changes in calcium, phosphorus, iPTH and calcitriol in CKD-MBD. Phosphorus 142-152 fibroblast growth factor 23 Homo sapiens 42-47 32743932-8 2021 RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use. Phosphorus 138-148 fibroblast growth factor 23 Homo sapiens 40-45 33306729-1 2020 BACKGROUND: Concentrations of fibroblast growth factor 23 (FGF-23), a hormone that regulates phosphorus and vitamin D metabolism, increase as kidney function declines. Phosphorus 93-103 fibroblast growth factor 23 Homo sapiens 30-57 33306729-1 2020 BACKGROUND: Concentrations of fibroblast growth factor 23 (FGF-23), a hormone that regulates phosphorus and vitamin D metabolism, increase as kidney function declines. Phosphorus 93-103 fibroblast growth factor 23 Homo sapiens 59-65 32901861-0 2020 Fortified phosphorus-lowering treatment through administration of lanthanum protects against vascular calcification via regulation of FGF23 in chronic kidney disease. Phosphorus 10-20 fibroblast growth factor 23 Homo sapiens 134-139 33015068-2 2020 Physiologically, the maintenance of calcium and phosphorus homeostasis is achieved via a variety of concerted actions of hormones such as parathyroid hormone (PTH), vitamin D, and fibroblast growth factor (FGF23), which could be regulated mainly at three organs, the intestine, kidney, and bone. Phosphorus 48-58 fibroblast growth factor 23 Homo sapiens 206-211 33015068-7 2020 Therefore, in this review, we will give a systematic introduction on PTH-1,25(OH)2D-FGF23 axis in the disorders of calcium and phosphorus metabolism, diagnostic biomarkers identified, and potential altered metabolic pathways involved. Phosphorus 127-137 fibroblast growth factor 23 Homo sapiens 84-89 32418499-1 2020 FGF-23 (fibroblast growth factor 23) regulates phosphorus and vitamin D. Phosphorus 47-57 fibroblast growth factor 23 Homo sapiens 0-6 32418499-1 2020 FGF-23 (fibroblast growth factor 23) regulates phosphorus and vitamin D. Phosphorus 47-57 fibroblast growth factor 23 Homo sapiens 8-35 31919781-6 2020 In addition, some molecules involved in calcium/phosphorus metabolism, such as klotho and FGF23, have an involvement in the pathogenesis of diabetic vasculopathy, which appears to be dependent on the degree of vascular impairment. Phosphorus 48-58 fibroblast growth factor 23 Homo sapiens 90-95 33015612-12 2020 The magnitude of the FGF-23 level reductions was strongly associated with concomitant changes in serum phosphorus levels but not with the changes in intact parathyroid hormone levels. Phosphorus 103-113 fibroblast growth factor 23 Homo sapiens 21-27 33015612-16 2020 These results suggest that phosphorus is a strong inducer of FGF-23 production and that regulation of FGF-23 production is a rapid process. Phosphorus 27-37 fibroblast growth factor 23 Homo sapiens 61-67 31831119-3 2019 Mineral bone abnormalities are common in chronic kidney disease; reduction in glomerular filtration rate and changes in vitamin D, parathyroid hormone, and fibroblast growth factor 23 result in the dysregulation of phosphorus and calcium metabolism. Phosphorus 215-225 fibroblast growth factor 23 Homo sapiens 156-183 31384956-3 2019 Serum FGF23 was negatively correlated with serum phosphorus. Phosphorus 49-59 fibroblast growth factor 23 Homo sapiens 6-11 31384956-5 2019 INTRODUCTION: FGF23 is involved in the mineral homeostasis, especially the regulation of serum phosphorus. Phosphorus 95-105 fibroblast growth factor 23 Homo sapiens 14-19 31384956-12 2019 Serum FGF23 was significantly and negatively correlated with phosphorus level after adjusted for age, gender, calcium, iPTH, and 25(OH)D in the euthyroid GD group. Phosphorus 61-71 fibroblast growth factor 23 Homo sapiens 6-11 31384956-14 2019 Serum FGF23 was negatively correlated with serum phosphorus in euthyroid GD patients. Phosphorus 49-59 fibroblast growth factor 23 Homo sapiens 6-11 31599133-1 2019 Fibroblast growth factor 23 (FGF23), one of the endocrine fibroblast growth factors, is a principal regulator in the maintenance of serum phosphorus concentration. Phosphorus 138-148 fibroblast growth factor 23 Homo sapiens 0-27 31599133-1 2019 Fibroblast growth factor 23 (FGF23), one of the endocrine fibroblast growth factors, is a principal regulator in the maintenance of serum phosphorus concentration. Phosphorus 138-148 fibroblast growth factor 23 Homo sapiens 29-34 31599133-4 2019 FGF23 reduces serum phosphorus concentration through decreased reabsorption of phosphorus in the kidney and by decreasing 1,25 dihydroxyvitamin D (1,25(OH)2D) concentrations. Phosphorus 20-30 fibroblast growth factor 23 Homo sapiens 0-5 31599133-4 2019 FGF23 reduces serum phosphorus concentration through decreased reabsorption of phosphorus in the kidney and by decreasing 1,25 dihydroxyvitamin D (1,25(OH)2D) concentrations. Phosphorus 79-89 fibroblast growth factor 23 Homo sapiens 0-5 31037817-1 2019 FGF-23 is a 32 kDa protein that is a key regulator of phosphorus and vitamin D metabolism. Phosphorus 54-64 fibroblast growth factor 23 Homo sapiens 0-6 30465136-4 2019 RESULTS: High levels of FGF-23 correlated with longer duration of dialysis (p = 0.002), elevated levels of calcium (p < 0.001), phosphorus (p = 0.037) and low density lipoprotein cholesterol (p = 0.027). Phosphorus 131-141 fibroblast growth factor 23 Homo sapiens 24-30 31218207-2 2019 Elevated serum phosphorus and 1,25dihydroxyvitaminD stimulates FGF23 production to promote renal phosphate excretion and decrease 1,25dihydroxyvitaminD synthesis. Phosphorus 15-25 fibroblast growth factor 23 Homo sapiens 63-68 29660161-1 2018 BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. Phosphorus 143-153 fibroblast growth factor 23 Homo sapiens 12-39 29660161-1 2018 BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. Phosphorus 143-153 fibroblast growth factor 23 Homo sapiens 41-47 29660161-8 2018 In hospitalised and septic foals, increased FGF-23 and aldosterone concentrations were associated with high phosphorus and PTH but not with TCa and vitamin D metabolite concentrations. Phosphorus 108-118 fibroblast growth factor 23 Homo sapiens 44-50 29660161-12 2018 Elevated FGF-23 and reduced klotho, together with high phosphorus and PTH concentrations suggests FGF-23 resistance. Phosphorus 55-65 fibroblast growth factor 23 Homo sapiens 98-104 30413250-4 2018 However, assessment and treatment of MBD is rife with challenges owing to biological tensions between its many components, such as calcium and phosphorus with their regulatory hormones fibroblast growth factor 23 and parathyroid hormone; fibroblast growth factor 23 with its co-receptor klotho; and vitamin D with control of calcium and phosphorus. Phosphorus 143-153 fibroblast growth factor 23 Homo sapiens 185-236 30217807-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Phosphorus 87-97 fibroblast growth factor 23 Homo sapiens 12-39 30217807-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Phosphorus 87-97 fibroblast growth factor 23 Homo sapiens 41-46 30249044-3 2018 Phosphorus is regulated by multiple hormones (parathyroid hormone (PTH), 1,25-dihyxdroxyvitamin D (1,25D), and fibroblast growth factor 23 (FGF23)) and tissues (kidney, intestine, parathyroid glands, and bone) to maintain homeostasis. Phosphorus 0-10 fibroblast growth factor 23 Homo sapiens 111-138 30249044-3 2018 Phosphorus is regulated by multiple hormones (parathyroid hormone (PTH), 1,25-dihyxdroxyvitamin D (1,25D), and fibroblast growth factor 23 (FGF23)) and tissues (kidney, intestine, parathyroid glands, and bone) to maintain homeostasis. Phosphorus 0-10 fibroblast growth factor 23 Homo sapiens 140-145 29633705-2 2018 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism. Phosphorus 85-95 fibroblast growth factor 23 Homo sapiens 0-27 29633705-2 2018 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism. Phosphorus 85-95 fibroblast growth factor 23 Homo sapiens 29-34 30701904-10 2018 A direct correlation (r=0.445; p&lt;0.05) was established between FGF-23 serum levels and serum phosphorus, which was more pronounced in HD patients (r=0.545; p&lt;0.01). Phosphorus 100-110 fibroblast growth factor 23 Homo sapiens 70-76 29886473-5 2018 Presently, there are several ways to reduce FGF23 levels, including decrease of intake and block of phosphorus absorption, supplement of FGF23 antibody and pseudo calcium or renal transplantation. Phosphorus 100-110 fibroblast growth factor 23 Homo sapiens 44-49 29669938-9 2018 The increase in plasma FGF23 was correlated with the increase in serum phosphorus, and the decrease in plasma 1,25-dihydroxyvitamin D was correlated with the increase in plasma FGF23. Phosphorus 71-81 fibroblast growth factor 23 Homo sapiens 23-28 29669938-10 2018 CONCLUSIONS: Canagliflozin induced a prompt increase in serum phosphorus, which triggers downstream changes in FGF23, 1,25-dihydroxyvitamin D, and PTH, with potential to exert adverse effects on bone health. Phosphorus 62-72 fibroblast growth factor 23 Homo sapiens 111-116 29679282-3 2018 Inhibition of FGF23 by burosumab results in increased renal phosphate reabsorption and increased serum levels of phosphorus and active vitamin D. Phosphorus 113-123 fibroblast growth factor 23 Homo sapiens 14-19 29621752-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Phosphorus 77-87 fibroblast growth factor 23 Homo sapiens 12-39 29621752-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Phosphorus 77-87 fibroblast growth factor 23 Homo sapiens 41-47 28619026-10 2017 Furthermore, this relationship remained significant after additional adjustment for gender and factors potentially affecting serum FGF23 levels (serum calcium, serum phosphorus, and glomerular filtration rate), respectively (both P < 0.01). Phosphorus 166-176 fibroblast growth factor 23 Homo sapiens 131-136 27826644-2 2017 Great deal of data has accumulated to demonstrate increased FGF23 secretion from the bone to compensate for even subtle increases in serum phosphorus long before intact PTH. Phosphorus 139-149 fibroblast growth factor 23 Homo sapiens 60-65 28110703-5 2017 High dietary intakes of bioavailable phosphorus and of calcium have been found to boost FGF23 levels, and this accords well with prospective epidemiology pointing to high intakes of both phosphate and calcium as risk factors for aggressive prostate cancer. Phosphorus 37-47 fibroblast growth factor 23 Homo sapiens 88-93 29179169-3 2017 Vitamin D stimulates intestinal phosphorus absorption, and phosphorus promotes FGF23 secretion from osteocytes. Phosphorus 59-69 fibroblast growth factor 23 Homo sapiens 79-84 28182071-5 2017 FGF-23 levels were significantly associated with serum phosphorus and parathyroid hormone (PTH) levels in univariate and multivariate analysis. Phosphorus 55-65 fibroblast growth factor 23 Homo sapiens 0-6 28182071-8 2017 There is a strong association between FGF-23 and phosphorus and PTH levels. Phosphorus 49-59 fibroblast growth factor 23 Homo sapiens 38-44 27820122-4 2017 The patient was treated with oral phosphorus and calcitriol, surgical debulking, and intralesional corticosteroids, which resulted in tumor regression and normalization of serum fibroblast growth factor 23 and phosphorus. Phosphorus 34-44 fibroblast growth factor 23 Homo sapiens 178-205 27867811-0 2016 Dramatic mitigation of bone pain after phosphorus replacement therapy in a subject with FGF23-related hypophosphatemic osteomalacia. Phosphorus 39-49 fibroblast growth factor 23 Homo sapiens 88-93 27867811-1 2016 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is secreted from bone and suppresses the absorption of phosphorus in renal proximal tubule and in intestinal tract. Phosphorus 105-115 fibroblast growth factor 23 Homo sapiens 14-41 27867811-1 2016 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is secreted from bone and suppresses the absorption of phosphorus in renal proximal tubule and in intestinal tract. Phosphorus 105-115 fibroblast growth factor 23 Homo sapiens 43-48 27867811-7 2016 CONCLUSIONS: We should be aware of the possibility that phosphorus replacement therapy exert marked beneficial effects for the reduction of bone pain in subjects with FGF23-related hypophosphatemic osteomalacia even when we fail to identify tumor localization. Phosphorus 56-66 fibroblast growth factor 23 Homo sapiens 167-172 28087877-1 2016 The article incorrectly stated: "Elevations of both fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) lead to hyperphosphatemia and hypocalcemia because of decreased urinary excretion of phosphorus." Phosphorus 203-213 fibroblast growth factor 23 Homo sapiens 52-79 28087877-1 2016 The article incorrectly stated: "Elevations of both fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) lead to hyperphosphatemia and hypocalcemia because of decreased urinary excretion of phosphorus." Phosphorus 203-213 fibroblast growth factor 23 Homo sapiens 81-86 27164190-2 2016 The result is functional deficiency of, or resistance to, intact FGF23 (iFGF23), causing hyperphosphatemia, increased renal tubular reabsorption of phosphorus (TRP), elevated or inappropriately normal 1,25-dihydroxyvitamin D3 (1,25D), ectopic calcifications, and/or diaphyseal hyperostosis. Phosphorus 148-158 fibroblast growth factor 23 Homo sapiens 65-70 28298956-1 2016 Serum phosphorus levels stay relatively constant through the influence of multiple factors-such as parathyroid hormone, fibroblast growth factor 23, and vitamin D-on the kidney, bone, and digestive system. Phosphorus 6-16 fibroblast growth factor 23 Homo sapiens 120-147 26790456-6 2016 Fibroblast growth factor 23 is produced by osteocytes to regulate phosphorus and 1,25(OH)2D3, but it also plays a major role in the adverse consequences of declining renal function, in particular with respect to the myocardium. Phosphorus 66-76 fibroblast growth factor 23 Homo sapiens 0-27 28497083-0 2017 Impact of FGF23 level on calcium and phosphorus levels in post-renal transplantation. Phosphorus 37-47 fibroblast growth factor 23 Homo sapiens 10-15 28497083-9 2017 Conclusion: The level of postoperative FGF23 is an important marker for secretion of phosphorus from kidneys emphasizing the central role of FGF23 marker to regulate calcium and phosphorus metabolism after a successful renal transplantation. Phosphorus 85-95 fibroblast growth factor 23 Homo sapiens 39-44 27721584-1 2016 BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Phosphorus 123-133 fibroblast growth factor 23 Homo sapiens 29-56 27721584-1 2016 BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Phosphorus 123-133 fibroblast growth factor 23 Homo sapiens 58-64 27191351-1 2016 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes and osteoblasts that regulates phosphorus and vitamin D homeostasis. Phosphorus 122-132 fibroblast growth factor 23 Homo sapiens 19-46 27191351-1 2016 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes and osteoblasts that regulates phosphorus and vitamin D homeostasis. Phosphorus 122-132 fibroblast growth factor 23 Homo sapiens 48-53 26928188-1 2016 UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D. Phosphorus 121-131 fibroblast growth factor 23 Homo sapiens 69-96 26928188-1 2016 UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D. Phosphorus 121-131 fibroblast growth factor 23 Homo sapiens 98-103 27176000-8 2016 Among HIV-positive persons, factors independently associated with higher baseline FGF23 levels included female (adjusted ratio of geometric means [95% CI],1.46 [1.21,1.76]), serum phosphorus (1.20 [1.03,1.40]), HCV (1.31 [1.10,1.56]) and non-suppressed HIV RNA (1.27 [1.01,1.76]). Phosphorus 180-190 fibroblast growth factor 23 Homo sapiens 82-87 26965530-10 2016 Phosphorus correlated with intact FGF23 (white women, r=0.120, p<0.0001; black women r=0.163, p<0.01). Phosphorus 0-10 fibroblast growth factor 23 Homo sapiens 34-39 26965530-11 2016 However, phosphorus correlated with C-terminal FGF23 only in black women (r=0.157, p<0.01). Phosphorus 9-19 fibroblast growth factor 23 Homo sapiens 47-52 26965530-19 2016 Intact FGF23 correlated with serum phosphorus. Phosphorus 35-45 fibroblast growth factor 23 Homo sapiens 7-12 26773479-9 2016 The importance of FGF-23 (phosphatonin) and parathyroid hormone in normalizing the dramatic changes in plasma calcium and phosphorus during the 24h egg-laying cycle is discussed. Phosphorus 122-132 fibroblast growth factor 23 Homo sapiens 18-24 25770169-6 2016 Despite FGF-23 and PTH having synergic effects regarding phosphorus removal, they have opposite effects on 1,25(OH)2D3. Phosphorus 57-67 fibroblast growth factor 23 Homo sapiens 8-14 26813507-1 2016 FGF23-related hypophosphatemic rickets is basically treated with active vitamin D and phosphorus. Phosphorus 86-96 fibroblast growth factor 23 Homo sapiens 0-5 26786148-13 2016 Plasma FGF23 concentrations increased four weeks after high phosphorus intake and normalized after eight weeks. Phosphorus 60-70 fibroblast growth factor 23 Homo sapiens 7-12 27440690-4 2016 The objective of this cross-sectional study was to examine the relationship between serum FGF-23 concentrations and phosphorus related factors in 182 young Japanese women (mean age, 19.5+-0.4 years). Phosphorus 116-126 fibroblast growth factor 23 Homo sapiens 90-96 27440690-5 2016 We found that higher serum concentrations of inorganic phosphorus and lower serum concentrations of 1,25-dihydroxy vitamin D as well as lower fat but higher phosphorus and calcium intake were weakly but significantly associated with high serum concentrations of FGF-23, adjusted for postmenarcheal age and body weight. Phosphorus 55-65 fibroblast growth factor 23 Homo sapiens 262-268 27440690-6 2016 These results suggested that in young Japanese women, serum FGF-23 might be indicative of phosphorus nutrition status. Phosphorus 90-100 fibroblast growth factor 23 Homo sapiens 60-66 27040054-0 2016 Effects of gender and body weight on fibroblast growth factor 23 responsiveness to estimated dietary phosphorus. Phosphorus 101-111 fibroblast growth factor 23 Homo sapiens 37-64 27040054-3 2016 The purpose of this study was to evaluate whether sex could influence FGF23 responsiveness to dietary phosphorus intake in healthy individuals. Phosphorus 102-112 fibroblast growth factor 23 Homo sapiens 70-75 27070162-7 2016 Along with this, a strong direct correlation (r=0.522; p<0.001) was found between the concentration of FGF-23 in the serum and inorganic phosphorus; at the same time hyperphosphatemia was less significantly associated with higher serum intact parathyroid hormone (PTH) levels (r=0.398; p<0.05). Phosphorus 140-150 fibroblast growth factor 23 Homo sapiens 106-112 27081473-4 2015 There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). Phosphorus 47-57 fibroblast growth factor 23 Homo sapiens 40-45 27194998-1 2015 BACKGROUND: The osteocyte-derived hormone, fibroblast growth factor 23 (FGF23), regulates the phosphorus metabolism and suppresses 1,25-dihydroxyvitamin D production, thereby mitigating hyperphosphatemia in patients with renal disorders. Phosphorus 94-104 fibroblast growth factor 23 Homo sapiens 43-70 27194998-1 2015 BACKGROUND: The osteocyte-derived hormone, fibroblast growth factor 23 (FGF23), regulates the phosphorus metabolism and suppresses 1,25-dihydroxyvitamin D production, thereby mitigating hyperphosphatemia in patients with renal disorders. Phosphorus 94-104 fibroblast growth factor 23 Homo sapiens 72-77 27194998-2 2015 An elevated FGF23 level is suggested to be an early biomarker of altered phosphorus metabolism in the initial stages of chronic kidney disease (CKD) and acts as a strong predictor of mortality in dialysis patients. Phosphorus 73-83 fibroblast growth factor 23 Homo sapiens 12-17 26018436-2 2015 However, over the past decade, substantial advances have been made in understanding the control of phosphorus by the so-called phosphatonin system, the lynchpin of which is fibroblast growth factor 23 (FGF23). Phosphorus 99-109 fibroblast growth factor 23 Homo sapiens 173-200 26018436-2 2015 However, over the past decade, substantial advances have been made in understanding the control of phosphorus by the so-called phosphatonin system, the lynchpin of which is fibroblast growth factor 23 (FGF23). Phosphorus 99-109 fibroblast growth factor 23 Homo sapiens 202-207 26018436-3 2015 FGF23 binds to the klotho/FGFR1c receptor complex in renal tubular epithelial cells, leading to upregulation of Na/Pi cotransporters and subsequent excretion of phosphorus from the body. Phosphorus 161-171 fibroblast growth factor 23 Homo sapiens 0-5 26321027-6 2015 In hypertensive patients, urine FGF23/creatinine positively correlated with serum calcium and negatively with serum 25(OH)D, urinary calcium, phosphorus, and magnesium. Phosphorus 142-152 fibroblast growth factor 23 Homo sapiens 32-37 26338395-3 2015 New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus. Phosphorus 199-209 fibroblast growth factor 23 Homo sapiens 66-93 26338395-3 2015 New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus. Phosphorus 199-209 fibroblast growth factor 23 Homo sapiens 95-101 24939836-5 2015 Furthermore, blood calcium and phosphorus homeostasis is maintained by an interplay between feedback loops of the 1,25(OH)2D/VDR system with parathyroid hormone and with fibroblast-growth factor (FGF) 23 respectively. Phosphorus 31-41 fibroblast growth factor 23 Homo sapiens 170-203