PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8464327-6 1993 After long-term EB or EH-NX, followed by short-term oil treatment, the pituitary LH response to LHRH was increased considerably, compared to the long-term oil controls. estradiol 3-benzoate 16-18 gonadotropin releasing hormone 1 Rattus norvegicus 96-100 7627270-5 1995 In the CA1 region of castrated EB-treated female rats, the predominant effect of LHRH was facilitation and the ratio of facilitation, inhibition and no response was not significantly different from that in castrated EB-untreated female rats. estradiol 3-benzoate 31-33 gonadotropin releasing hormone 1 Rattus norvegicus 81-85 11999719-3 2002 LHRH was low 24 h after oestradiol benzoate injection, increasing up to 15 days later; LH, FSH, oestradiol and progesterone ranged from high values 24 h after oestradiol benzoate injection to low 15 days later; prolactin ranged from low concentration 24 h after oestradiol benzoate injection to high 15 days later. estradiol 3-benzoate 24-43 gonadotropin releasing hormone 1 Rattus norvegicus 0-4 3528895-4 1986 Administration of EB increased the activity of the LH-RH pulse generator as indicated by a significant increase in overall mean LH-RH release of EB- versus oil-treated females. estradiol 3-benzoate 18-20 gonadotropin releasing hormone 1 Rattus norvegicus 51-56 3121935-1 1987 The present experiments were designed to study the interaction between estradiol benzoate (EB) and thyroxine (T4) given in vivo on the responsiveness of pituitary luteinizing hormone (LH) to gonadotropin-releasing hormone (GnRH) and the release of GnRH in vitro. estradiol 3-benzoate 71-89 gonadotropin releasing hormone 1 Rattus norvegicus 191-221 3121935-1 1987 The present experiments were designed to study the interaction between estradiol benzoate (EB) and thyroxine (T4) given in vivo on the responsiveness of pituitary luteinizing hormone (LH) to gonadotropin-releasing hormone (GnRH) and the release of GnRH in vitro. estradiol 3-benzoate 91-93 gonadotropin releasing hormone 1 Rattus norvegicus 191-221 3121935-8 1987 The serum LH levels and the spontaneous as well as the GnRH-stimulated release of LH in vitro were suppressed in Ovx-Tx rats following administration of EB. estradiol 3-benzoate 153-155 gonadotropin releasing hormone 1 Rattus norvegicus 55-59 3121935-9 1987 By contrast, the serum LH concentration, as well as pituitary LH response to GnRH and GnRH release in vitro, were higher in the group treated with both T4 and EB than in that treated with saline and EB. estradiol 3-benzoate 159-161 gonadotropin releasing hormone 1 Rattus norvegicus 77-81 3121935-9 1987 By contrast, the serum LH concentration, as well as pituitary LH response to GnRH and GnRH release in vitro, were higher in the group treated with both T4 and EB than in that treated with saline and EB. estradiol 3-benzoate 159-161 gonadotropin releasing hormone 1 Rattus norvegicus 86-90 3926532-1 1985 In the long-term ovariectomized rat, both estradiol benzoate (EB) and clomiphene citrate enhance the release of LH induced by luteinizing hormone-releasing hormone (LHRH). estradiol 3-benzoate 42-60 gonadotropin releasing hormone 1 Rattus norvegicus 126-163 3926532-1 1985 In the long-term ovariectomized rat, both estradiol benzoate (EB) and clomiphene citrate enhance the release of LH induced by luteinizing hormone-releasing hormone (LHRH). estradiol 3-benzoate 42-60 gonadotropin releasing hormone 1 Rattus norvegicus 165-169 3926532-1 1985 In the long-term ovariectomized rat, both estradiol benzoate (EB) and clomiphene citrate enhance the release of LH induced by luteinizing hormone-releasing hormone (LHRH). estradiol 3-benzoate 62-64 gonadotropin releasing hormone 1 Rattus norvegicus 126-163 3926532-1 1985 In the long-term ovariectomized rat, both estradiol benzoate (EB) and clomiphene citrate enhance the release of LH induced by luteinizing hormone-releasing hormone (LHRH). estradiol 3-benzoate 62-64 gonadotropin releasing hormone 1 Rattus norvegicus 165-169 3926532-3 1985 In rats pretreated with LHRH, EB strongly depresses the LHRH-induced LH/FSH release, but clomiphene enhances this release, regardless of the presence of EB. estradiol 3-benzoate 30-32 gonadotropin releasing hormone 1 Rattus norvegicus 24-28 3926532-3 1985 In rats pretreated with LHRH, EB strongly depresses the LHRH-induced LH/FSH release, but clomiphene enhances this release, regardless of the presence of EB. estradiol 3-benzoate 30-32 gonadotropin releasing hormone 1 Rattus norvegicus 56-60 2036964-5 1991 Treatment of ovariectomized rats with estradiol benzoate and progesterone in a regimen which induces a preovulatory-like LH surge, antagonized morphine-induced hypothermia, and the LHRH antagonist [D-Phe2, Pro3, D-Phe6] LHRH, reversed the effects of the gonadal steroids. estradiol 3-benzoate 38-56 gonadotropin releasing hormone 1 Rattus norvegicus 181-185 2125702-1 1990 Both the luteinizing-hormone-releasing hormone (LHRH) decapeptide and an LHRH fragment consisting of the last 6 amino acids of the decapeptide, Ac-LHRH, have been shown to enhance lordosis behavior in ovariectomized, estradiol-benzoate treated female rats. estradiol 3-benzoate 217-235 gonadotropin releasing hormone 1 Rattus norvegicus 73-77 2125702-1 1990 Both the luteinizing-hormone-releasing hormone (LHRH) decapeptide and an LHRH fragment consisting of the last 6 amino acids of the decapeptide, Ac-LHRH, have been shown to enhance lordosis behavior in ovariectomized, estradiol-benzoate treated female rats. estradiol 3-benzoate 217-235 gonadotropin releasing hormone 1 Rattus norvegicus 73-77 3075044-5 1988 In sexually experienced Ss (tested on two previous occasions with EB and LHRH) the administration of EB alone on a third test induced significant levels of lordosis (mean LQ = 51 +/- 41). estradiol 3-benzoate 101-103 gonadotropin releasing hormone 1 Rattus norvegicus 73-77 3140673-4 1988 In ovariectomized (OVX), estradiol benzoate-progesterone-treated R rats, low doses (less than 5 ng/100 g body wt) of GnRH injected intravenously produced higher serum luteinizing hormone (LH) concentration than in comparable C rats. estradiol 3-benzoate 25-43 gonadotropin releasing hormone 1 Rattus norvegicus 117-121 2956530-2 1987 The percentage of change in firing rate was evaluated to determine the effect of exogenously administered estradiol benzoate (EB) and EB plus progesterone (EB + P) on the membrane sensitivity of these MCG neurons to LHRH and beta-END. estradiol 3-benzoate 126-128 gonadotropin releasing hormone 1 Rattus norvegicus 216-220 2956530-2 1987 The percentage of change in firing rate was evaluated to determine the effect of exogenously administered estradiol benzoate (EB) and EB plus progesterone (EB + P) on the membrane sensitivity of these MCG neurons to LHRH and beta-END. estradiol 3-benzoate 134-136 gonadotropin releasing hormone 1 Rattus norvegicus 216-220 2956530-4 1987 EB priming significantly altered the membrane sensitivity of neurons in the MCG to LHRH by increasing the number of cells excited compared to the EB + P group and the nonprimed controls (p less than 0.005). estradiol 3-benzoate 0-2 gonadotropin releasing hormone 1 Rattus norvegicus 83-87 3528895-4 1986 Administration of EB increased the activity of the LH-RH pulse generator as indicated by a significant increase in overall mean LH-RH release of EB- versus oil-treated females. estradiol 3-benzoate 18-20 gonadotropin releasing hormone 1 Rattus norvegicus 128-133 3896027-1 1985 The LH response to 100 or 1000 ng of LH-RH was studied in adult male rats treated neonatally with 500 micrograms of estradiol benzoate or olive oil. estradiol 3-benzoate 116-134 gonadotropin releasing hormone 1 Rattus norvegicus 37-42 6988205-4 1980 Following a single injection of 5 micrograms of estradiol benzoate (EB), the LHRH concentration of the synaptosomal fraction rose as much as 100% in 27 h. Increasing the dose of EB to 50 micrograms shortened the latency of the rise and prolonged its duration, but did not alter its magnitude compared to the lower dose. estradiol 3-benzoate 48-66 gonadotropin releasing hormone 1 Rattus norvegicus 77-81 6426227-0 1984 Prolonged combined in vivo pre-treatment with luteinizing hormone-releasing hormone (LRH) and oestradiol benzoate causes long-lasting suppression of the autonomous and the LRH-stimulated secretion of luteinizing hormone and follicle stimulating hormone. estradiol 3-benzoate 94-113 gonadotropin releasing hormone 1 Rattus norvegicus 172-175 6360665-5 1984 On the other hand, the LHRH secretion pattern in vitro was different in two ways when rats were treated additionally with P. First, LHRH output was significantly higher at 1200 and 1400 h than that in rats treated with 10 or 30 micrograms EB only; this pattern was maintained later at 1600 and 1800 h from the POA-MBH of rats primed with 30 micrograms EB. estradiol 3-benzoate 239-241 gonadotropin releasing hormone 1 Rattus norvegicus 23-27 6356136-1 1983 The role of hypothalamic catecholamines and luteinizing hormone releasing hormone (LHRH) in the negative feedback effect of estradiol benzoate (EB) on luteinizing hormone (LH) release was studied in chronic ovariectomized rats. estradiol 3-benzoate 124-142 gonadotropin releasing hormone 1 Rattus norvegicus 83-87 6356136-1 1983 The role of hypothalamic catecholamines and luteinizing hormone releasing hormone (LHRH) in the negative feedback effect of estradiol benzoate (EB) on luteinizing hormone (LH) release was studied in chronic ovariectomized rats. estradiol 3-benzoate 144-146 gonadotropin releasing hormone 1 Rattus norvegicus 83-87 6356136-3 1983 Inhibition of dopamine and norepinephrine synthesis with alpha-methyl-p-tyrosine (alpha-MT) reduced the LHRH content in the MBH in both oil- and EB-treated animals and partially reversed the decrease in plasma LH levels. estradiol 3-benzoate 145-147 gonadotropin releasing hormone 1 Rattus norvegicus 104-108 6356136-4 1983 Inhibition of norepinephrine synthesis with fusaric acid decreased LHRH content in both oil- and EB-treated rats but had no effect on plasma LH levels. estradiol 3-benzoate 97-99 gonadotropin releasing hormone 1 Rattus norvegicus 67-71 6356136-5 1983 The results suggest that at least a portion of the inhibitory effect of EB on LH release is due to the stimulation of an inhibitory dopaminergic mechanism which reduces LHRH release from the MBH. estradiol 3-benzoate 72-74 gonadotropin releasing hormone 1 Rattus norvegicus 169-173 7040584-8 1982 An s.c. injection of oestradiol benzoate (5 micrograms) increased pituitary responsiveness to LH-RH by the next day in AC rats but decreased serum LH levels in control ovariectomized rats. estradiol 3-benzoate 21-40 gonadotropin releasing hormone 1 Rattus norvegicus 94-99 6993974-3 1980 Furthermore, rats given 50 microgram EB demonstrated cyclic variations in the magnitude of inhibition of LHRH release. estradiol 3-benzoate 37-39 gonadotropin releasing hormone 1 Rattus norvegicus 105-109 3921955-2 1985 Experiments on ovariectomized female rats receiving estradiol benzoate and progesterone showed that i. v. administration of mini LH-RH produced a stimulating effect on the release of gonadotrophins from the hypophysis. estradiol 3-benzoate 52-70 gonadotropin releasing hormone 1 Rattus norvegicus 129-134 3904876-7 1985 Pituitary responsiveness to LHRH (measured as the increase in LH 10 min after iv injections of 100 ng LHRH/rat) was not altered at 60 min but was significantly decreased 180 min following Eb injection. estradiol 3-benzoate 188-190 gonadotropin releasing hormone 1 Rattus norvegicus 28-32 7033996-5 1981 In the same experiment, rats given EB (5 microgram) but not progesterone showed significantly higher scores after the LHRH analog only if they had been designated "responders" by a previous screening test with 1 microgram LHRH. estradiol 3-benzoate 35-37 gonadotropin releasing hormone 1 Rattus norvegicus 118-122 7033996-5 1981 In the same experiment, rats given EB (5 microgram) but not progesterone showed significantly higher scores after the LHRH analog only if they had been designated "responders" by a previous screening test with 1 microgram LHRH. estradiol 3-benzoate 35-37 gonadotropin releasing hormone 1 Rattus norvegicus 222-226 6988205-4 1980 Following a single injection of 5 micrograms of estradiol benzoate (EB), the LHRH concentration of the synaptosomal fraction rose as much as 100% in 27 h. Increasing the dose of EB to 50 micrograms shortened the latency of the rise and prolonged its duration, but did not alter its magnitude compared to the lower dose. estradiol 3-benzoate 68-70 gonadotropin releasing hormone 1 Rattus norvegicus 77-81 6988205-4 1980 Following a single injection of 5 micrograms of estradiol benzoate (EB), the LHRH concentration of the synaptosomal fraction rose as much as 100% in 27 h. Increasing the dose of EB to 50 micrograms shortened the latency of the rise and prolonged its duration, but did not alter its magnitude compared to the lower dose. estradiol 3-benzoate 178-180 gonadotropin releasing hormone 1 Rattus norvegicus 77-81 6995142-12 1980 Ovariectomised female rats, injected twice daily for 3.5 days with 20 microgram of oestradiol benzoate released Gn-RH in response to 50 Hz stimulation in the same amounts as intact control animals. estradiol 3-benzoate 83-102 gonadotropin releasing hormone 1 Rattus norvegicus 112-117 7029491-4 1980 Furthermore, the administration of EB to ovariectomized rats altered the relative sedimentation pattern of LHRH. estradiol 3-benzoate 35-37 gonadotropin releasing hormone 1 Rattus norvegicus 107-111 7029491-6 1980 Peak 1 LHRH was still present and was elevated after EB treatment. estradiol 3-benzoate 53-55 gonadotropin releasing hormone 1 Rattus norvegicus 7-11 7029491-7 1980 Also, EB treatment lowered the free LHRH at the top of the gradient. estradiol 3-benzoate 6-8 gonadotropin releasing hormone 1 Rattus norvegicus 36-40 7029491-8 1980 These data demonstrate that the administration of EB to an ovariectomized rat alters the subcellular distribution of LHRH. estradiol 3-benzoate 50-52 gonadotropin releasing hormone 1 Rattus norvegicus 117-121 386681-2 1979 Anti-LH-RH serum prevented pre-ovulatory gonadotrophin surges at proestrus and ovulation, and it suppressed gonadotrophin increase induced by oestradiol benzoate or progesterone in ovariectomized rats. estradiol 3-benzoate 142-161 gonadotropin releasing hormone 1 Rattus norvegicus 5-10 372239-3 1979 Treatment of castrated rats with either dihydrotestosterone propionate or estradiol benzoate also prevented the decrease in GnRH release from the hypothalami of castrated rats. estradiol 3-benzoate 74-92 gonadotropin releasing hormone 1 Rattus norvegicus 124-128 351123-2 1978 Exposure of pituitary tissue from normal male rats to LH-RH (5 ng/ml for 5 min) induced a small release of LH; in tissue from ovariectomized rats receiving no pretreatment, the release was more than three times greater and in tissue from gonadectomized male or female rats pretreated with oestradiol benzoate and progesterone, the release was six times greater than that observed in normal rats. estradiol 3-benzoate 289-308 gonadotropin releasing hormone 1 Rattus norvegicus 54-59 19713-4 1977 In ovariectomized estradiol benzoate (EB)-treated, androgen-sterilized rats, serum LH concentrations 15 and 60 min after LH-RH injection were lower than in similarly treated control rats. estradiol 3-benzoate 18-36 gonadotropin releasing hormone 1 Rattus norvegicus 121-126 19713-4 1977 In ovariectomized estradiol benzoate (EB)-treated, androgen-sterilized rats, serum LH concentrations 15 and 60 min after LH-RH injection were lower than in similarly treated control rats. estradiol 3-benzoate 38-40 gonadotropin releasing hormone 1 Rattus norvegicus 121-126 789806-5 1976 A similar series of LH-RH infusions given to ovariectomized rats pretreated with oestradiol benzoate during 3 days (the rats were injected daily with 7 mug steroid), produced a highly augmented response of the pituitary gland, but all LH-RH concentrations infused induced rather sharp LH peaks, reaching their maximum after 2-3 h of infusion. estradiol 3-benzoate 81-100 gonadotropin releasing hormone 1 Rattus norvegicus 20-25 789806-5 1976 A similar series of LH-RH infusions given to ovariectomized rats pretreated with oestradiol benzoate during 3 days (the rats were injected daily with 7 mug steroid), produced a highly augmented response of the pituitary gland, but all LH-RH concentrations infused induced rather sharp LH peaks, reaching their maximum after 2-3 h of infusion. estradiol 3-benzoate 81-100 gonadotropin releasing hormone 1 Rattus norvegicus 235-240 789806-7 1976 In both control and oestradiol benzoate-pretreated rats there appeared to be a linear relationship between the logarithm of the blood LH-RH concentration and the maximal plasma LH values on one hand, and the amount of LH secreted during the first 5 h of infusion on the other. estradiol 3-benzoate 20-39 gonadotropin releasing hormone 1 Rattus norvegicus 134-139 780098-9 1976 Serum LHRH concentrations were also significantly reduced in AHD rats following EB injection. estradiol 3-benzoate 80-82 gonadotropin releasing hormone 1 Rattus norvegicus 6-10 768398-8 1976 Pituitary glands from ovariectomized rats treated with 5 mug oestradiol benzoate 24 h before being killed showed an increase in sensitivity to Gn-RH, but the response decreased when oestrogen was injected 2 h before death. estradiol 3-benzoate 61-80 gonadotropin releasing hormone 1 Rattus norvegicus 143-148 1108288-6 1975 An injection of 2 ng of synthetic LH-RH into the pituitary following 0.1 mug of estradiol benzoate resulted in a fall of serum LH and FSH levels, and a rise of serum prolactin level. estradiol 3-benzoate 80-98 gonadotropin releasing hormone 1 Rattus norvegicus 34-39 1100362-6 1975 Pretreatment with EB resulted in increased serum LH after LHRH injection in young estrous and diestrous rats and in aged constant estrous rats, but did not alter serum LH levels in the aged pseudopregnant rats. estradiol 3-benzoate 18-20 gonadotropin releasing hormone 1 Rattus norvegicus 58-62 343823-0 1978 Direct effects of estradiol benzoate and testosterone on the response of the male rat pituitary to luteinizing hormone releasing hormone (LHRH). estradiol 3-benzoate 18-36 gonadotropin releasing hormone 1 Rattus norvegicus 99-136 343823-0 1978 Direct effects of estradiol benzoate and testosterone on the response of the male rat pituitary to luteinizing hormone releasing hormone (LHRH). estradiol 3-benzoate 18-36 gonadotropin releasing hormone 1 Rattus norvegicus 138-142 1091117-11 1975 In oophorectomized rats whose pituitaries had been blocked with oestradiol monobenzoate and progesterone, a linear log-dose response of plasma LH was found after administration of various doses of synthetic LH-RH. estradiol 3-benzoate 64-87 gonadotropin releasing hormone 1 Rattus norvegicus 207-212 1093195-7 1975 Estradiol benzoate depressed the basal serum GSH level and augmented the basal serum GSH level and augmented LH release after intermittent infusion with LH-RH, indicating that estrogen modified FSH/LH ratio. estradiol 3-benzoate 0-18 gonadotropin releasing hormone 1 Rattus norvegicus 153-158 4607938-0 1974 The effect of estradiol benzoate on the pituitary responsiveness to LH-RH in male and female rats. estradiol 3-benzoate 14-32 gonadotropin releasing hormone 1 Rattus norvegicus 68-73 26667127-9 2016 To further explore the relationship between spines on GnRH neurons and pubertal development, we next analyzed adult rats neonatally exposed to estradiol benzoate, in which puberty onset and reproductive functions are disrupted. estradiol 3-benzoate 143-161 gonadotropin releasing hormone 1 Rattus norvegicus 54-58 30920587-7 2019 Because LH secretory responses to kisspeptin challenge and GnRH expression were spared in male rats with the EB treatment, LH pulse suppression is most probably due to ARC KNDy deficiency. estradiol 3-benzoate 109-111 gonadotropin releasing hormone 1 Rattus norvegicus 59-63 17888527-1 2008 The present study was designed to assess the participation of gonadotropin-releasing hormone (GnRH) in the display of estrous behavior induced by application of vaginal-cervical stimulation (VCS) and by the intracerebroventricular (icv) administration of progesterone and its ring A-reduced metabolites to ovariectomized (ovx), estradiol benzoate (E2B) primed rats. estradiol 3-benzoate 328-346 gonadotropin releasing hormone 1 Rattus norvegicus 62-92 17888527-1 2008 The present study was designed to assess the participation of gonadotropin-releasing hormone (GnRH) in the display of estrous behavior induced by application of vaginal-cervical stimulation (VCS) and by the intracerebroventricular (icv) administration of progesterone and its ring A-reduced metabolites to ovariectomized (ovx), estradiol benzoate (E2B) primed rats. estradiol 3-benzoate 328-346 gonadotropin releasing hormone 1 Rattus norvegicus 94-98