PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23723562-6 2013 The positive index of ERalpha in the EB-treated group increased when compared with that of the naive group. estradiol 3-benzoate 37-39 estrogen receptor 1 Rattus norvegicus 22-29 19596275-3 2009 The present study generated a profile of synaptic proteins altered by administration of estradiol benzoate, the ERalpha selective agonist PPT (1,3,5-tris (4-hydroxyphenyl)-4-propyl-1H-pyrazole) and the ERbeta selective agonist DPN (2,3-bis (4-hydroxyphenyl) propionitrile) alone and in combination in comparison to vehicle in the CA1 region of the dorsal hippocampus. estradiol 3-benzoate 88-106 estrogen receptor 1 Rattus norvegicus 112-119 22016562-9 2011 EB-treated rats had significantly higher percentage of methylation at three CpG sites in the Esr1 promoter compared with control rats. estradiol 3-benzoate 0-2 estrogen receptor 1 Rattus norvegicus 93-97 19646508-8 2009 As the results, in EB-treated rats, the density of ERalpha-ir cells in all regions, except the male AVPvN and male lMCG, were lower than those in untreated rats of both sexes. estradiol 3-benzoate 19-21 estrogen receptor 1 Rattus norvegicus 51-58 18950659-4 2009 Sexual receptivity, as ascertained by the lordosis quotient, was unaffected by either PPT or DPN treatment but nearly abolished by estradiol benzoate (EB), a synthetic estrogen with high affinity for both ERalpha and ERbeta. estradiol 3-benzoate 131-149 estrogen receptor 1 Rattus norvegicus 205-212 18950659-4 2009 Sexual receptivity, as ascertained by the lordosis quotient, was unaffected by either PPT or DPN treatment but nearly abolished by estradiol benzoate (EB), a synthetic estrogen with high affinity for both ERalpha and ERbeta. estradiol 3-benzoate 151-153 estrogen receptor 1 Rattus norvegicus 205-212 18757761-7 2008 Pharmacological experiments demonstrated that the single injection of estradiol benzoate had a significant effect on the ERalpha-ir cell count, suggesting the hormonal responsiveness of SGN neurons. estradiol 3-benzoate 70-88 estrogen receptor 1 Rattus norvegicus 121-128 11500981-6 2001 The expression of the estrogen mediator, estrogen receptor-alpha (ER-alpha), diminished specifically in theca cells at P6 and recovered by P14 in the EB-treated ovary. estradiol 3-benzoate 150-152 estrogen receptor 1 Rattus norvegicus 66-74 15778002-3 2005 Estrogen receptor-alpha (ER-alpha) decreased within 2 h of genistein or EB treatment, returning to basal levels within 24 and 48 h, respectively. estradiol 3-benzoate 72-74 estrogen receptor 1 Rattus norvegicus 25-33 15375486-11 2004 At 5 weeks after carcinogen treatment, there were increased branchings of the mammary gland, and there was also a decrease of ERalpha and ERbeta in EB treatment groups. estradiol 3-benzoate 148-150 estrogen receptor 1 Rattus norvegicus 126-133 8856721-2 1996 The number of ER immunoreactive (ER-IR) cells decreased and expression of ER mRNA was suppressed in the arcuate (ARH) and the ventromedial (VMH) hypothalamic nuclei by daily injections of estradiol benzoate (EB) for ten consecutive days. estradiol 3-benzoate 188-206 estrogen receptor 1 Rattus norvegicus 14-16 11174013-12 2001 In adult (75-day-old) males, EB administration (25 microg/rat) induced a significant time-dependent decrease in pituitary ERalpha and ERbeta mRNA levels. estradiol 3-benzoate 29-31 estrogen receptor 1 Rattus norvegicus 122-129 9492057-7 1998 ER alpha mRNA levels were low in EB treated animals, elevated in T4 or oil-treated animals and further elevated in EB + T4-treated animals. estradiol 3-benzoate 33-35 estrogen receptor 1 Rattus norvegicus 0-8 9492057-7 1998 ER alpha mRNA levels were low in EB treated animals, elevated in T4 or oil-treated animals and further elevated in EB + T4-treated animals. estradiol 3-benzoate 115-117 estrogen receptor 1 Rattus norvegicus 0-8 9353572-0 1997 Biological properties of conjugates of mitomycin C with estradiol benzoate and estradiol: their stability characteristics in biological media and their binding abilities to estrogen receptor. estradiol 3-benzoate 56-74 estrogen receptor 1 Rattus norvegicus 173-190 9112371-4 1997 Exposure to estradiol benzoate on days 1, 3, and 5 resulted in induction of ER expression in periductal smooth muscle cells from the proximal regions out to the distal tips of the developing prostate lobes. estradiol 3-benzoate 12-30 estrogen receptor 1 Rattus norvegicus 76-78 8856721-2 1996 The number of ER immunoreactive (ER-IR) cells decreased and expression of ER mRNA was suppressed in the arcuate (ARH) and the ventromedial (VMH) hypothalamic nuclei by daily injections of estradiol benzoate (EB) for ten consecutive days. estradiol 3-benzoate 188-206 estrogen receptor 1 Rattus norvegicus 33-35 8856721-2 1996 The number of ER immunoreactive (ER-IR) cells decreased and expression of ER mRNA was suppressed in the arcuate (ARH) and the ventromedial (VMH) hypothalamic nuclei by daily injections of estradiol benzoate (EB) for ten consecutive days. estradiol 3-benzoate 188-206 estrogen receptor 1 Rattus norvegicus 33-35 8856721-3 1996 In contrast, in the POA, expression of ER mRNA was not suppressed by EB treatment, while the ER immunoreactivity and the number of ER-IR cells was decreased by EB treatment. estradiol 3-benzoate 160-162 estrogen receptor 1 Rattus norvegicus 39-41 8856721-3 1996 In contrast, in the POA, expression of ER mRNA was not suppressed by EB treatment, while the ER immunoreactivity and the number of ER-IR cells was decreased by EB treatment. estradiol 3-benzoate 160-162 estrogen receptor 1 Rattus norvegicus 93-95 8856721-3 1996 In contrast, in the POA, expression of ER mRNA was not suppressed by EB treatment, while the ER immunoreactivity and the number of ER-IR cells was decreased by EB treatment. estradiol 3-benzoate 160-162 estrogen receptor 1 Rattus norvegicus 93-95 19215395-8 1990 ER mRNA levels fell 42% (ventromedial), 64% (arcuate), or remained unchanged (dorsomedial) 18 h following estradiol benzoate treatment. estradiol 3-benzoate 106-124 estrogen receptor 1 Rattus norvegicus 0-2 7925135-5 1994 Double-labeling histochemistry revealed that more than 70% of the NADPH-d positive neurons contained ER-ir in the VMN of all groups, with EB-treated females having a significantly higher frequency than all other groups. estradiol 3-benzoate 138-140 estrogen receptor 1 Rattus norvegicus 101-103 8653398-3 1995 ER molecules were measured by immunohistochemistry and in situ hybridization histochemistry after daily injections of testosterone propionate (TP; 100 micrograms/0.02 ml) and estradiol benzoate (EB; 10 micrograms/0.02 ml) in the male pups castrated within 24 h of birth. estradiol 3-benzoate 175-193 estrogen receptor 1 Rattus norvegicus 0-2 8653398-3 1995 ER molecules were measured by immunohistochemistry and in situ hybridization histochemistry after daily injections of testosterone propionate (TP; 100 micrograms/0.02 ml) and estradiol benzoate (EB; 10 micrograms/0.02 ml) in the male pups castrated within 24 h of birth. estradiol 3-benzoate 195-197 estrogen receptor 1 Rattus norvegicus 0-2 23825124-9 2013 In experiment II, compared with oil controls, total ARH ERalpha protein was decreased 48 hours after 50 mug EB, but the 2 mug dose was not. estradiol 3-benzoate 108-110 estrogen receptor 1 Rattus norvegicus 56-63 12934-1 1977 We tested the hypothesis that neonatal treatment of rats with testosterone propionate (TP) or estradiol benzoate (EB) reduces the uterine responsiveness to estradiol and reduces the concentration of estrogen "receptor" before puberty, and that both of these events precede the onset of the persistent estrus syndrome. estradiol 3-benzoate 94-112 estrogen receptor 1 Rattus norvegicus 199-217 12934-1 1977 We tested the hypothesis that neonatal treatment of rats with testosterone propionate (TP) or estradiol benzoate (EB) reduces the uterine responsiveness to estradiol and reduces the concentration of estrogen "receptor" before puberty, and that both of these events precede the onset of the persistent estrus syndrome. estradiol 3-benzoate 114-116 estrogen receptor 1 Rattus norvegicus 199-217 12934-5 1977 At 23 and 31 days of age the uterine cytoplasmic 8S estrogen "receptor" was significantly reduced in the EB-treated rats, but the uterotropic response to estradiol was blocked only in the 23 day old rats; the uterine response at 31 days was slightly, but not significantly, reduced. estradiol 3-benzoate 105-107 estrogen receptor 1 Rattus norvegicus 52-70 28063803-2 2017 In the estradiol benzoate (EB) primed ovariectomized (OVX) rat, EB initially binds to ERalpha in the plasma membrane that complexes with and transactivates metabotropic glutamate receptor 1a to activate beta-endorphin neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN). estradiol 3-benzoate 7-25 estrogen receptor 1 Rattus norvegicus 86-93 28063803-2 2017 In the estradiol benzoate (EB) primed ovariectomized (OVX) rat, EB initially binds to ERalpha in the plasma membrane that complexes with and transactivates metabotropic glutamate receptor 1a to activate beta-endorphin neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN). estradiol 3-benzoate 27-29 estrogen receptor 1 Rattus norvegicus 86-93 26384964-4 2015 We have addressed this subject in the current investigation by estimating, using stereological tools, the total number of MPN neurons that express ERalpha in rats at each phase of the estrous cycle and in ovariectomized rats treated with estradiol benzoate (EB), P or the ERalpha- and estrogen receptor beta (ERbeta)-specific agonists. estradiol 3-benzoate 238-256 estrogen receptor 1 Rattus norvegicus 147-154 23825124-10 2013 These results indicate that both EB doses reduced the total number of cells expressing ERalpha, but 2 mug EB may have maintained or increased ERalpha expressed per cell, whereas 50 mug EB appeared to reduce total ERalpha per cell. estradiol 3-benzoate 33-35 estrogen receptor 1 Rattus norvegicus 87-94