PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21946955-4 2012 A total amount of 10 micromol/l of biochanin A or genistein significantly suppressed the secretion of tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) in LPS-induced RAW264.7 cells, whereas another two isoflavones, formononectin and daidzein, only significantly suppressed the secretion of IL-6. daidzein 248-256 tumor necrosis factor Mus musculus 102-129 30806288-8 2019 Furthermore, oral administration of DA decreased the level of myeloperoxidase (MPO) and inhibited the expression of p65-NF-kappaB, p-IkappaB-alpha, and p-IKK as well as several inflammatory factors, including TNF-alpha, IL-1beta, and IL-6, in the colonic tissues. daidzein 36-38 tumor necrosis factor Mus musculus 209-218 28545670-11 2017 The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG. daidzein 142-150 tumor necrosis factor Mus musculus 42-51 28545670-12 2017 Regarding protein levels, IFN-alpha was significantly induced in cells pre-treated with fisetin, quercetin, and daidzein, whereas TNF-alpha was significantly induced only in cells pre-treated with daidzein. daidzein 197-205 tumor necrosis factor Mus musculus 130-139 27222119-5 2016 Daidzein had an anti-inflammatory effect by inhibiting tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and nuclear factor kappaB (NF-kappaB) protein expression. daidzein 0-8 tumor necrosis factor Mus musculus 55-82 27222119-5 2016 Daidzein had an anti-inflammatory effect by inhibiting tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and nuclear factor kappaB (NF-kappaB) protein expression. daidzein 0-8 tumor necrosis factor Mus musculus 84-93 34850494-9 2022 Administering daidzein significantly restored the functional levels of dopamine and pro-inflammatory mediators TNF-alpha, IL-1beta, IL6 to near normal physiology as seen in healthy C57BL6 mice controls. daidzein 14-22 tumor necrosis factor Mus musculus 111-120 28831294-10 2017 Daidzein attenuated cisplatin-induced inflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin 10 (IL-10), interleukin 18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1). daidzein 0-8 tumor necrosis factor Mus musculus 61-88 28831294-10 2017 Daidzein attenuated cisplatin-induced inflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin 10 (IL-10), interleukin 18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1). daidzein 0-8 tumor necrosis factor Mus musculus 90-98 27465724-2 2016 We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent TNF-alpha-induced muscle atrophy in C2C12 myotubes. daidzein 72-80 tumor necrosis factor Mus musculus 90-99 25908100-5 2015 Daidzein decreased the bacterial load in peritoneal fluid, blood, and lungs, reduced the tumor necrosis factor alpha and nitrite level in plasma, and partially suppressed lung injury by reducing vascular permeability and myeloperoxidase activity in septic mice. daidzein 0-8 tumor necrosis factor Mus musculus 89-116 24632845-0 2014 Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-alpha-stimulated murine lung epithelial cells via depressing PARP-1 activity. daidzein 0-8 tumor necrosis factor Mus musculus 70-79 24632845-8 2014 RESULTS: Pretreatment of the mice with daidzein markedly attenuated TNF-alpha-induced lung inflammation, and inhibited Cxcl2 expression in lung tissues. daidzein 39-47 tumor necrosis factor Mus musculus 68-77 24632845-9 2014 Furthermore, daidzein (10 mumol/L) prevented TNF-alpha-induced increases in Cxcl2 expression and activity and NF-kappaB transcriptional activity, and markedly inhibited TNF-alpha-induced protein PARylation in MLE-12 cells in vitro. daidzein 13-21 tumor necrosis factor Mus musculus 45-54 24632845-9 2014 Furthermore, daidzein (10 mumol/L) prevented TNF-alpha-induced increases in Cxcl2 expression and activity and NF-kappaB transcriptional activity, and markedly inhibited TNF-alpha-induced protein PARylation in MLE-12 cells in vitro. daidzein 13-21 tumor necrosis factor Mus musculus 169-178 24632845-10 2014 In MLE-12 cells co-transfected with the PARP-1 expression plasmid and NF-kappaB-luc (or Cxcl2-luc) reporter plasmid, TNF-alpha markedly increased NF-kappaB (or Cxcl2) activation, which were significantly attenuated in the presence of daidzein (or the protein PARylation inhibitor PJ 34). daidzein 234-242 tumor necrosis factor Mus musculus 117-126 22125674-0 2011 Comparative effect of genistein and daidzein on the expression of MCP-1, eNOS, and cell adhesion molecules in TNF-alpha-stimulated HUVECs. daidzein 36-44 tumor necrosis factor Mus musculus 110-119 22125674-6 2011 Pre-treatment with either genistein or daidzein elevated eNOS expression and nitric oxide production disturbed by TNF-alpha exposure. daidzein 39-47 tumor necrosis factor Mus musculus 114-123 21268069-2 2011 The phytoestrogens genistein, daidzein, and coumestrol directly suppressed TNF-alpha-induced osteoclastogenesis and bone resorption. daidzein 30-38 tumor necrosis factor Mus musculus 75-84 21731677-5 2011 This study explores the effect of daidzein (Daid) on the proliferation of TNF-alpha producing T cells, premature senescent T cells and B cell lymphopoesis under estrogen deficient conditions. daidzein 34-42 tumor necrosis factor Mus musculus 74-83 17849275-3 2007 Therefore, we examined the effects of individual isoflavones (daidzein, daidzin, genistein, and genistin) on the LPS-induced production of TNF-alpha. daidzein 62-70 tumor necrosis factor Mus musculus 139-148 17849275-4 2007 Intraperitoneal injections of daidzein, daidzin, and genistin (but not of genistein before a challenge with LPS) resulted in significant depression of serum levels of TNF-alpha in mice. daidzein 30-38 tumor necrosis factor Mus musculus 167-176 11473722-13 2001 It is suggested that both genistein and daidzein have an inhibitory effect on estrogen-related endometrial carcinogenesis in mice, possibly by suppressing expression of estrogen-induced estrogen-related genes c-fos and c-jun, and internal cytokines IL-1alpha and TNF-alpha through a cytokine and estrogen receptor-mediated pathway. daidzein 40-48 tumor necrosis factor Mus musculus 263-272