PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34630655-3	2021	The results of the present study indicated that daidzein significantly inhibited the production of IL-6, but not IL-8.	daidzein	48-56	interleukin 6	Homo sapiens	99-103	
12094620-7	2001	In addition, interleukin-6 synthesis by these two cell lines was inhibited by genistein or daidzein; production was decreased by approximately 20% compared with the control group (P < 0.05).	daidzein	91-99	interleukin 6	Homo sapiens	13-26	
34630655-5	2021	To elucidate the molecular mechanisms underlying the daidzein-mediated inhibition of IL-6 production, the present study examined the effects of daidzein on the phosphorylation (activation) of NF-kappaB p65, ERK1/2 and p38 MAPK.	daidzein	53-61	interleukin 6	Homo sapiens	85-89	
34630655-5	2021	To elucidate the molecular mechanisms underlying the daidzein-mediated inhibition of IL-6 production, the present study examined the effects of daidzein on the phosphorylation (activation) of NF-kappaB p65, ERK1/2 and p38 MAPK.	daidzein	144-152	interleukin 6	Homo sapiens	85-89	
34630655-7	2021	The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation.	daidzein	75-83	interleukin 6	Homo sapiens	148-152	
34630655-7	2021	The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation.	daidzein	111-119	interleukin 6	Homo sapiens	148-152	
34630655-8	2021	Collectively, these results suggested that daidzein may have potential as a therapeutic agent for the treatment of arthritic disorders through its anti-inflammatory effects via the inhibition of IL-6 production.	daidzein	43-51	interleukin 6	Homo sapiens	195-199	
21945492-9	2011	Daidzein also suppressed pro-inflammatory cytokine production such as IL-12p40, IL-6 and TNF-alpha, whereas it didn"t affect IL-10 and IL-1beta expression.	daidzein	0-8	interleukin 6	Homo sapiens	80-84	
32712091-7	2020	In addition, the expression of inflammatory factors, including interleukin-1beta (IL-lbeta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were decreased by 100 muM daidzein (73.8% +- 5.3%, 58.8 +- 9.0% and 55.5% +- 7.2%, respectively) in LPS-treated hepatocytes.	daidzein	184-192	interleukin 6	Homo sapiens	93-106	
32712091-7	2020	In addition, the expression of inflammatory factors, including interleukin-1beta (IL-lbeta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were decreased by 100 muM daidzein (73.8% +- 5.3%, 58.8 +- 9.0% and 55.5% +- 7.2%, respectively) in LPS-treated hepatocytes.	daidzein	184-192	interleukin 6	Homo sapiens	108-112	
27576059-3	2016	In our study, we studied the effects of daidzein, raloxifene and E2 on expression of the osteoblast-produced bone regulatory factors OPG, RANKL and IL-6 in human osteoblastic MG-63 cells.	daidzein	40-48	interleukin 6	Homo sapiens	148-152	
27576059-4	2016	Results suggest that treatment with daidzein, raloxifene and E2 increased the levels of OPG and decreased those of RANKL and IL-6.	daidzein	36-44	interleukin 6	Homo sapiens	125-129	
26901838-6	2016	Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture.	daidzein	0-8	interleukin 6	Homo sapiens	138-151	
26901838-6	2016	Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture.	daidzein	0-8	interleukin 6	Homo sapiens	153-156	
26901838-8	2016	Daidzein also decreased Ccl2 and Il6 mRNA levels in RAW264 macrophages stimulated with palmitate or conditioned medium (CM) from hypertrophied 3T3-L1 adipocytes.	daidzein	0-8	interleukin 6	Homo sapiens	33-36	
16491457-4	2006	Coumestrol, daidzein and genistein stimulate the expression of the ERE-dependent reporter in MVLN cells and repress the activity of the IL-6 promoter in U2OS cells in a dose-dependent manner.	daidzein	12-20	interleukin 6	Homo sapiens	136-140	
16651441-1	2006	We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression.	daidzein	69-77	interleukin 6	Homo sapiens	146-159	
16651441-1	2006	We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression.	daidzein	69-77	interleukin 6	Homo sapiens	161-164