PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14664520-2 2003 Here, we investigated the effects of some dietary phytoestrogens such as the isoflavones genistein and daidzein, its metabolite equol, and the coumestane coumestrol on the binding rate of ERalpha and ERbeta to ERE by a nonradioactive real-time method, the Biacore Technology. daidzein 103-111 estrogen receptor 1 Homo sapiens 188-195 15040033-0 2004 Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro. daidzein 11-19 estrogen receptor 1 Homo sapiens 23-40 14664520-10 2003 The endogenous hormone 17beta-estradiol as well as coumestrol and daidzein metabolite equol activate the binding of ERbeta to ERE only slightly more effectively than the binding of ERalpha to ERE. daidzein 66-74 estrogen receptor 1 Homo sapiens 181-188 28633868-6 2017 The above actions of daidzein were prevented by cotreatment with the ER antagonist ICI 182780. daidzein 21-29 estrogen receptor 1 Homo sapiens 69-71 12894229-4 2003 Indeed, the phyto-oestrogens, genistein and daidzein, act as weak agonists of the oestrogenic activity via ERalpha, but as full agonists when bound to ERbeta. daidzein 44-52 estrogen receptor 1 Homo sapiens 107-114 12609556-2 2003 Soy contains genistein and daidzein, two phytoestrogens, which work through the estrogen receptor and cause alterations in serum lipids, bone metabolism, and possibly cognition. daidzein 27-35 estrogen receptor 1 Homo sapiens 80-97 11017892-4 2000 We used fluorescence polarization to measure the binding affinities of genistein, coumestrol, daidzein, glyceollin, and zearalenone for human ER[alpha] and ERss. daidzein 94-102 estrogen receptor 1 Homo sapiens 142-150 34539970-2 2021 The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. daidzein 28-36 estrogen receptor 1 Homo sapiens 173-190 34539970-2 2021 The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. daidzein 28-36 estrogen receptor 1 Homo sapiens 192-194 34539970-4 2021 However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. daidzein 9-17 estrogen receptor 1 Homo sapiens 33-35 32040188-5 2020 The most obvious activity identified was the estrogen receptor (ER)-mediated actions of the chemical group containing parabens and structurally related gallates, as well the chemical group containing genistein and daidzein (the latter particularly towards ERbeta as potential health beneficial target). daidzein 214-222 estrogen receptor 1 Homo sapiens 256-262 29051735-1 2017 The beneficial effect of dietary soy food intake, especially for women diagnosed with breast cancer, is controversial, as in vitro data has shown that the soy isoflavones genistein and daidzein may even stimulate the proliferation of estrogen-receptor alpha positive (ERalpha+) breast cancer cells at low concentrations. daidzein 185-193 estrogen receptor 1 Homo sapiens 234-257 29051735-1 2017 The beneficial effect of dietary soy food intake, especially for women diagnosed with breast cancer, is controversial, as in vitro data has shown that the soy isoflavones genistein and daidzein may even stimulate the proliferation of estrogen-receptor alpha positive (ERalpha+) breast cancer cells at low concentrations. daidzein 185-193 estrogen receptor 1 Homo sapiens 268-275 28633868-0 2017 Daidzein stimulates osteogenesis facilitating proliferation, differentiation, and antiapoptosis in human osteoblast-like MG-63 cells via estrogen receptor-dependent MEK/ERK and PI3K/Akt activation. daidzein 0-8 estrogen receptor 1 Homo sapiens 137-154 28633868-3 2017 We hypothesized that daidzein stimulates osteogenesis through estrogen receptor (ER)-dependent signal pathways. daidzein 21-29 estrogen receptor 1 Homo sapiens 62-79 28633868-3 2017 We hypothesized that daidzein stimulates osteogenesis through estrogen receptor (ER)-dependent signal pathways. daidzein 21-29 estrogen receptor 1 Homo sapiens 81-83 12094620-10 2001 In summary, genistein and daidzein independently modify cytokine production and reduce ovarian cancer cell proliferation via, at least in part, an estrogen receptor-dependent pathway. daidzein 26-34 estrogen receptor 1 Homo sapiens 147-164 33639680-0 2021 Daidzein Induces Intrinsic Pathway of Apoptosis along with ER alpha/beta Ratio Alteration and ROS Production. daidzein 0-8 estrogen receptor 1 Homo sapiens 59-72 33639680-14 2021 CONCLUSIONS: In conclusion, the present study suggests that Daidzein induces apoptosis in MCF-7 cells by mitochondrial pathway along with lowering the ratio of ER alpha/beta and an outburst of Reactive Oxygen Species(ROS). daidzein 60-68 estrogen receptor 1 Homo sapiens 160-173 30889096-1 2019 OBJECTIVE: PhytoSERM is a formulation of genistein, daidzein, and S-equol that has an 83-fold selective affinity for estrogen receptor-beta (ERbeta); and may enhance neuron function and estrogenic mechanisms in the brain without having peripheral estrogenic activity. daidzein 52-60 estrogen receptor 1 Homo sapiens 117-139 30889096-1 2019 OBJECTIVE: PhytoSERM is a formulation of genistein, daidzein, and S-equol that has an 83-fold selective affinity for estrogen receptor-beta (ERbeta); and may enhance neuron function and estrogenic mechanisms in the brain without having peripheral estrogenic activity. daidzein 52-60 estrogen receptor 1 Homo sapiens 141-147 28633868-10 2017 Taken together, the results indicate that daidzein stimulates osteogenesis through facilitating proliferation, differentiation, and antiapoptosis in human osteoblast-like MG-63 cells via activation of MEK/ERK and PI3K/Akt in an ER-dependent manner. daidzein 42-50 estrogen receptor 1 Homo sapiens 205-207 27576059-6 2016 Moreover, daidzein may promote activation of the classic estrogen response element (ERE) pathway through increasing ERalpha, ERbeta and steroid hormone receptor coactivator (SRC)-1 expression. daidzein 10-18 estrogen receptor 1 Homo sapiens 116-123 23337939-0 2013 Antiproliferative activity of daidzein and genistein may be related to ERalpha/c-erbB-2 expression in human breast cancer cells. daidzein 30-38 estrogen receptor 1 Homo sapiens 83-90 26361015-6 2015 Glucuronidation changed the preferential activation of genistein from ERbeta-LBD to ERalpha-LBD and further increased the slightly preferential activation of daidzein for ERalpha-LBD. daidzein 158-166 estrogen receptor 1 Homo sapiens 171-178 26361015-8 2015 Our results show that genistein and daidzein remain agonistic ligands of ERalpha-LBD and ERbeta-LBD in their conjugated form with a higher relative preference for ERalpha-LBD than the corresponding aglycones. daidzein 36-44 estrogen receptor 1 Homo sapiens 73-80 26361015-8 2015 Our results show that genistein and daidzein remain agonistic ligands of ERalpha-LBD and ERbeta-LBD in their conjugated form with a higher relative preference for ERalpha-LBD than the corresponding aglycones. daidzein 36-44 estrogen receptor 1 Homo sapiens 163-170 25168698-0 2014 Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms. daidzein 6-14 estrogen receptor 1 Homo sapiens 144-161 25168698-14 2014 Furthermore, the patterns of gene induction differed following treatment with each daidzein analog, suggesting that these daidzein analogs activate distinct ER and non-ER pathways to induce differentiation in BMSCs and ASCs. daidzein 83-91 estrogen receptor 1 Homo sapiens 157-159 25168698-14 2014 Furthermore, the patterns of gene induction differed following treatment with each daidzein analog, suggesting that these daidzein analogs activate distinct ER and non-ER pathways to induce differentiation in BMSCs and ASCs. daidzein 83-91 estrogen receptor 1 Homo sapiens 168-170 25168698-14 2014 Furthermore, the patterns of gene induction differed following treatment with each daidzein analog, suggesting that these daidzein analogs activate distinct ER and non-ER pathways to induce differentiation in BMSCs and ASCs. daidzein 122-130 estrogen receptor 1 Homo sapiens 157-159 25168698-14 2014 Furthermore, the patterns of gene induction differed following treatment with each daidzein analog, suggesting that these daidzein analogs activate distinct ER and non-ER pathways to induce differentiation in BMSCs and ASCs. daidzein 122-130 estrogen receptor 1 Homo sapiens 168-170 24724627-3 2014 Daidzein inhibited TNF-alpha induced cellular migration and invasion in estrogen receptor (ER) negative MCF10DCIS.com human breast cancer cells. daidzein 0-8 estrogen receptor 1 Homo sapiens 72-89 24724627-3 2014 Daidzein inhibited TNF-alpha induced cellular migration and invasion in estrogen receptor (ER) negative MCF10DCIS.com human breast cancer cells. daidzein 0-8 estrogen receptor 1 Homo sapiens 91-93 23384675-10 2013 Daidzein, genistein, kaempferol, and coumestrol (group 2) activated both ERalpha and ERbeta ERE-mediated activities. daidzein 0-8 estrogen receptor 1 Homo sapiens 73-80 23337939-2 2013 After treatment at various concentrations (1-200 microM for 72 h), the effect of daidzein and genistein on the proliferation of different cell types varied; these effects were found to be associated with ERalpha and c-erbB-2 expression. daidzein 93-101 estrogen receptor 1 Homo sapiens 240-247 23337939-3 2013 Daidzein and genistein exhibited biphasic effects (stimulatory or inhibitory) on proliferation and ERalpha expression in MCF-7 cells. daidzein 0-8 estrogen receptor 1 Homo sapiens 111-118 23337939-10 2013 In conclusion, the isoflavones daidzein and genistein showed anti-breast cancer activity, which was associated with expression of the ERalpha and c-erbB-2 receptors. daidzein 43-51 estrogen receptor 1 Homo sapiens 158-165 21056929-8 2011 The inhibitory effects of E(2), genistein and daidzein on CRE-mediated transcription activity were enhanced by estrogen receptor (ER) alpha overexpression in MG-63 cells, which could be blocked by nonselective ER antagonists ICI182780, 4-OH tamoxifen and specific ERalpha antagonist MPP. daidzein 46-54 estrogen receptor 1 Homo sapiens 111-139 21056929-8 2011 The inhibitory effects of E(2), genistein and daidzein on CRE-mediated transcription activity were enhanced by estrogen receptor (ER) alpha overexpression in MG-63 cells, which could be blocked by nonselective ER antagonists ICI182780, 4-OH tamoxifen and specific ERalpha antagonist MPP. daidzein 46-54 estrogen receptor 1 Homo sapiens 264-271 22091435-0 2011 Prepubertal daidzein exposure enhances mammary gland differentiation and regulates the expression of estrogen receptor-alpha and apoptotic proteins. daidzein 12-20 estrogen receptor 1 Homo sapiens 101-124 22091435-5 2011 There was a significant decrease of ER-alpha expression at PND21 and increase in its expression at PND50, in daidzein-treated animals. daidzein 109-117 estrogen receptor 1 Homo sapiens 36-44 22091435-1 2011 Mechanism of chemoprevention by daidzein (500 mug/g bwt) was examined by injecting it subcutaneously at 16th, 18th, and 20th day postpartum, followed by counting of terminal end buds (TEBs), terminal ducts (TDs), and lobules and immunohistochemistry of ER-alpha, Bcl2, Bax, and caspase-3. daidzein 32-40 estrogen receptor 1 Homo sapiens 253-261 20669983-6 2010 These results demonstrated the structural requirements for the transformation of daidzein from an ER agonist to an antagonist. daidzein 81-89 estrogen receptor 1 Homo sapiens 98-100 16118406-6 2005 Purified genistein, daidzein, apigenin, and coumestrol showed differential and robust transactivation of ERalpha- and ERbeta-induced transcription, with an up to 100-fold stronger activation of ERbeta. daidzein 20-28 estrogen receptor 1 Homo sapiens 105-112 19434885-2 2008 Soy contains genistein and daidzein, two phytoestrogens, which work through the estrogen receptor and cause alterations in serum lipids, bone metabolism, and possibly cognition. daidzein 27-35 estrogen receptor 1 Homo sapiens 80-97 16884174-1 2006 The soy isoflavones genistein and daidzein, as well as the daidzein metabolite equol, have structural similarities to mammalian estrogens and bind with varying affinity to both known subtypes of the estrogen receptor. daidzein 34-42 estrogen receptor 1 Homo sapiens 199-216 16884174-1 2006 The soy isoflavones genistein and daidzein, as well as the daidzein metabolite equol, have structural similarities to mammalian estrogens and bind with varying affinity to both known subtypes of the estrogen receptor. daidzein 59-67 estrogen receptor 1 Homo sapiens 199-216 16506809-7 2006 The IC(50) values for the ERalpha and ERbeta binding assays were 0.4 and 0.75 microM for urolithin A; 20 and 11 microM for urolithin B; 3 and 0.02 for genistein; and 2.3 and 1 for daidzein, respectively; no binding was detected for resveratrol and enterolactone. daidzein 180-188 estrogen receptor 1 Homo sapiens 26-33 19182375-5 2009 As a result, coumestrol and genistein strongly activated ERalpha and ERbeta at very low concentrations of <1x10(-10) M. Most phytochemicals showing estrogenic activity also exhibited agonistic activity against ERbeta at lower concentrations than those for ERalpha, and two typical isoflavones, genistein and daidzein, in particular, showed a potent preference for ERbeta. daidzein 311-319 estrogen receptor 1 Homo sapiens 57-64 16033089-8 2005 RESULTS: Endometrial glandular cells responded to stimulation with genistein and daidzein by alteration of both ERalpha- and ERbeta-mRNA expression. daidzein 81-89 estrogen receptor 1 Homo sapiens 112-119 15668497-5 2005 Adjusting for age and body mass index, urinary daidzein, genistein, glycitein, and serum daidzein and glycitein were negatively correlated with plasma estradiol (R = -0.199 to -0.277, P <0.03), with particularly strong associations found in the 18 women with CC genotype for ESR1 PvuII polymorphism (R = -0.597 to -0.834, P < 0.03). daidzein 89-97 estrogen receptor 1 Homo sapiens 278-282