PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17477369-11	2007	Pharmacodynamic studies showed an increase in expression of p21 and decrease in PCNA in xenografts of VPA-treated mice compared with protein expression in untreated controls.	Valproic Acid	102-105	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	60-63	
17760752-7	2007	Our result showed that chronic administration of VPA has an effect on tumor growth arrest and the effect was associated with increased histone acetylation, p21CIP1/WAF1 up-regulation, and VEGF down-regulation.	Valproic Acid	49-52	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	156-163	
17760752-7	2007	Our result showed that chronic administration of VPA has an effect on tumor growth arrest and the effect was associated with increased histone acetylation, p21CIP1/WAF1 up-regulation, and VEGF down-regulation.	Valproic Acid	49-52	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	164-168	
29312803-4	2017	Co-treatment of sorafenib and VPA synergistically inhibited HCC cell viability, induced cell apoptosis, along with the up-regulation of p21, Bax, cleaved caspase9, cleaved caspase3, cleaved PARP and down-regulation of Bcl-xL, suggesting this combination activated intrinsic apoptotic pathway.	Valproic Acid	30-33	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	136-139	
23836985-5	2013	In this study, we further confirmed that valproic acid inhibits the growth of Kasumi-1 cells in a murine xenograft tumor model, and that this occurs via upregulation of histone acetylation in the p21 promoter region, enhancement of p21 expression, suppression of phosphorylation of retinoblastoma protein, blocking of transcription activated by E2F, and induction of G0/G1 arrest.	Valproic Acid	41-54	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	196-199	
26339990-0	2015	Valproate administration to mice increases hippocampal p21 expression by altering genomic DNA methylation.	Valproic Acid	0-9	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	55-58	
23836985-5	2013	In this study, we further confirmed that valproic acid inhibits the growth of Kasumi-1 cells in a murine xenograft tumor model, and that this occurs via upregulation of histone acetylation in the p21 promoter region, enhancement of p21 expression, suppression of phosphorylation of retinoblastoma protein, blocking of transcription activated by E2F, and induction of G0/G1 arrest.	Valproic Acid	41-54	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	232-235