PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9536026-0	1998	Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers.	Valproic Acid	0-16	myristoylated alanine rich protein kinase C substrate	Homo sapiens	36-81	
11937071-6	2002	Inhibition of PKC with the PKC-selective inhibitor, LY333531, prevented the VPA-induced down-regulation of membrane-associated MARCKS, but had no effect on the cytosolic MARCKS reduction or the GAP-43 up-regulation.	Valproic Acid	76-79	myristoylated alanine rich protein kinase C substrate	Homo sapiens	127-133	
11937071-8	2002	Collectively, these data indicate that VPA induces neuronal differentiation, associated with a reduction in MARCKS expression and an increase in GAP-43 expression, consistent with the hypothesis that a reduction in MARCKS at the membrane may be permissive for cytoskeletal plasticity during neurite outgrowth.	Valproic Acid	39-42	myristoylated alanine rich protein kinase C substrate	Homo sapiens	108-114	
11937071-8	2002	Collectively, these data indicate that VPA induces neuronal differentiation, associated with a reduction in MARCKS expression and an increase in GAP-43 expression, consistent with the hypothesis that a reduction in MARCKS at the membrane may be permissive for cytoskeletal plasticity during neurite outgrowth.	Valproic Acid	39-42	myristoylated alanine rich protein kinase C substrate	Homo sapiens	215-221	
11937071-2	2002	In the present study we have examined the effects of VPA on the expression of two prominent substrates for protein kinase C (PKC) in the brain, MARCKS and GAP-43, which have been implicated in actin-membrane plasticity and neurite outgrowth during neuronal differentiation, respectively, and are essential to normal brain development.	Valproic Acid	53-56	myristoylated alanine rich protein kinase C substrate	Homo sapiens	144-150	
9536026-0	1998	Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers.	Valproic Acid	0-16	myristoylated alanine rich protein kinase C substrate	Homo sapiens	83-89	
9536026-5	1998	Our current results demonstrated that valproate induces a concentration- and time-dependent reduction of MARCKS in immortalized hippocampal cells that appears to be independent of both the level of muscarinic receptor-activated PI signaling as well as the concentration of myo-inositol.	Valproic Acid	38-47	myristoylated alanine rich protein kinase C substrate	Homo sapiens	105-111	
9536026-8	1998	Furthermore, the effect on MARCKS protein is additive in the presence of therapeutic concentrations of both lithium and valproate, consistent with clinical observations regarding the enhanced efficacy of the combination treatment.	Valproic Acid	120-129	myristoylated alanine rich protein kinase C substrate	Homo sapiens	27-33