PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3115230-0 1987 Teratogenicity of valproic acid and related substances in the mouse: drug accumulation and pHi in the embryo during organogenesis and structure-activity considerations. Valproic Acid 18-31 glucose-6-phosphate isomerase 1 Mus musculus 91-94 24037520-3 2013 Astrocytic, but not neuronal increase in NBCe1 activity and pHi is also seen after chronic treatment with either of the two anti-bipolar drugs carbamazepine or valproic acid. Valproic Acid 160-173 glucose-6-phosphate isomerase 1 Mus musculus 60-63 9241668-4 1997 Because of its chemical structure as a weak organic acid and its capability to induce postaxial forelimb ectrodactyly in C57BL/6 mice, we postulated that VPA acts to perturb limb morphogenesis by reducing embryonic intracellular pH (pHi). Valproic Acid 154-157 glucose-6-phosphate isomerase 1 Mus musculus 233-236 9241668-8 1997 At the highest doses, 300 and 400 mg/kg, a decrease of pHi of 0.2 to 0.3 pH units was observed uniformly throughout the limb bud 1 h after VPA treatment. Valproic Acid 139-142 glucose-6-phosphate isomerase 1 Mus musculus 55-58 9241668-11 1997 These data support the hypothesis that VPA-induced postaxial ectrodactyly in murine fetuses can be attributed to reduction in limb bud pHi. Valproic Acid 39-42 glucose-6-phosphate isomerase 1 Mus musculus 135-138