PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8801059-7	1996	The GST-mediated conjugation of GSH with 2,4-diene VPA-NACA produced two structural isomers via either 5,6- or 1,6-addition of GSH.	Valproic Acid	51-54	hematopoietic prostaglandin D synthase	Rattus norvegicus	4-7	
8801059-15	1996	These results indicate that in vivo production of the GSH conjugates of (E)-2,4-diene VPA is most likely catalyzed by GST enzymes, with the esterified diene being essential for the conjugation reaction.	Valproic Acid	86-89	hematopoietic prostaglandin D synthase	Rattus norvegicus	118-121	
34309930-6	2021	In lung homogenates, reduced glutathione, total antioxidant status levels, and superoxide dismutase, glutathione peroxidase, sodium/potassium ATPase, paraoxonase1, and carbonic anhydrase activities significantly abated, whereas catalase, glutathione reductase, glutathione-S-transferase activities insignificantly decreased in the VPA-treated group.	Valproic Acid	331-334	hematopoietic prostaglandin D synthase	Rattus norvegicus	261-286	
1502013-4	1992	In both models the cytochrome P-450 content and the enzymatic activities of 7-ethoxycoumarin O-deethylase, aldrin epoxidase and glutathione S-transferase were determined in valproate-treated hepatocytes, in controls and in phenobarbital-induced cells.	Valproic Acid	173-182	hematopoietic prostaglandin D synthase	Rattus norvegicus	128-153	
32662911-6	2020	According to the results, VPA increased lipid peroxidation, protein carbonyl, advanced oxidation protein products, total oxidant status, nitric oxide levels and glutathione-S-transferase, adenosine deaminase, xanthine oxidase activities, decreased glutathione, total antioxidant capacity levels, catalase, superoxide dismutase, glutathione peroxidase, sodium-potassium ATPase, and paraoxonase activities.	Valproic Acid	26-29	hematopoietic prostaglandin D synthase	Rattus norvegicus	161-207	
3138827-5	1988	When valproate was given i.p., the cytochromes P-450 and b5, and aldrin epoxidase and glutathione S-transferase activities were significantly induced.	Valproic Acid	5-14	hematopoietic prostaglandin D synthase	Rattus norvegicus	86-111	
32754946-5	2020	Lipid peroxidation, advanced oxidation protein products and protein carbonyl content, and superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and glutathione reductase activities increased in the VPA group.	Valproic Acid	217-220	hematopoietic prostaglandin D synthase	Rattus norvegicus	136-161	
19429109-2	2009	Previous studies in our laboratory showed that both lithium and valproate increased expression of glutathione s-transferase (GST)-M1 subtype in primary cultured rat cerebral cortical cells.	Valproic Acid	64-73	hematopoietic prostaglandin D synthase	Rattus norvegicus	98-123	
19429109-2	2009	Previous studies in our laboratory showed that both lithium and valproate increased expression of glutathione s-transferase (GST)-M1 subtype in primary cultured rat cerebral cortical cells.	Valproic Acid	64-73	hematopoietic prostaglandin D synthase	Rattus norvegicus	125-128	
15009649-2	2004	We discovered that valproate regulates expression of 28 genes, including three isoenzymes (M1, A3 and A4) of glutathione S-transferase (GST), an important protective factor against oxidative stress.	Valproic Acid	19-28	hematopoietic prostaglandin D synthase	Rattus norvegicus	109-134	
15009649-2	2004	We discovered that valproate regulates expression of 28 genes, including three isoenzymes (M1, A3 and A4) of glutathione S-transferase (GST), an important protective factor against oxidative stress.	Valproic Acid	19-28	hematopoietic prostaglandin D synthase	Rattus norvegicus	136-139	
15009649-3	2004	Because previous studies in our laboratory found that chronic valproate treatment protected cultured neurons against oxidative stress, further experiments on the regulation of GST were performed.	Valproic Acid	62-71	hematopoietic prostaglandin D synthase	Rattus norvegicus	176-179	
15009649-5	2004	Chronic valproate treatment increased mRNA levels of M1 and A4, but decreased the A3 mRNA level dose-dependently, indicating further complexities in the regulation of GST by valproate.	Valproic Acid	8-17	hematopoietic prostaglandin D synthase	Rattus norvegicus	167-170	
15009649-5	2004	Chronic valproate treatment increased mRNA levels of M1 and A4, but decreased the A3 mRNA level dose-dependently, indicating further complexities in the regulation of GST by valproate.	Valproic Acid	174-183	hematopoietic prostaglandin D synthase	Rattus norvegicus	167-170	
15009649-6	2004	The level of GST M1 protein and GST activity were also increased by chronic valproate treatment.	Valproic Acid	76-85	hematopoietic prostaglandin D synthase	Rattus norvegicus	13-16	
15009649-6	2004	The level of GST M1 protein and GST activity were also increased by chronic valproate treatment.	Valproic Acid	76-85	hematopoietic prostaglandin D synthase	Rattus norvegicus	32-35	
15009649-8	2004	The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium.	Valproic Acid	119-128	hematopoietic prostaglandin D synthase	Rattus norvegicus	48-51