PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8450838-5 1993 Brain glutamate decarboxylase activity was significantly increased after incubation of the brain slices in the presence of valproate. Valproic Acid 123-132 glutamate-ammonia ligase Rattus norvegicus 6-29 7906715-0 1994 Valproate increases glutaminase and decreases glutamine synthetase activities in primary cultures of rat brain astrocytes. Valproic Acid 0-9 glutamate-ammonia ligase Rattus norvegicus 46-66 7906715-5 1994 In astrocytes exposed to 1.2 mM valproate, glutaminase activity increased 80% by day 2 and remained elevated at day 4; glutamine synthetase activity was decreased 30%. Valproic Acid 32-41 glutamate-ammonia ligase Rattus norvegicus 119-139 8450838-6 1993 Consequently, our results suggest that the mechanism of action of valproate is related to the increase in the levels of the inhibitory neurotransmitter GABA caused by the enhancement of flux through the glutamate decarboxylase-catalyzed reaction. Valproic Acid 66-75 glutamate-ammonia ligase Rattus norvegicus 203-226 33096612-0 2020 Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity. Valproic Acid 8-21 glutamate-ammonia ligase Rattus norvegicus 109-129 2865696-0 1985 Sodium valproate stimulates the particulate form of glutamine synthetase in rat brain. Valproic Acid 0-16 glutamate-ammonia ligase Rattus norvegicus 52-72 2865696-1 1985 The anticonvulsant drug, sodium valproate, enhanced total activity of glutamine synthetase in cortical and cerebellar homogenates of the rat at concentrations of 25-50 mM, without significantly altering substrate affinity. Valproic Acid 25-41 glutamate-ammonia ligase Rattus norvegicus 70-90