PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12559103-6	2003	Supporting this possibility are recent findings that chronic treatment with valproate increased the expression of endoplasmic reticulum stress protein GRP78 and antiapoptotic factor bcl-2 in rat cerebral cortex.	Valproic Acid	76-85	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	151-156	
12559103-7	2003	Since GRP78 binds Ca(2+) and folds damaged protein, bcl-2 stabilizes mitochondrial transmembrane potential and inhibits cytochrome C release, and both GRP78 and bcl-2 have been shown to inhibit oxyradical accumulation, together these findings indicate that valproate may target one or more of these processes in order to produce neuroprotective effects.	Valproic Acid	257-266	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	151-156	
11343631-5	2001	We also found that valproate regulated the expression of the 78-kDa glucose-regulated protein (GRP78).	Valproic Acid	19-28	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	61-93	
11343631-5	2001	We also found that valproate regulated the expression of the 78-kDa glucose-regulated protein (GRP78).	Valproic Acid	19-28	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	95-100	
11343631-6	2001	Chronic treatment with valproate has also been found to increase gene transcription, mRNA and protein levels of GRP78.	Valproic Acid	23-32	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	112-117	
11032977-2	2000	We recently found with differential display polymerase chain reaction that valproate regulates the expression of the endoplasmic reticulum stress protein GRP78 in the rat cerebral cortex.	Valproic Acid	75-84	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	154-159	
11032977-4	2000	METHODS: Immunohistochemistry was used to measure protein levels of GRP78, GRP94, and calreticulin after treatment with sodium valproate (300 mg/kg, intraperitoneal) in specific rat brain regions.	Valproic Acid	120-136	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	68-73	
11032977-7	2000	CONCLUSIONS: Because GRP78, GRP94, and calreticulin possess molecular chaperone activity and bind Ca(2+) in the endoplasmic reticulum, the pharmacologic action of valproate may involve one or more of these processes.	Valproic Acid	163-172	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	21-26	
16236328-2	2006	Previous studies in our laboratory found that chronic treatment with the mood stabilizing drug valproate in rat brain increased the expression of endoplasmic reticulum (ER) stress proteins GRP78, GRP94 and calreticulin.	Valproic Acid	95-104	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	189-194	
10963759-3	2000	Previous studies in our lab have shown that one gene that may be regulated by valproate is the 78-kilodalton glucose-regulated protein (GRP78).	Valproic Acid	78-87	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	136-141	
10963759-8	2000	The roles of GRP78, GRP94 and calreticulin as molecular chaperones and calcium binding proteins, suggest that these results might have functional relevance to the therapeutic action of valproate.	Valproic Acid	185-194	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	13-18	
10051536-0	1999	Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78.	Valproic Acid	77-86	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	121-126	
10051536-8	1999	Immunoblotting revealed that GRP78 protein levels were also increased in C6 glioma cells treated with VPA under the same conditions.	Valproic Acid	102-105	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	29-34	
32901855-8	2020	VPA treatment further upregulated GRP78 expression and attenuated the levels of ATF4, CHOP, caspase-12 and p-JNK.	Valproic Acid	0-3	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	34-39	
32901855-10	2020	Mechanistically, VPA increased the total acetylation levels of histone H4 in NRK-52E cells and increased the histone H4 acetylation of the GRP78 promoter region.	Valproic Acid	17-20	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	139-144	
26647757-4	2016	In the present study, it was found that VPA increases the expression of glucose-regulated protein (GRP78) and reduces the protein expression of C/EBP-homologous protein (CHOP), growth arrest and DNA-damage-inducible gene 153 and caspase-12 in a rat model of DN.	Valproic Acid	40-43	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	99-104	
16236328-6	2006	In contrast to a classic GRP78 inducer thapsigargin, an inhibitor of the ER Ca2+ -ATPase, chronic treatment with lithium or valproate for 1 week modestly increased GRP78 expression in neuronal cells, had no effect on basal intracellular free Ca2+ concentration and does not induce cell death.	Valproic Acid	124-133	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	25-30	
16236328-6	2006	In contrast to a classic GRP78 inducer thapsigargin, an inhibitor of the ER Ca2+ -ATPase, chronic treatment with lithium or valproate for 1 week modestly increased GRP78 expression in neuronal cells, had no effect on basal intracellular free Ca2+ concentration and does not induce cell death.	Valproic Acid	124-133	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	164-169	
16236328-7	2006	These results indicate that lithium and valproate may increase expression of GRP78, GRP94 and calreticulin in primary cultured rat cerebral cortical cells without causing cell damage.	Valproic Acid	40-49	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	77-82	
16236328-8	2006	These results also suggest that the mechanism of GRP78 increase induced by lithium and valproate may be different from that of thapsigargin.	Valproic Acid	87-96	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	49-54	
16236328-3	2006	We report here that in primary cultured rat cerebral cortical cells, expression of GRP78, GRP94 and calreticulin are increased not only by valproate, but also by lithium after chronic treatment for 1 week at therapeutically relevant concentrations.	Valproic Acid	139-148	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	83-88