PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9764730-2 1998 This study compares alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) activities in sera of children treated with VPA (n=42), or CBZ (n=36) taken as a monotherapy, with VPA + CBZ combined therapy (n=36). Valproic Acid 165-168 solute carrier family 17 member 5 Homo sapiens 80-83 20371285-6 2010 Treatment with valproate sodium obviously decreased the viability of HepG2 cells, accompanied by the increased leakages of ALT, AST and LDH in a dose-dependent manner. Valproic Acid 15-31 solute carrier family 17 member 5 Homo sapiens 128-131 9764730-4 1998 The mean catalytic activity of AST was significantly elevated in groups on VPA, CBZ and VPA + CBZ treatment (2.02-, 1.49- and 1.45-fold increase, respectively) as compared to the control values. Valproic Acid 75-78 solute carrier family 17 member 5 Homo sapiens 31-34 9764730-4 1998 The mean catalytic activity of AST was significantly elevated in groups on VPA, CBZ and VPA + CBZ treatment (2.02-, 1.49- and 1.45-fold increase, respectively) as compared to the control values. Valproic Acid 88-91 solute carrier family 17 member 5 Homo sapiens 31-34 33915122-5 2021 We observed that G-CK significantly ameliorated the decrease of cell viability, elevated ALT, AST and ALP activities, significant oxidative stress, and loss of mitochondrial membrane potential induced by SVP in L02 cells. Valproic Acid 204-207 solute carrier family 17 member 5 Homo sapiens 94-97 34282594-4 2021 Results showed: (1) The overall SMD for blood AST, ALT, and GGT levels of VPA monotherapy group versus control group were 0.70 (95% CI=0.31 to 1.09, Z=3.52, p=0.0004), 0.47 (95% CI=- 0.01 to 0.95, Z=1.91, p=0.06), 0.44 (95% CI=0.29 to 0.60, Z=5.55, p<0.00001), respectively. Valproic Acid 74-77 solute carrier family 17 member 5 Homo sapiens 46-49 34282594-7 2021 Overall, our results indicated that blood AST and GGT were significantly increased in epileptic minors receiving VPA monotherapy. Valproic Acid 113-116 solute carrier family 17 member 5 Homo sapiens 42-45 28205314-6 2018 In LO2 experiment, VPA and its metabolites groups showed an obvious increment of AST, ALT, and LDH in supernate. Valproic Acid 19-22 solute carrier family 17 member 5 Homo sapiens 81-84 28782097-12 2017 Sedation was more frequent with higher N-desmethylclobazam levels in adults (p = 0.02), and AST/ALT levels were significantly higher in participants taking concomitant valproate (p < 0.01). Valproic Acid 168-177 solute carrier family 17 member 5 Homo sapiens 92-95 28974841-3 2017 AIM: The aim of the study has been to evaluate and compare the effect of CBZ and VPA monotherapy on aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) serum levels in children. Valproic Acid 81-84 solute carrier family 17 member 5 Homo sapiens 100-126 28974841-3 2017 AIM: The aim of the study has been to evaluate and compare the effect of CBZ and VPA monotherapy on aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) serum levels in children. Valproic Acid 81-84 solute carrier family 17 member 5 Homo sapiens 128-131 28974841-11 2017 CONCLUSION: The levels of enzymes AST and ALT have been elevated statistically significant in VPA group and GGT in CBZ group. Valproic Acid 94-97 solute carrier family 17 member 5 Homo sapiens 34-37