PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34523693-0 2021 Triamcinolone acetonide modulates TGF-beta2-induced angiogenic and tissue-remodeling effects in cultured human retinal pigment epithelial cells. Triamcinolone Acetonide 0-23 transforming growth factor beta 2 Homo sapiens 34-43 34523693-8 2021 TA treatment exhibited no prominent cytotoxicity but markedly antagonized TGF-beta2-induced cytostatic effects on RPE cell viability and TGF-beta2-enhanced contractility in collagen gels. Triamcinolone Acetonide 0-2 transforming growth factor beta 2 Homo sapiens 74-83 34523693-8 2021 TA treatment exhibited no prominent cytotoxicity but markedly antagonized TGF-beta2-induced cytostatic effects on RPE cell viability and TGF-beta2-enhanced contractility in collagen gels. Triamcinolone Acetonide 0-2 transforming growth factor beta 2 Homo sapiens 137-146 34523693-9 2021 In the context of TGF-beta2-related signaling, TA significantly attenuated TGF-beta2-elicited Smad2, extracellular-regulated kinase (ERK)1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation. Triamcinolone Acetonide 47-49 transforming growth factor beta 2 Homo sapiens 18-27 34523693-10 2021 Moreover, TA markedly mitigated TGF-beta2-induced VEGF upregulation through ablation of p38 signaling activity. Triamcinolone Acetonide 10-12 transforming growth factor beta 2 Homo sapiens 32-41 34523693-11 2021 TA also partially attenuated TGF-beta2-elicted expression of COL1A1, alpha-SMA, MMP-2, and MMP-9, but only suppressed TGF-beta2-induced MMP-9 gelatinolytic activity. Triamcinolone Acetonide 0-2 transforming growth factor beta 2 Homo sapiens 29-38 34523693-11 2021 TA also partially attenuated TGF-beta2-elicted expression of COL1A1, alpha-SMA, MMP-2, and MMP-9, but only suppressed TGF-beta2-induced MMP-9 gelatinolytic activity. Triamcinolone Acetonide 0-2 transforming growth factor beta 2 Homo sapiens 118-127 34523693-13 2021 In conclusion, TA may be considered a useful therapeutic agent for treating TGF-beta2-associated intraocular angiogenesis and tissue remodeling, the underlying mechanism of which may involve the ERK and p38 MAPK signaling pathways. Triamcinolone Acetonide 15-17 transforming growth factor beta 2 Homo sapiens 76-85