PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9298980-15	1997	Neomycin, which inhibits endogenous PLD by binding to its cofactor phosphatidylinositol 4,5-bisphosphate, prevents the recruitment of AP-2 not only onto endosomes but also onto the plasma membrane, suggesting that both events are mediated by PLD.	Neomycin	0-8	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-39	
11500317-3	2001	The in vitro GLUT-4 transfer could be blocked by neomycin (a PLD inhibitor), and neomycin also reduced insulin-stimulated glucose transport in intact incubated soleus muscles.	Neomycin	49-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	61-64	
9915802-5	1999	Similar to other PLDs, the PLD activity in these membrane domains is stimulated by phosphatidylinositol 4, 5-bisphosphate and is inhibited by neomycin.	Neomycin	142-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20	
14871550-9	2004	Neomycin, a high-affinity ligand of PIP2, inhibited PLD activity in human atrial myocardium, but had no effect on the activity of partially solubilized enzyme.	Neomycin	0-8	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	52-55	
14871550-10	2004	The addition of PIP2 restored the sensitivity of solubilized PLD to neomycin inhibition, indicating that neomycin inhibits PLD activity by binding to endogenous PIP2.	Neomycin	68-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	61-64	
14871550-10	2004	The addition of PIP2 restored the sensitivity of solubilized PLD to neomycin inhibition, indicating that neomycin inhibits PLD activity by binding to endogenous PIP2.	Neomycin	105-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	61-64	
14871550-10	2004	The addition of PIP2 restored the sensitivity of solubilized PLD to neomycin inhibition, indicating that neomycin inhibits PLD activity by binding to endogenous PIP2.	Neomycin	105-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	123-126	
9298980-15	1997	Neomycin, which inhibits endogenous PLD by binding to its cofactor phosphatidylinositol 4,5-bisphosphate, prevents the recruitment of AP-2 not only onto endosomes but also onto the plasma membrane, suggesting that both events are mediated by PLD.	Neomycin	0-8	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	242-245	
9346296-4	1997	Neomycin, which is known to complex with the PLD cofactor, phosphatidylinositol 4,5-bisphosphate, decreased basal and GTP[S]- or PMA-stimulated PLD activities with similar sensitivity.	Neomycin	0-8	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-48	
9346296-4	1997	Neomycin, which is known to complex with the PLD cofactor, phosphatidylinositol 4,5-bisphosphate, decreased basal and GTP[S]- or PMA-stimulated PLD activities with similar sensitivity.	Neomycin	0-8	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	144-147	
8906565-8	1996	Neomycin, a high affinity ligand of PIP2, inhibits membrane PLD activity, presumably by binding to endogenous PIP2.	Neomycin	0-8	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	60-63	
8856074-4	1996	On the other hand, neomycin, which binds to PtdIns(4,5)P2, inhibited basal and GTP[S]-stimulated PLD activities.	Neomycin	19-27	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100	
8063770-6	1994	Neomycin, a high affinity ligand of PIP2, inhibits membrane-bound PLD but has no effect on the activity of a detergent-solubilized or partially purified enzyme.	Neomycin	0-8	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	66-69	
8063770-7	1994	The addition of PIP2 restores the sensitivity of partially purified PLD to neomycin inhibition, indicating that neomycin blocks membrane PLD activity by binding to endogenous PIP2.	Neomycin	75-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	68-71	
8063770-7	1994	The addition of PIP2 restores the sensitivity of partially purified PLD to neomycin inhibition, indicating that neomycin blocks membrane PLD activity by binding to endogenous PIP2.	Neomycin	112-120	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	68-71	
8063770-7	1994	The addition of PIP2 restores the sensitivity of partially purified PLD to neomycin inhibition, indicating that neomycin blocks membrane PLD activity by binding to endogenous PIP2.	Neomycin	112-120	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	137-140	
8626786-10	1996	The PKC-mediated PLD activation was completely inhibited by neomycin, a high affinity ligand for PIP2, and this suppression was recovered by the addition of exogenous PIP2.	Neomycin	60-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20	
7890622-11	1995	This conclusion is supported by the fact that neomycin, a high affinity ligand of PtdIns-4,5-P2, also blocked PLD activation.	Neomycin	46-54	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	110-113