PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28212864-5 2017 Therefore, this study investigated the effect of acetate/phenylacetamide (GPR43 agonists) on imiquimod induced skin inflammation in mice. Acetates 49-56 free fatty acid receptor 2 Mus musculus 74-79 26075576-6 2015 Further, in the presence of acetate, the primary endogenous ligand for FFAR2, we observed FFAR2-dependent potentiation of GSIS, whereas FFAR2-specific agonists resulted in either potentiation or inhibition of GSIS, which we found to result from selective signaling through either Galphaq/11 or Galphai/o, respectively. Acetates 28-35 free fatty acid receptor 2 Mus musculus 71-76 26075576-0 2015 An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion. Acetates 3-10 free fatty acid receptor 2 Mus musculus 26-31 27658303-6 2016 The fMLP-induced neutrophil migration was significantly suppressed in wildtype mice that were treated with acetate, but not in Gpr43-/-mice, strongly suggesting a role for SCFAs in modulating neutrophil migration via GPR43. Acetates 107-114 free fatty acid receptor 2 Mus musculus 217-222 27324831-4 2016 Free Fatty Acid Receptor 2 (FFA2) is a beta cell-expressed GPCR that is activated by short chain fatty acids, particularly acetate. Acetates 123-130 free fatty acid receptor 2 Mus musculus 0-26 27324831-4 2016 Free Fatty Acid Receptor 2 (FFA2) is a beta cell-expressed GPCR that is activated by short chain fatty acids, particularly acetate. Acetates 123-130 free fatty acid receptor 2 Mus musculus 28-32 26075576-6 2015 Further, in the presence of acetate, the primary endogenous ligand for FFAR2, we observed FFAR2-dependent potentiation of GSIS, whereas FFAR2-specific agonists resulted in either potentiation or inhibition of GSIS, which we found to result from selective signaling through either Galphaq/11 or Galphai/o, respectively. Acetates 28-35 free fatty acid receptor 2 Mus musculus 90-95 26075576-6 2015 Further, in the presence of acetate, the primary endogenous ligand for FFAR2, we observed FFAR2-dependent potentiation of GSIS, whereas FFAR2-specific agonists resulted in either potentiation or inhibition of GSIS, which we found to result from selective signaling through either Galphaq/11 or Galphai/o, respectively. Acetates 28-35 free fatty acid receptor 2 Mus musculus 90-95 26075576-7 2015 Lastly, in ex vivo insulin secretion studies of human islets, we observed that acetate and FFAR2 agonists elicited different signaling properties at human FFAR2 than at mouse FFAR2. Acetates 79-86 free fatty acid receptor 2 Mus musculus 155-160 25298143-6 2014 Finally, treatment with the FFAR2 agonists acetate or phenylacetamide 1 attenuated the inflammatory response in multiple-low-dose streptozocin-induced diabetic mice, and improved the impaired glucose tolerance. Acetates 43-50 free fatty acid receptor 2 Mus musculus 28-33 25581519-4 2015 We also provide evidence that mice with dietary-induced obesity and type 2 diabetes, as compared to non-obese control mice, have increased local formation by pancreatic islets of acetate, an endogenous agonist of FFA2 and FFA3, as well as increased systemic levels. Acetates 179-186 free fatty acid receptor 2 Mus musculus 213-217 25581519-8 2015 In summary, under diabetic conditions elevated acetate acts on FFA2 and FFA3 to inhibit proper glucose-stimulated insulin secretion, and we expect antagonists of FFA2 and FFA3 to improve insulin secretion in type 2 diabetes. Acetates 47-54 free fatty acid receptor 2 Mus musculus 63-67 16123168-0 2005 Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Acetates 0-7 free fatty acid receptor 2 Mus musculus 74-80 18499755-1 2008 G protein-coupled receptor 43 (GPR43) has been identified as a receptor for short-chain fatty acids that include acetate and propionate. Acetates 113-120 free fatty acid receptor 2 Mus musculus 0-29 18499755-1 2008 G protein-coupled receptor 43 (GPR43) has been identified as a receptor for short-chain fatty acids that include acetate and propionate. Acetates 113-120 free fatty acid receptor 2 Mus musculus 31-36 18499755-5 2008 We show that adipocytes treated with GPR43 natural ligands, acetate and propionate, exhibit a reduction in lipolytic activity. Acetates 60-67 free fatty acid receptor 2 Mus musculus 37-42 18499755-7 2008 In a mouse in vivo model, we show that the activation of GPR43 by acetate results in the reduction in plasma free fatty acid levels without inducing the flushing side effect that has been observed by the activation of nicotinic acid receptor, GPR109A. Acetates 66-73 free fatty acid receptor 2 Mus musculus 57-62 20399779-5 2010 Acetate but not butyrate stimulated leptin secretion in wild-type mesenteric adipocytes, consistent with mediation of the response by GPR43 rather than GPR41. Acetates 0-7 free fatty acid receptor 2 Mus musculus 134-139 16123168-13 2005 We conclude that acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43, but not through GPCR41. Acetates 17-24 free fatty acid receptor 2 Mus musculus 127-133 33614540-9 2020 Results: After acetate treatment, the expression levels of TNF-alpha, IL-1beta, IL-18, NLRP3, and caspase-1 were significantly reduced, while the expression of GPR43 was increased. Acetates 15-22 free fatty acid receptor 2 Mus musculus 160-165 34530928-0 2021 Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice. Acetates 26-33 free fatty acid receptor 2 Mus musculus 80-85 34530928-9 2021 CONCLUSION: These findings demonstrated that the commensal microbiome-acetate-FFAR2 molecular circuit improves insulin sensitivity in the liver and prevents the development of NAFLD/NASH. Acetates 70-77 free fatty acid receptor 2 Mus musculus 78-83 32756447-10 2020 However, the administration of GLPG0974-the inhibitor of G protein-coupled receptor 43 (GPR43), which is the receptor of SCFAs-abolished exercise-mediated alleviation in IR in vivo and acetate-mediated reduction of skeletal muscle IR (SMIR) in vitro. Acetates 185-192 free fatty acid receptor 2 Mus musculus 57-86 33489123-11 2021 We found that acetate increased numbers of colonic IL-22 producing TCRalphabeta+CD8alphabeta+ and TCRgammadelta+CD8alphaalpha+ intraepithelial lymphocytes expressing GPR43. Acetates 14-21 free fatty acid receptor 2 Mus musculus 166-171 32756447-10 2020 However, the administration of GLPG0974-the inhibitor of G protein-coupled receptor 43 (GPR43), which is the receptor of SCFAs-abolished exercise-mediated alleviation in IR in vivo and acetate-mediated reduction of skeletal muscle IR (SMIR) in vitro. Acetates 185-192 free fatty acid receptor 2 Mus musculus 88-93 32139755-7 2020 Caecal and plasma acetate levels were elevated by GCL2505 in WT and Gpr43-/- mice, but the negative correlation between plasma acetate levels and body fat accumulation was observed only in WT mice. Acetates 18-25 free fatty acid receptor 2 Mus musculus 68-73 32482686-3 2020 Kidney transplants were performed from BALB/c(H2d) to B6(H2b) mice as allografts in wild-type and recipient mice lacking the G protein-coupled receptor GPR43 (the metabolite-sensing receptor of acetate). Acetates 194-201 free fatty acid receptor 2 Mus musculus 152-157 32279475-2 2020 Free fatty acid receptor 2 (FFA2, formerly known as GPR43) is a specific receptor for short-chain fatty acids, such as acetate that regulates inflammatory responses. Acetates 119-126 free fatty acid receptor 2 Mus musculus 0-26 32279475-2 2020 Free fatty acid receptor 2 (FFA2, formerly known as GPR43) is a specific receptor for short-chain fatty acids, such as acetate that regulates inflammatory responses. Acetates 119-126 free fatty acid receptor 2 Mus musculus 28-32 32279475-2 2020 Free fatty acid receptor 2 (FFA2, formerly known as GPR43) is a specific receptor for short-chain fatty acids, such as acetate that regulates inflammatory responses. Acetates 119-126 free fatty acid receptor 2 Mus musculus 52-57 32139660-10 2020 These results suggest that acetate may bind to GPR43, thereby inhibiting microglial activity, suppressing neuroinflammation, and preventing memory deficits. Acetates 27-34 free fatty acid receptor 2 Mus musculus 47-52 31337751-0 2019 Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination. Acetates 0-7 free fatty acid receptor 2 Mus musculus 51-56 31337751-4 2019 Here, we demonstrate that acetate attenuates inflammasome activation via GPR43 in a Ca2+-dependent manner. Acetates 26-33 free fatty acid receptor 2 Mus musculus 73-78 31337751-5 2019 Through binding to GPR43, acetate activates the Gq/11 subunit and subsequent phospholipase C-IP3 signaling to decrease Ca2+ mobilization. Acetates 26-33 free fatty acid receptor 2 Mus musculus 19-24 31337751-8 2019 Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases. Acetates 45-52 free fatty acid receptor 2 Mus musculus 90-95