PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27845373-6 2016 We showed that MMPP strongly inhibited pro-inflammatory responses by inhibiting in vitro STAT3 activation and its downstream signalling in murine macrophages and human synoviocytes from patients with RA. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 15-19 signal transducer and activator of transcription 3 Mus musculus 89-94 31146332-7 2019 Increased activation of STAT3, p38, and monoamine oxidase B (MAO-B) were observed in the substantia nigra and striatum after MPTP injection, effects that were attenuated by MMPP treatment. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 173-177 signal transducer and activator of transcription 3 Mus musculus 24-29 31146332-8 2019 Furthermore, MMPP inhibited STAT3 activity and expression of neuroinflammatory proteins, including ionized calcium binding adaptor molecule 1 (Iba1), inducible nitric oxide synthase (iNOS), and glial fibrillary acidic protein (GFAP) in 1-methyl-4-phenylpyridinium (MPP+; 0.5 mM)-treated primary cultured cells. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 13-17 signal transducer and activator of transcription 3 Mus musculus 28-33 31146332-10 2019 Collectively, our results suggest that MMPP may be an anti-inflammatory agent that attenuates dopaminergic neurodegeneration and neuroinflammation through MAO-B and MAPK pathway-dependent inhibition of STAT3 activation. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 39-43 signal transducer and activator of transcription 3 Mus musculus 202-207 31146332-2 2019 We have previously demonstrated that (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor, has anti-inflammatory properties in several inflammatory disease models. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 98-102 signal transducer and activator of transcription 3 Mus musculus 117-167 31146332-2 2019 We have previously demonstrated that (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor, has anti-inflammatory properties in several inflammatory disease models. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 98-102 signal transducer and activator of transcription 3 Mus musculus 169-174 29052076-9 2017 Moreover, MMPP treatment suppressed DNA binding activities of the activation of STAT3 in in vivo and in vitro. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 10-14 signal transducer and activator of transcription 3 Mus musculus 80-85 29052076-10 2017 These results indicated that MMPP inhibits LPS-induced amyloidogenesis and neuroinflammation via inhibition of STAT3. 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol 29-33 signal transducer and activator of transcription 3 Mus musculus 111-116