PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1910444-4 1991 The inhibitory activity of the compounds against thymidylate synthetase is enhanced by the presence of apolar groups with a positive inductive effect, provided these groups do not extend the plane of the 2,4-DP ring. Uracil 204-210 thymidylate synthetase Homo sapiens 49-71 2015598-11 1991 This strongly suggests that growth inhibition following thymidylate synthase inhibition is mediated through an increase in intracellular dUTP, leading to uracil misincorporation into DNA, its subsequent excision, and resultant strand breakage. Uracil 154-160 thymidylate synthetase Homo sapiens 56-76 30927565-0 2019 Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs. Uracil 53-59 thymidylate synthetase Homo sapiens 107-127 2495166-1 1989 The authors examined the relationship between the level of thymidylate synthase (TS) and the sensitivity to 5-fluorouracil (5-FU) and UFT, a combined oral preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) and uracil in a molar ratio of 1:4. Uracil 116-122 thymidylate synthetase Homo sapiens 59-79 2495166-1 1989 The authors examined the relationship between the level of thymidylate synthase (TS) and the sensitivity to 5-fluorouracil (5-FU) and UFT, a combined oral preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) and uracil in a molar ratio of 1:4. Uracil 116-122 thymidylate synthetase Homo sapiens 81-83 30927565-0 2019 Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs. Uracil 53-59 thymidylate synthetase Homo sapiens 129-131 30927565-2 2019 Here, based on the structures and pharmacological properties of two types of TS inhibitors, through a molecular assembly principle of drugs design, we designed and synthesized a series of 30 novel uracil derivatives as TS inhibitors. Uracil 197-203 thymidylate synthetase Homo sapiens 77-79 30927565-2 2019 Here, based on the structures and pharmacological properties of two types of TS inhibitors, through a molecular assembly principle of drugs design, we designed and synthesized a series of 30 novel uracil derivatives as TS inhibitors. Uracil 197-203 thymidylate synthetase Homo sapiens 219-221 27517750-1 2016 5-fluorodeoxyuridine (5-FdU, floxuridine) is active against multiple cancers through the inhibition of thymidylate synthase, which consequently introduces uracil and 5-FU incorporation into the genome. Uracil 155-161 thymidylate synthetase Homo sapiens 103-123 28796306-3 2017 Reconstitution of both flavin-dependent RNA methyltransferase and thymidylate synthase apoproteins with this synthetic compound led to active enzymes for the C5-uracil methylation within their respective transfer RNA and dUMP substrate. Uracil 161-167 thymidylate synthetase Homo sapiens 66-86 25997777-0 2015 Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine. Uracil 69-75 thymidylate synthetase Homo sapiens 0-20 26271935-0 2015 Correction: Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine. Uracil 81-87 thymidylate synthetase Homo sapiens 12-32 26271935-1 2015 Correction for "Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine" by Palwinder Singh et al., Chem. Uracil 85-91 thymidylate synthetase Homo sapiens 16-36 23253900-2 2013 Its active metabolite inhibits thymidylate synthase, which deprives cells of TTP and causes the introduction of uracil in DNA. Uracil 112-118 thymidylate synthetase Homo sapiens 31-51 21222484-0 2011 Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA. Uracil 123-129 thymidylate synthetase Homo sapiens 14-34 20647221-1 2011 BACKGROUND: To assess the predictive value of polymorphism in nine genes, primarily thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT), which relates to 5-fluorouracil (5-FU) metabolism, for toxicity in patients treated with oral uracil/tegafur (UFT) plus leucovorin (LV). Uracil 181-187 thymidylate synthetase Homo sapiens 84-104 15322254-1 2004 Uracil misincorporation into DNA and its associated misrepair have been implicated as contributing components of cytotoxicity resulting from treatment with thymidylate synthase inhibitors. Uracil 0-6 thymidylate synthetase Homo sapiens 156-176 17659576-9 2007 CONCLUSION: This study supports the hypothesis that reduced MTHFR activity and enhanced TYMS activity, both of which are essential elements in minimizing uracil misincorporation into DNA, may protect against the development of HCC. Uracil 154-160 thymidylate synthetase Homo sapiens 88-92 17143493-1 2007 The present study assesses the effects of neo-adjuvant chemotherapy (NAC) with uracil and tegafur (UFT) alone vs UFT plus cyclophosphamide (CPA), on the activity of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in breast cancer tissues. Uracil 79-85 thymidylate synthetase Homo sapiens 165-185 20044377-7 2010 High expression of thymidylate synthase, an enzyme that is important in purine synthesis and DNA replication, has been associated with decreased response to uracil antimetabolites, and may also be an important prognostic factor in patients receiving pemetrexed. Uracil 157-163 thymidylate synthetase Homo sapiens 19-39 19370033-1 2009 Biosynthesis of the DNA base thymine depends on activity of the enzyme thymidylate synthase to catalyse the methylation of the uracil moiety of 2"-deoxyuridine-5"-monophosphate. Uracil 127-133 thymidylate synthetase Homo sapiens 71-91 15785747-6 2005 In patients with stage II-III NSCLCs, furthermore, the survival of UFT (a combination of tegafur and uracil)-treated patients with TS-negative tumours was significantly better than those of any other patients. Uracil 101-107 thymidylate synthetase Homo sapiens 131-133 14636615-2 2003 We investigated the relationship between the level of tumoural TS expression and response to tegafur/uracil (UFT) in 26 patients with oral squamous cell carcinoma. Uracil 101-107 thymidylate synthetase Homo sapiens 63-65 11487279-2 2001 Loss of viability following TS inhibition occurs as a consequence of depleted dTTP pools and at least in some cell lines, accumulation of dUTP and subsequent misincorporation of uracil into DNA. Uracil 178-184 thymidylate synthetase Homo sapiens 28-30 12450432-1 2001 Thymidylate synthase (TS) is an important target for chemotherapy drugs, such as 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (FUDR), oral 5-FU prodrugs (e.g., uracil/tegafur [UFT], S-1, and capecitabine), and other novel folate-based drugs (e.g., raltitrexed, pemetrexed, and nolatrexed). Uracil 89-95 thymidylate synthetase Homo sapiens 0-20 12450432-1 2001 Thymidylate synthase (TS) is an important target for chemotherapy drugs, such as 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (FUDR), oral 5-FU prodrugs (e.g., uracil/tegafur [UFT], S-1, and capecitabine), and other novel folate-based drugs (e.g., raltitrexed, pemetrexed, and nolatrexed). Uracil 89-95 thymidylate synthetase Homo sapiens 22-24 8464418-0 1993 [Changes of the number of FdUMP binding sites of thymidylate synthase and folate pools in human colorectal carcinomas following the administration of tegafur and uracil: preliminary report]. Uracil 162-168 thymidylate synthetase Homo sapiens 49-69 8206932-1 1994 The synthesis of thymidylate synthase (TS) from 5-fluorouracil (FUra)- and 5-bromouracil (BrUra)-substituted mRNAs was examined to investigate the effect of incorporation of uracil (Ura) analogs on translation. Uracil 56-62 thymidylate synthetase Homo sapiens 17-37 8206932-1 1994 The synthesis of thymidylate synthase (TS) from 5-fluorouracil (FUra)- and 5-bromouracil (BrUra)-substituted mRNAs was examined to investigate the effect of incorporation of uracil (Ura) analogs on translation. Uracil 56-62 thymidylate synthetase Homo sapiens 39-41 8206932-1 1994 The synthesis of thymidylate synthase (TS) from 5-fluorouracil (FUra)- and 5-bromouracil (BrUra)-substituted mRNAs was examined to investigate the effect of incorporation of uracil (Ura) analogs on translation. Uracil 65-68 thymidylate synthetase Homo sapiens 17-37 10952785-1 2000 Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS) inhibition. Uracil 0-6 thymidylate synthetase Homo sapiens 103-123 10952785-1 2000 Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS) inhibition. Uracil 0-6 thymidylate synthetase Homo sapiens 125-127 8206932-1 1994 The synthesis of thymidylate synthase (TS) from 5-fluorouracil (FUra)- and 5-bromouracil (BrUra)-substituted mRNAs was examined to investigate the effect of incorporation of uracil (Ura) analogs on translation. Uracil 65-68 thymidylate synthetase Homo sapiens 39-41 8206932-2 1994 Human TS cDNA was transcribed in the presence of Ura-, FUra-, or BrUTP to obtain 100% substituted mRNA. Uracil 49-52 thymidylate synthetase Homo sapiens 6-8 8206932-5 1994 Time courses of TS formation revealed a characteristic peak which occurred at 45 min for the Ura- and FUra-RNAs and at 2 h for the BrUra-RNA. Uracil 93-96 thymidylate synthetase Homo sapiens 16-18