PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14642566-1 2003 SMUG1 is a recently discovered uracil-DNA glycosylase with the ability to remove uracil from single-stranded as well as double-stranded DNA. Uracil 31-37 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 0-5 16407970-0 2006 SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair. Uracil 24-30 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 0-5 24771041-0 2014 Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation. Uracil 0-6 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 30-35 12820976-4 2003 Ung knockout mice display no increase in mutation frequency due to a second UDG activity, SMUG1, which is specialized for antimutational uracil excision in mammalian cells. Uracil 137-143 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 90-95 28775312-0 2017 Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Uracil 0-6 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 115-120 28775312-1 2017 Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional uracil DNA glycosylase (SMUG1). Uracil 63-69 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 242-247 28775312-7 2017 Contrastingly, Ung -/- Smug1 -/- mice showed a synergistic increase in uracil levels with up to 25-fold higher uracil levels than wild type. Uracil 71-77 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 23-28 28775312-7 2017 Contrastingly, Ung -/- Smug1 -/- mice showed a synergistic increase in uracil levels with up to 25-fold higher uracil levels than wild type. Uracil 111-117 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 23-28 28775312-10 2017 In conclusion, we showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency. Uracil 64-70 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 30-35 24920531-11 2014 Similar to UNG, SMUG1 is an uracil glycosylase which can remove the uracil base. Uracil 28-34 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 16-21 22447450-0 2012 Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice. Uracil 73-79 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 21-26 22447450-4 2012 Inactivation of Smug1 when combined with inactivation of the Ung uracil-DNA glycosylase gene leads to a loss of nearly all detectable uracil excision activity. Uracil 65-71 single-strand selective monofunctional uracil DNA glycosylase Mus musculus 16-21