PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17622497-3 2008 GDPs are triggered by the CA3 region and they are seen as brief recurrent events in field-potential recordings, paralleled by depolarization and spiking of pyramidal neurons. gdps 0-4 carbonic anhydrase 3 Rattus norvegicus 26-29 16706841-2 2006 We have recently shown that in the early postnatal period, the intrinsic bursting of interconnected CA3 pyramidal neurons generates network events, which were originally called giant depolarizing potentials (GDPs). gdps 208-212 carbonic anhydrase 3 Rattus norvegicus 100-103 16644806-1 2006 Earlier studies indicate a crucial role for the interconnected network of intrinsically bursting CA3 pyramidal neurons in the generation of in vivo hippocampal sharp waves (SPWs) and their proposed neonatal in vitro counterparts, the giant depolarizing potentials (GDPs). gdps 265-269 carbonic anhydrase 3 Rattus norvegicus 97-100 16307610-4 2005 Here we focus on HCN1, the prevalent HCN channel isoform in neonatal hippocampus, and demonstrate an HCN1 spatiotemporal expression pattern in both CA3 principal cells and interneurons that correlates with the developmental profile of GDPs. gdps 235-239 carbonic anhydrase 3 Rattus norvegicus 148-151 16307610-6 2005 Furthermore, ZD7288 specifically abolishes spontaneous bursting of the CA3 pyramidal cells at frequencies typical of GDPs without major influence on interneuronal firing. gdps 117-121 carbonic anhydrase 3 Rattus norvegicus 71-74 9051587-4 1997 Dual recordings revealed that during the generation of GDPs in CA3 pyramidal cells, the interneurons fire bursts of spikes, on average 4.5 +/- 1.4 spikes per burst (cell-attached mode). gdps 55-59 carbonic anhydrase 3 Rattus norvegicus 63-66 11579159-2 2001 The whole-cell configuration of the patch-clamp technique was used to study the modulation of giant depolarizing potentials (GDPs) by nicotinic acetylcholine receptors (nAChRs) in CA3 hippocampal neurons in slices from postnatal day (P) 2-6 rats. gdps 125-129 carbonic anhydrase 3 Rattus norvegicus 180-183 10373692-2 1999 The whole-cell patch clamp technique was used to study the role of muscarinic receptors in regulating the frequency of giant depolarizing potentials (GDPs) in CA3 hippocampal neurones in slices from postnatal (P) P1-P8 rats. gdps 150-154 carbonic anhydrase 3 Rattus norvegicus 159-162 9051587-8 1997 The network elements required for the generation of GDPs are present in local CA3 circuits since spontaneous GDPs were present in the isolated CA3 subfield of the hippocampal slice. gdps 52-56 carbonic anhydrase 3 Rattus norvegicus 143-146 9051587-8 1997 The network elements required for the generation of GDPs are present in local CA3 circuits since spontaneous GDPs were present in the isolated CA3 subfield of the hippocampal slice. gdps 109-113 carbonic anhydrase 3 Rattus norvegicus 78-81 9051587-8 1997 The network elements required for the generation of GDPs are present in local CA3 circuits since spontaneous GDPs were present in the isolated CA3 subfield of the hippocampal slice. gdps 109-113 carbonic anhydrase 3 Rattus norvegicus 143-146 9051587-13 1997 Pharmacological study of this response revealed that excitation of SR-CA3 interneurons during GDPs is determined by the co-operative depolarizing actions mediated by GABAA and glutamate (AMPA and NMDA) receptors. gdps 94-98 carbonic anhydrase 3 Rattus norvegicus 70-73 9051587-16 1997 It is concluded that synchronous activation of SR-CA3 interneurons during generation of GDPs is mediated synaptically and is determined by the co-operation of (i) excitatory GABAergic connections between interneurons and (ii) glutamatergic connections to interneurons originating presumably from the pyramidal cells. gdps 88-92 carbonic anhydrase 3 Rattus norvegicus 50-53 15930375-7 2005 The present data indicate that glutamatergic CA3 neurons have an instructive, pacemaker role in the generation of GDPs, whereas both synaptic and tonic depolarizing GABAergic mechanisms exert a temporally nonpatterned, facilitatory action in the generation of these network events. gdps 114-118 carbonic anhydrase 3 Rattus norvegicus 45-48 9051587-8 1997 The network elements required for the generation of GDPs are present in local CA3 circuits since spontaneous GDPs were present in the isolated CA3 subfield of the hippocampal slice. gdps 52-56 carbonic anhydrase 3 Rattus norvegicus 78-81 8583396-2 1995 Intracellular recordings were used to study the role of metabotropic glutamate receptors (mGluRs) in modulating GABA-mediated giant depolarizing potentials (GDPs) in immature rat hippocampal CA3 neurones. gdps 157-161 carbonic anhydrase 3 Rattus norvegicus 191-194 2168059-3 1990 (2) Intracellular observations in slices reveal the presence in CA3 pyramidal neurons between P0 and P6 (postnatal days) of spontaneous giant depolarizing potentials (GDPs); these are mediated by GABA acting on GABAA receptors and modulated presynaptically by NMDA receptors. gdps 167-171 carbonic anhydrase 3 Rattus norvegicus 64-67 1846946-6 1991 Our results indicate that naturally occurring spontaneous giant depolarizing synaptic potentials (GDPs) in young CA3 pyramidal neurones, mediated by the release of GABA (gamma-aminobutyric acid), are induced by endogenously released zinc. gdps 98-102 carbonic anhydrase 3 Rattus norvegicus 113-116 2153293-3 1990 In keeping with our earlier study, during the first postnatal week, CA3 neurons exhibited giant depolarizing potentials (GDPs). gdps 121-125 carbonic anhydrase 3 Rattus norvegicus 68-71 24357090-2 2014 Spontaneous giant depolarizing potentials (GDPs) were first identified with single-cell recordings from rat CA3 pyramidal neurons, but here we identify and characterize a large-scale spontaneous network activity we term global network activation (GNA) in the developing mouse hippocampal slices, which is measured macroscopically by fast voltage-sensitive dye imaging. gdps 43-47 carbonic anhydrase 3 Rattus norvegicus 108-111 28701925-1 2017 During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). gdps 124-128 carbonic anhydrase 3 Rattus norvegicus 32-35 28701925-2 2017 GDPs are characterized by synchronous depolarization and firing of CA3 pyramidal cells followed by afterhyperpolarization (GDP-AHP). gdps 0-4 carbonic anhydrase 3 Rattus norvegicus 67-70 22492030-4 2012 Analysis of the simultaneous behavior of multiple CA3 neurons during synchronous GDPs revealed a repeatable activation order from burst to burst. gdps 81-85 carbonic anhydrase 3 Rattus norvegicus 50-53 22492030-5 2012 This was validated using several statistical methods, including high Kendall"s coefficient of concordance values for firing order during GDPs, high Pearson"s correlations of cellular activation times between burst pairs, and latent class analysis, which revealed a population of 5-6% of CA3 neurons reliably firing very early during GDPs. gdps 333-337 carbonic anhydrase 3 Rattus norvegicus 287-290