PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31213989-6 2019 We therefore tested the effect of leptin on GDPs. gdps 44-48 leptin Rattus norvegicus 34-40 31213989-7 2019 Leptin increased GDPs frequency between the postnatal days (P) 1 and 3 via a calcium/Calmodulin-dependent kinase (CaMK) and extracellular signal-related kinase (ERK) dependent pathways. gdps 17-21 leptin Rattus norvegicus 0-6 31213989-8 2019 Between P6 and P7, leptin inhibited the frequency of GDPs through the activation of large conductance Ca2+ activated K+ (BK) channels driven by a phosphoinositol-3 kinase (PI3K) dependent pathway. gdps 53-57 leptin Rattus norvegicus 19-25 31213989-9 2019 These results show that leptin exerts a bi-directional and age-dependent control of GDPs and extends the scope of leptin"s action in the developing brain. gdps 84-88 leptin Rattus norvegicus 24-30