PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9951426-2	1999	We recently reported 2 fatal cases in patients taking pimozide and clarithromycin and we have shown that clarithromycin inhibits CYP3A-mediated metabolism of pimozide in vitro.	Pimozide	54-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	129-134	
9951426-2	1999	We recently reported 2 fatal cases in patients taking pimozide and clarithromycin and we have shown that clarithromycin inhibits CYP3A-mediated metabolism of pimozide in vitro.	Pimozide	158-166	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	129-134	
9951426-13	1999	Clarithromycin inhibited CYP3A-mediated pimozide metabolism and the resulting elevation in plasma concentrations may increase the risk of pimozide cardiotoxicity.	Pimozide	40-48	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-30	
9951426-13	1999	Clarithromycin inhibited CYP3A-mediated pimozide metabolism and the resulting elevation in plasma concentrations may increase the risk of pimozide cardiotoxicity.	Pimozide	138-146	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-30	
9580580-7	1998	The formation rate of DHPBI from 25 microM pimozide in nine human livers correlated significantly with the catalytic activity of CYP3A (Spearman r = 0.79, P = .028), but not with other isoforms.	Pimozide	43-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	129-134	
9580580-9	1998	Recombinant human CYP3A4 catalyzed DHPBI formation from 10 microM pimozide at the highest rate (V = 2.2 +/- 0.89 pmol/min/pmol P450) followed by CYP1A2 (V = 0.23 +/- 0.08 pmol/min/pmol P450), but other isoforms tested did not.	Pimozide	66-74	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-24	
9580580-11	1998	Pimozide itself was a potent inhibitor of CYP2D6 in HLMs when preincubated for 15 min (Ki = 0.75 +/- 0.98 microM) and a moderate inhibitor of CYP3A (Ki = 76.7 +/- 34.5 microM), with no significant effect on other isoforms tested.	Pimozide	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-147	
9580580-12	1998	Our results suggest that pimozide metabolism is catalyzed mainly by CYP3A, but CYP1A2 also contributes.	Pimozide	25-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-73	
9580580-13	1998	Pimozide metabolism is likely to be subject to interindividual variability in CYP3A and CYP1A2 expression and to drug interactions involving these isoforms.	Pimozide	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-83	
25868121-4	2015	Aripiprazole, haloperidol, pimozide, and risperidone are antipsychotics that are metabolized by CYP3A4 and CYP2D6.	Pimozide	27-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-102	
32847865-0	2020	The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.	Pimozide	63-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-30	
32847865-2	2020	Prior in vitro studies characterized N-dealkylation of pimozide to 1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one (DHPBI) via CYP3A4, and to a lesser extent CYP1A2, as the only notable routes of pimozide biotransformation.	Pimozide	55-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-137	
32847865-2	2020	Prior in vitro studies characterized N-dealkylation of pimozide to 1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one (DHPBI) via CYP3A4, and to a lesser extent CYP1A2, as the only notable routes of pimozide biotransformation.	Pimozide	200-208	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-137