PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6140010-1 1983 The activity of tyrosine hydroxylase (TH) in the corpus striatum of haloperidol treated and control rats has been examined. Haloperidol 68-79 tyrosine hydroxylase Rattus norvegicus 16-36 1970757-2 1990 The studies described herein were designed to test the hypothesis that a neuroleptic, haloperidol, may alter the level of expression of the tyrosine hydroxylase and cholecystokinin genes in discrete brain regions. Haloperidol 86-97 tyrosine hydroxylase Rattus norvegicus 140-160 1970757-4 1990 In situ hybridization was employed to quantitate changes in concentration of mRNA for tyrosine hydroxylase and cholecystokinin in the ventral tegmental area, substantia nigra, and locus ceruleus after acute or chronic treatment with haloperidol or vehicle. Haloperidol 233-244 tyrosine hydroxylase Rattus norvegicus 86-106 2871513-7 1986 Concurrent administration of haloperidol (HALO; 2 mg/kg, 4 doses) with MPTP significantly enhanced the depression of the activity of tyrosine hydroxylase in the striatum caused by MPTP, while treatment with haloperidol alone had no such effect. Haloperidol 29-40 tyrosine hydroxylase Rattus norvegicus 133-153 2871513-7 1986 Concurrent administration of haloperidol (HALO; 2 mg/kg, 4 doses) with MPTP significantly enhanced the depression of the activity of tyrosine hydroxylase in the striatum caused by MPTP, while treatment with haloperidol alone had no such effect. Haloperidol 42-46 tyrosine hydroxylase Rattus norvegicus 133-153 6140010-1 1983 The activity of tyrosine hydroxylase (TH) in the corpus striatum of haloperidol treated and control rats has been examined. Haloperidol 68-79 tyrosine hydroxylase Rattus norvegicus 38-40 6140010-2 1983 The activation of TH by haloperidol caused a decrease in the Km for tetrahydrobiopterin but no change in the Vmax. Haloperidol 24-35 tyrosine hydroxylase Rattus norvegicus 18-20 25696-3 1978 Four days following the administration of haloperidol (400 microgram/kg) or 10 days after castration, there was a significant increase in the rate of turnover of DA but not NE in the ME accompanied by an increase in the Vmax but not Km for the substrate or cofactor of TH. Haloperidol 42-53 tyrosine hydroxylase Rattus norvegicus 269-271 6136885-8 1983 Haloperidol increased TH activity in both light-exposed and light-deprived retinas. Haloperidol 0-11 tyrosine hydroxylase Rattus norvegicus 22-24 25696-4 1978 Furthermore, the administration of haloperidol to hypophysectomized rats also significantly increased the TH activity in the ME, indicating that such changes may occur independently of any changes in serum prolactin levels. Haloperidol 35-46 tyrosine hydroxylase Rattus norvegicus 106-108 1360740-3 1992 Ip injection of either SPD 5.0 or Hal 2.5 mg.kg-1 after NSD 1015 50 mg.kg-1 or NSD 1015 plus GBL 750 mg.kg-1 also augmented tyrosine hydroxylase (TH) activity in the rat striatum. Haloperidol 34-37 tyrosine hydroxylase Rattus norvegicus 124-144 17028028-0 2007 Chronic high-dose haloperidol has qualitatively similar effects to risperidone and clozapine on immediate-early gene and tyrosine hydroxylase expression in the rat locus coeruleus but not medial prefrontal cortex. Haloperidol 18-29 tyrosine hydroxylase Rattus norvegicus 121-141 17028028-9 2007 Haloperidol caused a smaller increase in TH expression in the LC, but did not alter expression in the mPFC. Haloperidol 0-11 tyrosine hydroxylase Rattus norvegicus 41-43 10700558-2 2000 Systemic administration of the DA receptor antagonist haloperidol caused a sustained (up to 12 h) increase in plasma prolactin concentrations that was accompanied by a transient increase (at 3 h) in the percentage of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons containing FRA-IR nuclei in the DM-ARC. Haloperidol 54-65 tyrosine hydroxylase Rattus norvegicus 217-237 9521094-8 1998 After 6 months of treatment, TH activity in HAL-treated rats was 130% higher than that in the control rats. Haloperidol 44-47 tyrosine hydroxylase Rattus norvegicus 29-31 9521094-9 1998 After 9 months of treatment, TH activity in HAL-treated rats was 81% higher than that in control rats. Haloperidol 44-47 tyrosine hydroxylase Rattus norvegicus 29-31 8878114-0 1996 Effect of a pyridinium metabolite derived from haloperidol on the activities of striatal tyrosine hydroxylase in freely moving rats. Haloperidol 47-58 tyrosine hydroxylase Rattus norvegicus 89-109 21396352-11 2011 Treatment with HAL or RISP resulted in a significant reduction (HAL 27%; RISP 25%) in the number of TH-immunoreactive cells present in the medial SN pars compacta. Haloperidol 15-18 tyrosine hydroxylase Rattus norvegicus 100-102 21396352-11 2011 Treatment with HAL or RISP resulted in a significant reduction (HAL 27%; RISP 25%) in the number of TH-immunoreactive cells present in the medial SN pars compacta. Haloperidol 64-67 tyrosine hydroxylase Rattus norvegicus 100-102 17466452-0 2007 Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment. Haloperidol 132-143 tyrosine hydroxylase Rattus norvegicus 51-71 17466452-3 2007 In the present study, we investigated the possibility of reversing the HAL-induced changes in locomotor activity and in striatal tyrosine hydroxylase (TH) of rats. Haloperidol 71-74 tyrosine hydroxylase Rattus norvegicus 129-149 12112400-10 2002 The density of symmetric synapses (mean +/- SD, per 100/microm(3)) formed by tyrosine hydroxylase (TH) containing terminals in haloperidol treated rats (3.58 +/- 1.64) was not significantly different from that of controls (3.06 +/- 1.00). Haloperidol 127-138 tyrosine hydroxylase Rattus norvegicus 77-97 7911985-4 1994 Co-administration of diazepam with a dopamine antagonist haloperidol did not further elevate, but rather, reduced haloperidol-induced increases in TH labeling. Haloperidol 57-68 tyrosine hydroxylase Rattus norvegicus 147-149 7911985-4 1994 Co-administration of diazepam with a dopamine antagonist haloperidol did not further elevate, but rather, reduced haloperidol-induced increases in TH labeling. Haloperidol 114-125 tyrosine hydroxylase Rattus norvegicus 147-149 7911985-5 1994 These results suggest that haloperidol and diazepam regulate TH gene expression in the SNr commonly by depressing dopaminergic transmission, and that diazepam activates TH expression in a group of SNr neurons which express this gene after haloperidol treatment. Haloperidol 27-38 tyrosine hydroxylase Rattus norvegicus 61-63 7907932-0 1994 Haloperidol activates tyrosine hydroxylase gene-expression in the rat substantia nigra, pars reticulata. Haloperidol 0-11 tyrosine hydroxylase Rattus norvegicus 22-42 7907932-2 1994 Number and density of both TH immunoreactive and TH cRNA labeled cells were increased in the pars reticulata of the substantia nigra (SNr) 8 h after single administration of a dopamine antagonist haloperidol. Haloperidol 196-207 tyrosine hydroxylase Rattus norvegicus 27-29 7907932-2 1994 Number and density of both TH immunoreactive and TH cRNA labeled cells were increased in the pars reticulata of the substantia nigra (SNr) 8 h after single administration of a dopamine antagonist haloperidol. Haloperidol 196-207 tyrosine hydroxylase Rattus norvegicus 49-51