PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2839099-3 1988 After treatment with cis-DDP, significant platinum binding to plasma components with MW greater than 25 kD was observed; the ratio free-sulfhydryls/protein content decreased during the first two hours, returning to normal values at 24 hours after injection. Platinum 42-50 translocase of inner mitochondrial membrane 8A Homo sapiens 25-28 3652926-2 1987 The aim of the present work was to study the disposition of platinum (Pt) after a higher dose of cis-DDP, to verify the rate of free drug penetration into the tissue and to observe changes in protein binding relative to the dose. Platinum 60-68 translocase of inner mitochondrial membrane 8A Homo sapiens 101-104 3335000-3 1988 DDP-resistant cells that were only 3.3-fold resistant had approximately 50% less accumulated platinum at all concentrations examined. Platinum 93-101 translocase of inner mitochondrial membrane 8A Homo sapiens 0-3 3652926-2 1987 The aim of the present work was to study the disposition of platinum (Pt) after a higher dose of cis-DDP, to verify the rate of free drug penetration into the tissue and to observe changes in protein binding relative to the dose. Platinum 70-72 translocase of inner mitochondrial membrane 8A Homo sapiens 101-104 3951788-1 1986 Cis-dichloro-trans-dihydroxy-bis(isopropylamine)platinum IV (CHIP) is a second-generation cis-platinum (DDP) derivative with an octahedral conformation of the platinum complex, far more water-soluble than DDP. Platinum 48-56 translocase of inner mitochondrial membrane 8A Homo sapiens 104-107 3951788-1 1986 Cis-dichloro-trans-dihydroxy-bis(isopropylamine)platinum IV (CHIP) is a second-generation cis-platinum (DDP) derivative with an octahedral conformation of the platinum complex, far more water-soluble than DDP. Platinum 48-56 translocase of inner mitochondrial membrane 8A Homo sapiens 205-208 6891601-7 1982 The only other products detected were obtained at high levels of cis-DDP and probably represented polymeric forms in which platinum chelates to itself. Platinum 123-131 translocase of inner mitochondrial membrane 8A Homo sapiens 69-72 4039530-5 1985 In patients receiving DDP 100-120 mg/m2, 5/20 with 5-minute plasma platinum concentrations greater than 6 micrograms/ml developed nephrotoxicity; 0/26 with concentrations less than 6 micrograms/ml became nephrotoxic (p less than 0.05). Platinum 67-75 translocase of inner mitochondrial membrane 8A Homo sapiens 22-25 29673791-13 2018 Similarly, Huaier also had a good adjuvant therapeutic effect on enhancing platinum (L-OHP and DDP) and adriamycin (ADM). Platinum 75-83 translocase of inner mitochondrial membrane 8A Homo sapiens 85-98 121143-2 1979 Platinum coordination complexes represent a new class of antineoplastic agents among which only cis-diamminedichloroplatinum(II) (cis-DDP) has undergone extensive clinical trials. Platinum 0-8 translocase of inner mitochondrial membrane 8A Homo sapiens 134-137 25872328-2 2015 MATERIALS AND METHODS: The differential expression of microRNA between COC1 (DDP-sensitive) and platinum-resistant COC1/DDP (DDP-resistant) tumor cell lines was determined using microarray. Platinum 96-104 translocase of inner mitochondrial membrane 8A Homo sapiens 115-123 27877224-1 2016 Purpose: Platinum derivatives, such as cisplatin (DDP), carboplatin and oxaliplatin, are widely used components of modern cancer chemotherapy including esophageal squamous cell cancer (ESCC). Platinum 9-17 translocase of inner mitochondrial membrane 8A Homo sapiens 50-53 27877224-5 2016 To determine whether knockdown the expression of ATP7A could reverse the platinum-resistance of EC109/DDP cells or not, we used RNA interference system to explore the role of ATP7A in platinum resistance. Platinum 73-81 translocase of inner mitochondrial membrane 8A Homo sapiens 102-105 25872328-2 2015 MATERIALS AND METHODS: The differential expression of microRNA between COC1 (DDP-sensitive) and platinum-resistant COC1/DDP (DDP-resistant) tumor cell lines was determined using microarray. Platinum 96-104 translocase of inner mitochondrial membrane 8A Homo sapiens 120-123 8742842-20 1996 DNA REPAIR: In living cells, higher doses of trans-DDP as compared to cis-DDP are required to bind an equal number of Pt atoms per nucleotide [66]. Platinum 118-120 translocase of inner mitochondrial membrane 8A Homo sapiens 51-54 12888918-10 2003 A varying degree of splicing inhibition was observed for the other platinum analogs studied; the inhibitory activity decreased in the following order: ormaplatin > cis-tetraplatin > cis-DDP > iproplatin > carboplatin. Platinum 67-75 translocase of inner mitochondrial membrane 8A Homo sapiens 192-195 12438251-1 2002 Impaired uptake of cisplatin (DDP) consistently accompanies the acquisition of resistance to the platinum drugs. Platinum 97-105 translocase of inner mitochondrial membrane 8A Homo sapiens 30-33 9137537-6 1997 After exposure to CDDP for 4 h, the intracellular platinum content of OCUM-2M cells was significantly higher than that of OCUM-2M/DDP cells (51.9 +/- 1.8 vs 16.4 plus 1.0 ng/mg protein, mean +/- SD, respectively). Platinum 50-58 translocase of inner mitochondrial membrane 8A Homo sapiens 19-22 9275551-8 1996 CONCLUSIONS: The primary factor causing COC1/DDP resistance to DDP is the reduction of intracellular platinum accumulation and DNA ISC formation. Platinum 101-109 translocase of inner mitochondrial membrane 8A Homo sapiens 45-48 9275551-8 1996 CONCLUSIONS: The primary factor causing COC1/DDP resistance to DDP is the reduction of intracellular platinum accumulation and DNA ISC formation. Platinum 101-109 translocase of inner mitochondrial membrane 8A Homo sapiens 63-66 20356529-1 2010 OBJECTIVE: To study the expression of NASP in platinum resistance ovarian cancer cell clones (C0C1/DDP). Platinum 46-54 translocase of inner mitochondrial membrane 8A Homo sapiens 94-102 20356529-5 2010 CONCLUSION: The identification of NASP in C0C1/DDP has laid a foundation for future in-depth researches into the mechanisms of ovarian cancer platinum resistance. Platinum 142-150 translocase of inner mitochondrial membrane 8A Homo sapiens 47-50 8742842-20 1996 DNA REPAIR: In living cells, higher doses of trans-DDP as compared to cis-DDP are required to bind an equal number of Pt atoms per nucleotide [66]. Platinum 118-120 translocase of inner mitochondrial membrane 8A Homo sapiens 74-77 8027742-6 1994 The order of reactivity of the platinum compounds for the GCGC oligonucleotide was 1,1/t,t > 1,0/t > Pt(DIEN) > cis-DDP. Platinum 31-39 translocase of inner mitochondrial membrane 8A Homo sapiens 125-128 8057650-5 1994 The intratumoral concentration of platinum was significantly increased in St-40 treated with the sequence MMC to DDP, in comparison with the sequence DDP to MMC. Platinum 34-42 translocase of inner mitochondrial membrane 8A Homo sapiens 113-116 2302256-7 1990 Measurements of cell-associated platinum indicated that the degree of protection from the inactivating effects of cis-DDP by these aldehydes was related to the degree of reduced platinum accumulation. Platinum 32-40 translocase of inner mitochondrial membrane 8A Homo sapiens 118-121 2302256-7 1990 Measurements of cell-associated platinum indicated that the degree of protection from the inactivating effects of cis-DDP by these aldehydes was related to the degree of reduced platinum accumulation. Platinum 178-186 translocase of inner mitochondrial membrane 8A Homo sapiens 118-121