PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19110234-7	2009	CONCLUSION: Azacitidine enhanced the sensitivity of platinum-resistant ovarian cancer cells to carboplatin associated with caspase-3- and -8-dependent apoptosis pathway and reexpression of DR4.	Platinum	52-60	caspase 3	Homo sapiens	123-140	
18193228-8	2008	PT-262 induced the loss of mitochondrial membrane potential and elevated the caspase-3 activation and apoptosis.	Platinum	0-2	caspase 3	Homo sapiens	77-86	
18719365-5	2008	Further analysis revealed that the sensitization of platinums was associated with platinums-induced suppression of nuclear factor-kappaB (NFkappaB) and subsequent downregulation of X-linked inhibitor of apoptosis protein (XIAP), which rescued caspase-3 from inhibition.	Platinum	52-61	caspase 3	Homo sapiens	243-252	
18719365-5	2008	Further analysis revealed that the sensitization of platinums was associated with platinums-induced suppression of nuclear factor-kappaB (NFkappaB) and subsequent downregulation of X-linked inhibitor of apoptosis protein (XIAP), which rescued caspase-3 from inhibition.	Platinum	82-91	caspase 3	Homo sapiens	243-252	
12499281-7	2002	Concomitant platinum treatment and IR led to poly(ADP-ribose) polymerase cleavage as a sign of caspase-3 activation and apoptosis.	Platinum	12-20	caspase 3	Homo sapiens	95-104	
9380409-3	1997	Here we show that induction of PT is sufficient to activate CPP32-like proteases with DEVDase activity and the associated cleavage of the nuclear DEVDase substrate poly(ADP-ribose) polymerase (PARP).	Platinum	31-33	caspase 3	Homo sapiens	60-65	
34794242-0	2021	The endocytic pathway of Pt nanoclusters and their induced apoptosis of A549 and A549/Cis cells through c-Myc/p53 and Bcl-2/caspase-3 signaling pathways.	Platinum	25-27	caspase 3	Homo sapiens	124-133	
24169734-10	2014	The activity of the apoptosis-promoting protein caspase 3/7 was determined; results proved that these novel platinum compounds, under the chosen experimental conditions, preferentially induce apoptosis over necrosis.	Platinum	108-116	caspase 3	Homo sapiens	48-57	
33689300-4	2021	The polymer encapsulated a platinum intercalator (56MESS, (5,6-dimethyl-1,10-phenanthroline) (1S,2S-diaminocyclohexane) platinum(II)) and was conjugated with both a cell-targeting RGD peptide and a caspase-3 cleavable peptide probe to form nanoparticles for simultaneous NIR-II and apoptosis imaging.	Platinum	27-35	caspase 3	Homo sapiens	198-207	
32309901-0	2020	Platinum nanoparticles induced genotoxicity and apoptotic activity in human normal and cancer hepatic cells via oxidative stress-mediated Bax/Bcl-2 and caspase-3 expression.	Platinum	0-8	caspase 3	Homo sapiens	152-161	
32900227-9	2021	In addition, overexpression of pro-apoptotic (Bax) protein, caspase-3 activity and histone release were increased after treatment of both cell lines with different PT concentrations.	Platinum	164-166	caspase 3	Homo sapiens	60-69	
30826588-5	2019	The coumarin platinum(IV) complex could effectively induce apoptosis of SKOV-3 cells through up-regulating the expression of caspase3 and caspase9.	Platinum	13-21	caspase 3	Homo sapiens	125-133	
22568453-0	2012	Association of CASP3 polymorphism with hematologic toxicity in patients with advanced non-small-cell lung carcinoma treated with platinum-based chemotherapy.	Platinum	129-137	caspase 3	Homo sapiens	15-20	
22039334-8	2011	Importantly, both cerium oxide and platinum nanoparticles reduce oxidant-mediated apoptosis in target cells as judged by the activation of caspase 3.	Platinum	35-43	caspase 3	Homo sapiens	139-148	
20517311-6	2010	The combination of YM155 and platinum compounds also induced synergistic increases both in the number of apoptotic cells and in the activity of caspase-3.	Platinum	29-37	caspase 3	Homo sapiens	144-153