PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27397648-2	2016	Of these mutations, the homoplasmic m.1555A>G or m.1494C>T mutation in the highly conserved A-site of MT-RNR1 gene has been found to be associated with both aminoglycoside-induced and non-syndromic hearing loss in many families worldwide.	Aminoglycosides	163-177	mitochondrially encoded 12S RNA	Homo sapiens	108-115	
32630724-1	2020	Specific genetic variants in the mitochondrially encoded 12S ribosomal RNA gene (MT-RNR1) cause aminoglycoside-induced irreversible hearing loss.	Aminoglycosides	96-110	mitochondrially encoded 12S RNA	Homo sapiens	81-88	
34032273-0	2022	Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of aminoglycosides based on MT-RNR1 genotype.	Aminoglycosides	84-99	mitochondrially encoded 12S RNA	Homo sapiens	109-116	
34032273-3	2022	Some MT-RNR1 variants (i.e., m.1095T>C; m.1494C>T; m.1555A>G) more closely resemble the bacterial 16s rRNA subunit and result in increased risk of aminoglycoside-induced hearing loss.	Aminoglycosides	147-161	mitochondrially encoded 12S RNA	Homo sapiens	5-12	
34032273-4	2022	Use of aminoglycosides should be avoided in individuals with an MT-RNR1 variant associated with an increased risk of aminoglycoside-induced hearing loss unless the high risk of permanent hearing loss is outweighed by the severity of infection and safe or effective alternative therapies are not available.	Aminoglycosides	7-22	mitochondrially encoded 12S RNA	Homo sapiens	64-71	
34032273-4	2022	Use of aminoglycosides should be avoided in individuals with an MT-RNR1 variant associated with an increased risk of aminoglycoside-induced hearing loss unless the high risk of permanent hearing loss is outweighed by the severity of infection and safe or effective alternative therapies are not available.	Aminoglycosides	7-21	mitochondrially encoded 12S RNA	Homo sapiens	64-71	
34032273-5	2022	We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of aminoglycosides based on MT-RNR1 genotype (updates at https://cpicpgx.org/guidelines/ and www.pharmgkb.org).	Aminoglycosides	125-140	mitochondrially encoded 12S RNA	Homo sapiens	150-157	
30523288-3	2019	MT-RNR1 gene encoding the mitochondrial ribosomal 12S subunit is a hot spot for aminoglycoside-induced hearing loss mutations, however, a variability in the nature and frequency of genetic changes in different populations exists.	Aminoglycosides	80-94	mitochondrially encoded 12S RNA	Homo sapiens	0-7	
30523288-7	2019	The presence of several aminoglycoside ototoxicity-related MT-RNR1 gene mutations in Baltic-speaking Latvian population indicates the necessity to include ototoxicity-related mutation analysis in the future studies in order to determine the feasibility of DNA screening for patients before administration of aminoglycoside therapy.	Aminoglycosides	24-38	mitochondrially encoded 12S RNA	Homo sapiens	59-66	
30523288-7	2019	The presence of several aminoglycoside ototoxicity-related MT-RNR1 gene mutations in Baltic-speaking Latvian population indicates the necessity to include ototoxicity-related mutation analysis in the future studies in order to determine the feasibility of DNA screening for patients before administration of aminoglycoside therapy.	Aminoglycosides	308-322	mitochondrially encoded 12S RNA	Homo sapiens	59-66	
23969527-4	2013	A novel sporadic mutation in 12S rRNA (MT-RNR1), not previously reported in the literature, was found in a case of possible aminoglycoside-induced progressive deafness.	Aminoglycosides	124-138	mitochondrially encoded 12S RNA	Homo sapiens	39-46	
26168747-1	2015	BACKGROUND: This was a meta-analysis and systematic review to determine the global prevalence of the mitochondrially encoded 12S RNA (MT-RNR1) genetic mutation in order to assess the need for neonatal screening prior to aminoglycoside therapy.	Aminoglycosides	220-234	mitochondrially encoded 12S RNA	Homo sapiens	134-141	
20111055-2	2010	This study analyzed 373 patients with suspected hereditary HL using an extensive and rapid suspension-array screening system for 29 major mtDNA mutations, including the m.1555A>G homoplasmic mutation in the MT-RNR1 gene, which causes non-syndromic sensorineural HL and aminoglycoside-induced HL, and the m.3243A>G heteroplasmic mutation in the MT-TL1 gene.	Aminoglycosides	272-286	mitochondrially encoded 12S RNA	Homo sapiens	210-217