PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
567762-6	1978	Measurement of brain, serum, and CSF levels of phenytoin in six patients showed that brain levels were 4 to 10 times higher than free drug as measured in the CSF.	Phenytoin	47-56	colony stimulating factor 2	Homo sapiens	33-36	
3986076-0	1985	Protein binding and CSF penetration of phenytoin following acute oral dosing in man.	Phenytoin	39-48	colony stimulating factor 2	Homo sapiens	20-23	
3986076-5	1985	DPH protein binding at that time varied two-fold (9.2-18.5%) and free drug levels (1.7 +/- 0.6 mg l-1) correlated with CSF (r = 0.83, P less than 0.001) and total (r = 0.89, P less than 0.001) plasma DPH concentrations.	Phenytoin	0-3	colony stimulating factor 2	Homo sapiens	119-122	
3986076-6	1985	There were significant negative correlations between patient weight (n = 17) and total (r = 0.57, P less than 0.05) and CSF (r = -0.55, P less than 0.05) DPH concentrations at myelography.	Phenytoin	154-157	colony stimulating factor 2	Homo sapiens	120-123	
3986076-9	1985	A simple regime involving two doses of DPH would provide acceptable plasma CSF concentrations as a basis for controlled studies in seizure prophylaxis following neuroradiological investigations involving intrathecal contrast.	Phenytoin	39-42	colony stimulating factor 2	Homo sapiens	75-78	
6413048-0	1983	Kinetics of CSF phenytoin in children.	Phenytoin	16-25	colony stimulating factor 2	Homo sapiens	12-15	
6413048-6	1983	The ratio of CSF/serum phenytoin concentrations was 0.16 +/- 0.08, with gradual increase over the first 8 hours as the serum phenytoin concentration decreased.	Phenytoin	125-134	colony stimulating factor 2	Homo sapiens	13-16	
6413048-7	1983	There was good correlation between therapeutic outcome and CSF phenytoin levels higher than 2 mcg/ml.	Phenytoin	63-72	colony stimulating factor 2	Homo sapiens	59-62	
6413048-8	1983	In one patient the coma state secondary to phenytoin intoxication was associated with high CSF concentration (6 mcg/ml).	Phenytoin	43-52	colony stimulating factor 2	Homo sapiens	91-94	
567762-6	1978	Measurement of brain, serum, and CSF levels of phenytoin in six patients showed that brain levels were 4 to 10 times higher than free drug as measured in the CSF.	Phenytoin	47-56	colony stimulating factor 2	Homo sapiens	158-161	
991879-0	1976	Reduced CSF IgG in patients treated with phenytoin (diphenylhydantoin).	Phenytoin	41-50	colony stimulating factor 2	Homo sapiens	8-11	
991879-0	1976	Reduced CSF IgG in patients treated with phenytoin (diphenylhydantoin).	Phenytoin	52-69	colony stimulating factor 2	Homo sapiens	8-11	
991879-1	1976	In the CSF"s from 13 out of 30 phenytoin-treated patients the IgG concentrations were lower than the lowest amont 20 controls, while only 3 out of 37 patients with brain lesions without epilepsy had so low IgG value.	Phenytoin	31-40	colony stimulating factor 2	Homo sapiens	7-10	
1188268-0	1975	Relationships among dose, serum and CSF levels and urinary output in fenobarbital and fenitoin treatment of epileptics.	Phenytoin	86-94	colony stimulating factor 2	Homo sapiens	36-39	
1233256-4	1975	Assuming that CSF is an ultrafiltrate of plasma, the percentage of phenytoin, phenobarbitone and primidone which was unbound in plasma was 10-14%, 43% and 81% respectively.	Phenytoin	67-76	colony stimulating factor 2	Homo sapiens	14-17	
5535043-0	1970	CSF and serum folic acid and protein changes with diphenylhydantoin treatment: laboratory and clinical correlations.	Phenytoin	50-67	colony stimulating factor 2	Homo sapiens	0-3	
8315450-0	1993	Severe phenytoin-induced bone marrow depression and agranulocytosis treated with human recombinant granulocyte-macrophage colony-stimulating factor.	Phenytoin	7-16	colony stimulating factor 2	Homo sapiens	99-147