PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24478822-1 2012 PROBLEM STATEMENT: Diphenylhydantoin (phenytoin) is an antiepileptic drug that generates hyperplasia in some tissue by stimulating Epidermal Growth Factor (EGFR) and Platelet-Derived Growth Factor beta (PDGFR-beta) receptors and by increasing serum levels of basic fibroblast growth factor (bFGF, FGF2 or FGF-beta). Phenytoin 19-36 epidermal growth factor Homo sapiens 131-154 9385775-0 1997 Fibroblasts derived from tissue explants of dilantin-induced gingival hyperplasia and idiopathic gingival fibromatosis show distinct disparity in proliferative responsiveness to epidermal growth factor. Phenytoin 44-52 epidermal growth factor Homo sapiens 178-201 9379324-12 1997 EGF and IL-1 present in inflammatory exudate may have implications on phenytoin-induced overgrowth via the steroid metabolic pathway. Phenytoin 70-79 epidermal growth factor Homo sapiens 0-3 2139117-4 1990 The steady-state level of EGF-r mRNA increased significantly (p less than 0.001) in the cultured fibroblasts derived from the non-responder but decreased (p less than 0.05) in the responder patient following PHT therapy. Phenytoin 208-211 epidermal growth factor Homo sapiens 26-29 2139117-6 1990 The study indicates that PHT medication results in a down-regulation of EGF receptor metabolism in fibroblasts derived from a responder patient, whereas in the non-responder patient EGF receptor metabolism is up-regulated. Phenytoin 25-28 epidermal growth factor Homo sapiens 72-75 24478822-1 2012 PROBLEM STATEMENT: Diphenylhydantoin (phenytoin) is an antiepileptic drug that generates hyperplasia in some tissue by stimulating Epidermal Growth Factor (EGFR) and Platelet-Derived Growth Factor beta (PDGFR-beta) receptors and by increasing serum levels of basic fibroblast growth factor (bFGF, FGF2 or FGF-beta). Phenytoin 19-36 epidermal growth factor Homo sapiens 156-160