PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31056982-5	2019	Additionally, osthole treatment reduced the expression of microglia and glial scar, lowered the level of the proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), and blocked the activation of nuclear factor kappa B (NF-kappaB).	osthol	14-21	interleukin 6	Homo sapiens	135-153	
30380512-4	2018	Osthole repressed ox-LDL-induced release of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 in HUVECs.	osthol	0-7	interleukin 6	Homo sapiens	113-117	
29743895-7	2018	50 and 100 muM osthole also blocked the generation of IL-6 and TNF-alpha in IL-1beta-stimulated SW982 cells.	osthol	15-22	interleukin 6	Homo sapiens	54-58	
25876063-5	2015	Osthole was able to suppress the levels of proinflammatory cytokines interleukin (IL)-1beta and IL-6, as well as chemokines monocyte chemoattractant protein-1 and IL-8.	osthol	0-7	interleukin 6	Homo sapiens	96-100	
25689951-6	2015	RESULTS: Following treatment of adipocytes with osthole 0.1-1.6 muM, the TNF-alpha and IL-6 levels in cultured supernatants were decreased, and the NF-kappaB p65 protein expression in adipocytes was also decreased, while the PPARalpha/gamma protein expressions were increased.	osthol	48-55	interleukin 6	Homo sapiens	87-91	
25689951-7	2015	After pretreatment of adipocytes with specific inhibitor(s) of PPARalpha and /or PPARgamma, the inhibitory effects of osthole on TNF-alpha and IL-6 were decreased or almost cancelled, and the effects on NF-kappaB p65 protein expression also exhibited similar variations.	osthol	118-125	interleukin 6	Homo sapiens	143-147	
25689951-8	2015	CONCLUSION: Osthole could inhibit the TNF-alpha and IL-6 production in LPS-stimulated adipocytes, and its mechanism might be related to reduction of NF-kappaB expression via activation of PPARalpha/gamma.	osthol	12-19	interleukin 6	Homo sapiens	52-56