PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31301565-0	2019	Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.	Thiophenes	22-31	AKT serine/threonine kinase 1	Homo sapiens	76-79	
31301565-1	2019	A series of pyrazole-thiophene derivatives exhibiting good Akt inhibitory activities were obtained on the basis of conformational restriction strategy, leading to the discovery of compound 1d and 1o which showed excellent in vitro antitumor effect against a variety of hematologic cancer cells and their potential of inducing apoptosis, blocking the cell cycles at S phase and significantly inhibiting the phosphorylation of downstream biomarkers of Akt kinase of cancer cells.	Thiophenes	21-30	AKT serine/threonine kinase 1	Homo sapiens	59-62