PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32801081-0	2020	Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives.	Thiophenes	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-55	
14751313-0	2004	Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.	Thiophenes	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19	
12620660-1	2003	Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole, thiophene or isoxazole ring, were synthesized, in order to verify the influence of the different nature of the central core on the COX inhibitory properties of these kinds of molecules.	Thiophenes	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100	
33748613-1	2021	A selective triazole-based COX-2 inhibitor, 4-(4-chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole, C19H13ClFN3S2, has been synthesized, and its crystal structure was determined at 150 K. Single-crystal X-ray diffraction analysis revealed that the thiophene ring was disordered over two orientations.	Thiophenes	277-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32	
25573411-1	2015	One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to alpha,beta-unsaturated carbonyl compounds.	Thiophenes	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115	
30807897-9	2019	Therefore, the thiophene analog 3 and the thienopyrimidine derivatives 10 and 11 are promising anti-inflammatory candidates that exert moderate selective COX-2 inhibition with acceptable physicochemical properties.	Thiophenes	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159