PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2912581-8	1989	Aflatoxin-B1 was found to be 2-3 times more mutagenic to cells bearing the transfected cytochrome P1-450 activity as compared with control cells.	Aflatoxin B1	0-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-104	
24168324-9	2014	Among CYP1A1, CYP1B1 and CYP3A4 only CYP1A1 responded to low and moderate levels of AFB1.	Aflatoxin B1	84-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-12	
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	Aflatoxin B1	66-78	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	156-163	
24168324-9	2014	Among CYP1A1, CYP1B1 and CYP3A4 only CYP1A1 responded to low and moderate levels of AFB1.	Aflatoxin B1	84-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	37-43	
23402939-1	2013	Effects of 96 h aflatoxin B1 (AFB1) exposure at concentrations from 0.2 muM to 6 muM on the mRNA and protein expression levels of the following transporters ABCB1/B4, ABCC1, ABCC2, ABCG2, OAT4 and the mRNA expression of steroid-metabolizing enzymes CYP1A1, CYP19A1, HSD3B1 and HSD17B1, and conjugating enzyme family UGT1A were evaluated in trophoblastic JEG-3 cells.	Aflatoxin B1	16-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	249-255	
23402939-1	2013	Effects of 96 h aflatoxin B1 (AFB1) exposure at concentrations from 0.2 muM to 6 muM on the mRNA and protein expression levels of the following transporters ABCB1/B4, ABCC1, ABCC2, ABCG2, OAT4 and the mRNA expression of steroid-metabolizing enzymes CYP1A1, CYP19A1, HSD3B1 and HSD17B1, and conjugating enzyme family UGT1A were evaluated in trophoblastic JEG-3 cells.	Aflatoxin B1	30-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	249-255	
21994236-5	2012	Aflatoxin B1 was found also to induce an overexpression of CYP1A1 and CYP1A2 genes accompanied by an increase in AhR mRNA expression.	Aflatoxin B1	0-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65	
8200084-6	1994	Using the microsomes, it was demonstrated that aflatoxin B1 was activated to a mutagen not only by CYP1A2 but also by CYP1A1.	Aflatoxin B1	47-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124	
8044792-3	1994	CYP1A1 metabolizes AFB1 to form an epoxide intermediate which can react with DNA.	Aflatoxin B1	19-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6	
11752683-3	2002	Coexpression of mEH with CYP1A1 or CYP1A2 resulted in significant decreases in measurements of AFB genotoxicity.	Aflatoxin B1	95-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	25-31	
11752683-6	2002	The mutagenicity of AFB in the Ames assay was also decreased by approximately 50% when AFB was incubated with microsomes containing CYP1A1 or CYP1A2 and mEH versus CYP1A1 or CYP1A2 alone.	Aflatoxin B1	20-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138	
11752683-6	2002	The mutagenicity of AFB in the Ames assay was also decreased by approximately 50% when AFB was incubated with microsomes containing CYP1A1 or CYP1A2 and mEH versus CYP1A1 or CYP1A2 alone.	Aflatoxin B1	20-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	164-170	
7923587-6	1994	CYP1A2 was more active than CYP1A1 for acetanilide hydroxylation and activation of aflatoxin B1 (AFB1).	Aflatoxin B1	83-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34	
7923587-6	1994	CYP1A2 was more active than CYP1A1 for acetanilide hydroxylation and activation of aflatoxin B1 (AFB1).	Aflatoxin B1	97-101	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34