PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6287253-3 1982 The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay. Aflatoxin B1 334-346 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 109-137 24168324-9 2014 Among CYP1A1, CYP1B1 and CYP3A4 only CYP1A1 responded to low and moderate levels of AFB1. Aflatoxin B1 84-88 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 14-20 9106248-9 1997 In order to begin to characterize the promutagen activating ability of CYP1B1, the mutagenicity of selected chemicals was examined in h1B1/OR cells; there was increased sensitivity (CYP1B1-expressing relative to control cells) to the mutagenicity of benzo(a)pyrene, cyclopenta(c,d)pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and aflatoxin B1 (AFB). Aflatoxin B1 340-352 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-77 9106248-9 1997 In order to begin to characterize the promutagen activating ability of CYP1B1, the mutagenicity of selected chemicals was examined in h1B1/OR cells; there was increased sensitivity (CYP1B1-expressing relative to control cells) to the mutagenicity of benzo(a)pyrene, cyclopenta(c,d)pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and aflatoxin B1 (AFB). Aflatoxin B1 354-357 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-77