PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12958799-1 2003 BACKGROUND: The influence of low doses of aflatoxin B1(AFB1) and partial hepatectomy (PH) on glutathione-S-transferase (GST) activity was studied in the plasma and liver of the rat. Aflatoxin B1 42-54 hematopoietic prostaglandin D synthase Rattus norvegicus 120-123 12958799-0 2003 Aflatoxin B1-induced changes of glutathione-S-transferase activity in the plasma and liver of the rat. Aflatoxin B1 0-12 hematopoietic prostaglandin D synthase Rattus norvegicus 32-57 12958799-1 2003 BACKGROUND: The influence of low doses of aflatoxin B1(AFB1) and partial hepatectomy (PH) on glutathione-S-transferase (GST) activity was studied in the plasma and liver of the rat. Aflatoxin B1 42-54 hematopoietic prostaglandin D synthase Rattus norvegicus 93-118 12958799-8 2003 CONCLUSION: The administration of both single and multiple doses of AFB1 led to long term increase of GST activity in the rat plasma and liver, and partial hepatectomy had no significant effect on this phenomenon. Aflatoxin B1 68-72 hematopoietic prostaglandin D synthase Rattus norvegicus 102-105 9934864-0 1999 Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats. Aflatoxin B1 114-126 hematopoietic prostaglandin D synthase Rattus norvegicus 15-40 12076648-3 2002 Cytosolic GST activity toward AFB1-epoxide was highest in mastomys liver, and higher in the hamster and mouse livers than in the rat liver, correlating well with the differences of the sensitivity of these species to the toxicity of AFB1. Aflatoxin B1 30-34 hematopoietic prostaglandin D synthase Rattus norvegicus 10-13 12076648-5 2002 These results demonstrate the importance of the GST mediated AFB1-epoxide conjugation with glutathione in determining the differing sensitivities of these species to AFB1 toxicity. Aflatoxin B1 61-65 hematopoietic prostaglandin D synthase Rattus norvegicus 48-51 10797475-0 2000 Effects of intermittent exposures of aflatoxin B(1) on hepatic and testicular glutathione S-transferase in rats. Aflatoxin B1 37-48 hematopoietic prostaglandin D synthase Rattus norvegicus 78-103 10797475-1 2000 Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). Aflatoxin B1 104-115 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 10797475-1 2000 Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). Aflatoxin B1 104-115 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 10797475-2 2000 This study evaluated the effects of intermittent exposures to AFB(1) on hepatic and testicular GST in rats. Aflatoxin B1 62-68 hematopoietic prostaglandin D synthase Rattus norvegicus 95-98 10797475-6 2000 Intermittent exposures to AFB(1) at concentrations of 0.04-1.6 ppm significantly increased the GST activities. Aflatoxin B1 26-32 hematopoietic prostaglandin D synthase Rattus norvegicus 95-98 10398377-0 1999 Temporal patterns of DNA adduct formation and glutathione S-transferase activity in the testes of rats fed aflatoxin B1: a comparison with patterns in the liver. Aflatoxin B1 107-119 hematopoietic prostaglandin D synthase Rattus norvegicus 46-71 7889530-6 1995 It is concluded that the protective effect of DDB against AFB1-induced damage might be mediated by the induced glutathione S-transferase activity and not from the accelerated hepatic cytochrome P450 detoxification pathway of AFB1 which was previously believed. Aflatoxin B1 58-62 hematopoietic prostaglandin D synthase Rattus norvegicus 111-136 9756133-7 1998 Administration of AFB1 resulted in significant increases in serum alanine aminotransferase (ALT) and glutathione S-transferase (GST) levels and a significant decrease in aniline hydroxylase activity in liver microsomes. Aflatoxin B1 18-22 hematopoietic prostaglandin D synthase Rattus norvegicus 101-126 9756133-7 1998 Administration of AFB1 resulted in significant increases in serum alanine aminotransferase (ALT) and glutathione S-transferase (GST) levels and a significant decrease in aniline hydroxylase activity in liver microsomes. Aflatoxin B1 18-22 hematopoietic prostaglandin D synthase Rattus norvegicus 128-131 9679543-3 1998 The glutathione S-transferase (GST) isoenzymes in rat liver that contribute to ethoxyquin-induced chemoprotection against AFB1 have been identified by protein purification. Aflatoxin B1 122-126 hematopoietic prostaglandin D synthase Rattus norvegicus 4-29 9679543-3 1998 The glutathione S-transferase (GST) isoenzymes in rat liver that contribute to ethoxyquin-induced chemoprotection against AFB1 have been identified by protein purification. Aflatoxin B1 122-126 hematopoietic prostaglandin D synthase Rattus norvegicus 31-34 2104996-0 1990 Effect of aflatoxin B1 treatment in vivo on the in vitro activity of hepatic and extrahepatic glutathione S-transferase. Aflatoxin B1 10-22 hematopoietic prostaglandin D synthase Rattus norvegicus 94-119 8330366-0 1993 Modulation of aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci by pretreatment of rats with phenobarbital and buthionine sulfoximine. Aflatoxin B1 14-26 hematopoietic prostaglandin D synthase Rattus norvegicus 35-60 1451106-0 1992 Species and sex differences of aflatoxin B1-induced glutathione S-transferase placental form in single hepatocytes. Aflatoxin B1 31-43 hematopoietic prostaglandin D synthase Rattus norvegicus 52-77 8198522-8 1994 Administration of the antioxidants EQ, BHA or BHT, as well as PB, led to a marked increase in levels of the GST Yc2 subunit in rat liver, and this increase coincided with a substantial rise in the GST activity towards AFB1-8,9-epoxide; neither AFB1, 3-MC nor clofibrate caused induction of Yc2 or any of the GST subunits examined. Aflatoxin B1 244-249 hematopoietic prostaglandin D synthase Rattus norvegicus 108-111 8198522-8 1994 Administration of the antioxidants EQ, BHA or BHT, as well as PB, led to a marked increase in levels of the GST Yc2 subunit in rat liver, and this increase coincided with a substantial rise in the GST activity towards AFB1-8,9-epoxide; neither AFB1, 3-MC nor clofibrate caused induction of Yc2 or any of the GST subunits examined. Aflatoxin B1 244-249 hematopoietic prostaglandin D synthase Rattus norvegicus 197-200 2173169-10 1990 These studies demonstrate that the resistance of mouse liver to AFB1 can be explained primarily by a single constitutive GST isoenzyme (YaYa or 4-4) with a relatively high activity toward DNA-binding metabolites of AFB1. Aflatoxin B1 64-68 hematopoietic prostaglandin D synthase Rattus norvegicus 121-124 2173169-10 1990 These studies demonstrate that the resistance of mouse liver to AFB1 can be explained primarily by a single constitutive GST isoenzyme (YaYa or 4-4) with a relatively high activity toward DNA-binding metabolites of AFB1. Aflatoxin B1 215-219 hematopoietic prostaglandin D synthase Rattus norvegicus 121-124 2173169-11 1990 GST isoenzymes with such high specific DNA protective activity against AFB1 metabolites were not evident in human, rat, or rainbow trout liver or in PCB-induced or neoplastic rat liver preparations. Aflatoxin B1 71-75 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 2112061-0 1990 Glutathione S-transferase localization in aflatoxin B1-treated rat livers. Aflatoxin B1 42-54 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 2104996-1 1990 The effect of aflatoxin B1 (AFB1) on the glutathione S-transferase activity (GST) and on non-protein thiol levels of different tissues was studied in adult male Wistar rats. Aflatoxin B1 28-32 hematopoietic prostaglandin D synthase Rattus norvegicus 41-66 7459255-5 1980 dose (6 mg/kg body wt) of aflatoxin B1 on the specific activities of microsomal demethylases, aryl hydrocarbon hydroxylase (AHH), glutathione S-transferase and glutathione peroxidase in rat liver, kidney, lung, brain and adrenals. Aflatoxin B1 26-38 hematopoietic prostaglandin D synthase Rattus norvegicus 130-155 2508094-2 1989 Induction of hepatic enzymes, such as glutathione S-transferase, UDP-glucuronyltransferase, and epoxide hydrolase, has been shown to be responsible for the reduction of AFB1 cytotoxic and carcinogenic effects. Aflatoxin B1 169-173 hematopoietic prostaglandin D synthase Rattus norvegicus 38-63 3131540-3 1988 Significantly low activities of UDP-glucuronyltransferase and glutathione S-transferase were observed in food-restricted animals fed on aflatoxin B1. Aflatoxin B1 136-148 hematopoietic prostaglandin D synthase Rattus norvegicus 62-87 3131540-5 1988 UDP-Glucuronyltransferase and glutathione S-transferase in undernutrition seem to respond differently to aflatoxin B1 and N-acetylaminofluorene. Aflatoxin B1 105-117 hematopoietic prostaglandin D synthase Rattus norvegicus 30-55 6411367-0 1983 The requirement for glutathione S-transferase in the conjugation of activated aflatoxin B1 during aflatoxin hepatocarcinogenesis in the rat. Aflatoxin B1 78-90 hematopoietic prostaglandin D synthase Rattus norvegicus 20-45 6411367-4 1983 Studies using CM-cellulose columns showed the fractions containing glutathione S-transferase B activity were the most effective in catalysing the formation of the AFB1-GSH conjugate. Aflatoxin B1 163-167 hematopoietic prostaglandin D synthase Rattus norvegicus 67-92 26412696-6 2015 Moreover, we have observed that curcumin also reduced glutathione S-transferase placental form positive single cells and foci caused by AFB1 treatment. Aflatoxin B1 136-140 hematopoietic prostaglandin D synthase Rattus norvegicus 54-79 15964045-2 2005 The GST activity was determined by incubating the liver cytosol with glutathione (GSH) and AFB1 in the presence of the hamster liver microsomes to metabolize AFB1 to AFB1-8, 9-epoxide. Aflatoxin B1 91-95 hematopoietic prostaglandin D synthase Rattus norvegicus 4-7